Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer

[1]  S. Yuspa,et al.  Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. , 2015, Biochimica et biophysica acta.

[2]  Robert C. G. Martin,et al.  High-risk population in sporadic pancreatic adenocarcinoma: guidelines for screening. , 2015, The Journal of surgical research.

[3]  John M. Asara,et al.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function , 2014, Nature.

[4]  Qiulan Chen,et al.  Circulating microRNA-182 in plasma and its potential diagnostic and prognostic value for pancreatic cancer , 2014, Medical Oncology.

[5]  Jinjian Yang,et al.  Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through the MAPK/ERK pathway. , 2014, Cancer biotherapy & radiopharmaceuticals.

[6]  Jian Li,et al.  Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer. , 2014, Hepatobiliary & pancreatic diseases international : HBPD INT.

[7]  Simon C Watkins,et al.  Relocation of CLIC1 Promotes Tumor Cell Invasion and Colonization of Fibrin , 2014, Molecular Cancer Research.

[8]  W. Lu,et al.  Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway , 2014, Nature Genetics.

[9]  H. Weng,et al.  CLIC1 overexpression is associated with poor prognosis in gallbladder cancer , 2014, Tumor Biology.

[10]  Chen Huang,et al.  SMAD4 and its role in pancreatic cancer , 2014, Tumor Biology.

[11]  Amy Y. M. Au,et al.  p53 status determines the role of autophagy in pancreatic tumour development , 2013, Nature.

[12]  S. Zhang,et al.  Chloride intracellular channel 1 is overexpression in hepatic tumor and correlates with a poor prognosis , 2013, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[13]  Rui Zhang,et al.  Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion , 2013, Medical Oncology.

[14]  Lincoln D. Stein,et al.  Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes , 2012, Nature.

[15]  Zhen Wang,et al.  Function of chloride intracellular channel 1 in gastric cancer cells. , 2012, World journal of gastroenterology.

[16]  G. Gao,et al.  Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas , 2012, Journal of experimental & clinical cancer research : CR.

[17]  G. Kristiansen,et al.  The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma , 2012, Nature.

[18]  Jian-hua Xu,et al.  Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD , 2012, Molecular and Cellular Biochemistry.

[19]  Jianxing He,et al.  The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma , 2011, Tumor Biology.

[20]  S. Skaper Ion channels on microglia: therapeutic targets for neuroprotection. , 2011, CNS & neurological disorders drug targets.

[21]  J. Kitajewski,et al.  Chloride intracellular channel 1 functions in endothelial cell growth and migration , 2010, Journal of angiogenesis research.

[22]  M. Duchen,et al.  Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress , 2010, FEBS letters.

[23]  L. Mao,et al.  Antibodies targeting hepatoma-derived growth factor as a novel strategy in treating lung cancer , 2009, Molecular Cancer Therapeutics.

[24]  D. Toncheva,et al.  Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer. , 2008, Clinical biochemistry.

[25]  Harpreet Singh,et al.  Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore. , 2006, Biophysical journal.

[26]  W. D. Fairlie,et al.  The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition* , 2004, Journal of Biological Chemistry.

[27]  Rork Kuick,et al.  Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. , 2003, Cancer research.

[28]  J. Edwards,et al.  CLIC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel. , 2002, American journal of physiology. Cell physiology.