Tuberculosis is still an important health problem in our country as its prevalence has increased in recent years. Isoniazid is one of the most commonly used antituberculous drugs because it is cheap and efficacious. When administered at high doses; it can cause convulsions, metabolic acidosis, lactic acidosis, rhabdomyolisis, coma, and even death. The basis of therapy consists of parenteral pyridoxine administration in a dose equivalent to that of the ingested isoniazid. Here we reported three cases of acute isoniazid intoxication presenting with convulsions and aimed to discuss the clinical signs, pathophysiology, and treatment of isoniazid intoxication. Turkish Baslik: Izoniazid Zehirlenmesi: Uc Olgunun Sunumu Anahtar Kelimeler: Izonazid zehirlenmesi; konvulsiyon; cocuklar; B6 vitamin tedavisi Son yillarda gorulme sikligi yeniden artan tuberkuloz, ulkemiz icin halen onemli bir toplum sagligi sorunudur. Izoniazid, ucuz ve etkin olmasi nedeniyle en sik kullanilan antituberkuloz ilaclardan biridir. Yuksek dozlarda alindiginda konvulsiyon, metabolik asidoz, laktik asidoz, rabdomiyoliz, koma ve hatta olumle sonuclanabilir. Temel tedavi alinan izoniazide es dozda verilen parenteral piridoksin uygulamasidir. Burada konvulsiyon gecirdigi icin getirilen uc olgu sunulmus olup, izoniazid zehirlenmesinin klinik ve metabolik bulgulari ile tedavi yaklasiminin tartisilmasi amaclanmistir.
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