论文信息 - Re: Combination of radiotherapy and immunotherapy? Do timing and dose matter?

Re: Combination of radiotherapy and immunotherapy? Do timing and dose matter?

Radiation and dual checkpoint blockade activate nonredundant immune mechanisms in cancer. Nature 2015; 520: 373–377. 5. Escorcia FE, Postow MA and Barker CA. Radiotherapy and immune checkpoint blockade for melanoma: a promising combinatorial strategy in need of further investigation. Cancer J 2017; 23: 32–39. 6. Qin R, Olson A, Singh B, et al. Safety and efficacy of radiation therapy in advanced melanoma patients treated with ipilimumab. Int J Radiat Oncol Biol Phys 2016; 96: 72–77. 7. Koller KM,Mackley HB, Liu J, et al. Improved survival and complete response rates in patients with advancedmelanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone. Cancer Biol Ther 2017; 18: 36–42. 8. Chicas-Sett R, Morales-Orue I, Rodriguez-Abreu D, et al. Combining radiotherapy and ipilimumab induces clinically relevant radiation-induced abscopal effects in metastatic melanoma patients: a systematic review. Clin Transl Radiat Oncol 2018; 9: 5–11.

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