Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.
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K. Jacobson | T. K. Harden | P. Kováč | A. Ivanov | Arijit Das | B. Joshi | A. Melman | K. Kirk | Yixing Zhou | R. Carter | H. Ko | I. Fricks | Jan Hajduch | T. Harden | Ingrid P. Fricks
[1] K. Jacobson,et al. Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives. , 2009, Bioorganic & medicinal chemistry letters.
[2] Dov Barak,et al. Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure. , 2009, Journal of medicinal chemistry.
[3] R. Stevens,et al. The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist , 2008, Science.
[4] K. Jacobson,et al. Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands. , 2008, Journal of Organic Chemistry.
[5] H. Koerber,et al. Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2 , 2008, PAIN.
[6] K. Jacobson,et al. Development of selective agonists and antagonists of P2Y receptors , 2008, Purinergic Signalling.
[7] K. Jacobson,et al. Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. , 2008, Bioorganic & medicinal chemistry letters.
[8] K. Jacobson,et al. UDP Is a Competitive Antagonist at the Human P2Y14 Receptor , 2008, Journal of Pharmacology and Experimental Therapeutics.
[9] S. Endres,et al. P2Y receptor signaling regulates phenotype and IFN-alpha secretion of human plasmacytoid dendritic cells. , 2008, Blood.
[10] K. Jacobson,et al. Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands , 2008, Nucleosides, nucleotides & nucleic acids.
[11] G. Dubyak,et al. The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation , 2008, Purinergic Signalling Purinergic Signalling.
[12] R. Fröhlich,et al. A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT). , 2008, Carbohydrate research.
[13] F. Di Virgilio,et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells , 2007, Nature Medicine.
[14] J. Vignon,et al. Expression of purinergic P2Y receptor subtypes by INS-1 insulinoma beta-cells: a molecular and binding characterization. , 2007, European journal of pharmacology.
[15] K. Jacobson,et al. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. , 2007, Journal of medicinal chemistry.
[16] Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety. , 2007, Bioorganic & medicinal chemistry letters.
[17] Olle Melander,et al. Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. , 2006, European heart journal.
[18] Stefano Costanzi,et al. Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling , 2006, J. Comput. Aided Mol. Des..
[19] T Kendall Harden,et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. , 2006, Journal of medicinal chemistry.
[20] Eric A. Barnard,et al. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy , 2006, Pharmacological Reviews.
[21] I. Kügelgen. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes , 2006 .
[22] R. Storer,et al. A short and novel synthesis of carbocyclic nucleosides and 4'-epi-carbocyclic nucleosides from 2-cyclopenten-1-ones , 2006 .
[23] C. Gachet. Regulation of platelet functions by P2 receptors. , 2006, Annual review of pharmacology and toxicology.
[24] M. A. Ivanov,et al. New N 4 -Hydroxycytidine Derivatives: Synthesis and Antiviral Activity , 2006 .
[25] F. Di Virgilio,et al. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. , 2005, American journal of respiratory cell and molecular biology.
[26] Marcus Elstner,et al. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. , 2004, Journal of molecular biology.
[27] Seiko F. Okada,et al. Nucleotide Release Provides a Mechanism for Airway Surface Liquid Homeostasis* , 2004, Journal of Biological Chemistry.
[28] R. Boucher,et al. Release of cellular UDP-glucose as a potential extracellular signaling molecule. , 2003, Molecular pharmacology.
[29] K. Jacobson,et al. Purine and pyrimidine (P2) receptors as drug targets. , 2002, Journal of medicinal chemistry.
[30] K. Jacobson,et al. Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. , 2002, Journal of medicinal chemistry.
[31] K. Palczewski,et al. Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.
[32] C. Schengrund,et al. UDP-6-deoxy-6-fluoro-alpha-D-galactose binds to two different galactosyltransferases, but neither can effectively catalyze transfer of the modified galactose to the appropriate acceptor. , 1999, Carbohydrate research.
[33] J. Ballesteros,et al. [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors , 1995 .
[34] G. Chang,et al. Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics , 1990 .
[35] T. K. Harden,et al. Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. , 1989, The Journal of biological chemistry.
[36] P. Hawkins,et al. Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. , 1988, The Biochemical journal.
[37] W. Prusoff,et al. Synthesis and antiviral evaluation of carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine. , 1988, Journal of medicinal chemistry.
[38] P. Kováč,et al. Synthesis and N.M.R. spectra of methyl 2-deoxy-2-fluoro- and 3-deoxy-3-fluoro-α- and β-d-glucopyranosides , 1987 .
[39] W. Szarek,et al. Synthesis of cyclopentane analogs of (2′- and 3′-deoxy-erythro-pentofuranosyl and ribofuranosyl)-2-thiouracil nucleosides , 1986 .
[40] P. J. Card. Fluorinated carbohydrates. Use of DAST in the synthesis of fluorinated sugars , 1983 .
[41] D. Macdonald. [11] Chemical synthesis of aldose 1-phosphates , 1966 .