Ocimum basilicum suspension culture as resource for bioactive triterpenoids: yield enrichment by elicitation and bioreactor cultivation

[1]  Najmeh Ahmadian Chashmi,et al.  Improved accumulation of betulin and betulinic acid in cell suspension culture of Betula pendula roth by abiotic and biotic elicitors , 2018, Preparative biochemistry & biotechnology.

[2]  M. K. Swamy,et al.  Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics , 2018, Applied Microbiology and Biotechnology.

[3]  N. Noor,et al.  Metabolite profiles of callus and cell suspension cultures of mangosteen , 2018, 3 Biotech.

[4]  Tasiu Isah,et al.  Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield , 2018, Plant Cell, Tissue and Organ Culture (PCTOC).

[5]  Alexandre Cardoso-Taketa,et al.  Methyl Jasmonate and Salicylic Acid Enhanced the Production of Ursolic and Oleanolic Acid in Callus Cultures of Lepechinia Caulescens , 2017, Pharmacognosy magazine.

[6]  Smita Srivastava,et al.  Elicitation: a stimulation of stress in in vitro plant cell/tissue cultures for enhancement of secondary metabolite production , 2017, Phytochemistry Reviews.

[7]  Huie Li,et al.  Transcriptomic analyses reveal biosynthetic genes related to rosmarinic acid in Dracocephalum tanguticum , 2017, Scientific Reports.

[8]  L. Zheng,et al.  Molecular characterization of an elicitor-responsive 3-hydroxy-3-methylglutaryl coenzyme A reductase gene involved in oleanolic acid production in cell cultures of Achyranthes bidentata , 2017, Plant Growth Regulation.

[9]  R. Eibl,et al.  Methyl jasmonate enhanced production of rosmarinic acid in cell cultures of Satureja khuzistanica in a bioreactor , 2016 .

[10]  Suaib Luqman,et al.  Advances in Boerhaavia diffusa hairy root technology: a valuable pursuit for identifying strain sensitivity and up-scaling factors to refine metabolite yield and bioactivity potentials , 2016, Protoplasma.

[11]  C. Zheng,et al.  Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites , 2016, Critical Reviews in Biotechnology.

[12]  L. Milella,et al.  Can Ocimum basilicum L. and Ocimum tenuiflorum L. in vitro culture be a potential source of secondary metabolites? , 2016, Food chemistry.

[13]  P. Pandey,et al.  Production of anti-cancer triterpene (betulinic acid) from callus cultures of different Ocimum species and its elicitation , 2015, Protoplasma.

[14]  Gun-Dong Kim,et al.  Production and applications of rosmarinic acid and structurally related compounds , 2015, Applied Microbiology and Biotechnology.

[15]  Lijia Xu,et al.  Transcriptional data mining of Salvia miltiorrhiza in response to methyl jasmonate to examine the mechanism of bioactive compound biosynthesis and regulation. , 2014, Physiologia plantarum.

[16]  M. Manickavasagam,et al.  Enhanced Biosynthesis of Withanolides by Elicitation and Precursor Feeding in Cell Suspension Culture of Withania somnifera (L.) Dunal in Shake-Flask Culture and Bioreactor , 2014, PloS one.

[17]  Juliane Steingroewer,et al.  Salvia suspension cultures as production systems for oleanolic and ursolic acid , 2014, Acta Physiologiae Plantarum.

[18]  Sumit Ghosh,et al.  Methyl Jasmonate-Elicited Transcriptional Responses and Pentacyclic Triterpene Biosynthesis in Sweet Basil1[C][W] , 2013, Plant Physiology.

[19]  Qiang Zhao,et al.  Growth and triterpenic acid accumulation of Cyclocarya paliurus cell suspension cultures , 2013, Biotechnology and Bioprocess Engineering.

[20]  Milen I Georgiev,et al.  Hosting the plant cells in vitro: recent trends in bioreactors , 2013, Applied Microbiology and Biotechnology.

[21]  F. Hakkim,et al.  Antioxidant property of leaves and calluses extracts of in-vitro grown 5 different Ocimum species , 2012 .

[22]  Mansour Ghaffari Moghaddam,et al.  Biological Activity of Betulinic Acid: A Review , 2012 .

[23]  M. Y. Suhaimi,et al.  Ursolic Acid and Oleanolic Acid Productions in Elicited Cell Suspension Cultures of Hedyotis corymbosa , 2012 .

[24]  R. Mathew.  Effect of methyl jasmonate and chitosan on growth characteristics of Ocimum basilicum L., Ocimum sanctum L. and Ocimum gratissimum L. cell suspension cultures , 2012 .

[25]  Hyuk Song,et al.  Production of rosmarinic acid in Ocimum sanctum (L.) cell suspension cultures by the influence of growth regulators , 2011 .

[26]  K. Bora,et al.  Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain. , 2011, Journal of ethnopharmacology.

[27]  U. Bora,et al.  Accumulation of betulinic, oleanolic, and ursolic acids in In vitro cell cultures of Lantana camara L. and their significant cytotoxic effects on HeLa cell lines , 2010 .

[28]  S. Begum,et al.  Anticancer Activity of Ocimum basilicum and the Effect of Ursolic Acid on the Cytoskeleton of MCF-7 Human Breast Cancer Cells , 2010 .

[29]  M. Długosz,et al.  Significant enhancement of oleanolic acid accumulation by biotic elicitors in cell suspension cultures of Calendula officinalis L. , 2010 .

[30]  D. McPhee,et al.  Molecules Best Paper Award 2013 , 2013, Molecules.

[31]  A. Marzouk.  Hepatoprotective Triterpenes from Hairy Root Cultures of Ocimum basilicum L. , 2009, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[32]  Milen I Georgiev,et al.  Optimization of Rosmarinic Acid Production by Lavandula vera MM Plant Cell Suspension in a Laboratory Bioreactor , 2008, Biotechnology progress.

[33]  D. Gang,et al.  A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomes. , 2008, The Plant journal : for cell and molecular biology.

[34]  S. Kintzios,et al.  Ocimum sp. (Basil): Botany, Cultivation, Pharmaceutical Properties, and Biotechnology , 2008 .

[35]  P. Džubák,et al.  Pharmacological activities of natural triterpenoids and their therapeutic implications. , 2006, Natural product reports.

[36]  Zhenjiang Zhao,et al.  Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate , 2006, Applied Microbiology and Biotechnology.

[37]  J. Zhong,et al.  High Density Cultivation of Panax notoginseng Cell Cultures with Methyl Jasmonate Elicitation in a Centrifugal Impeller Bioreactor , 2005 .

[38]  Jie Liu.  Oleanolic acid and ursolic acid: research perspectives. , 2005, Journal of ethnopharmacology.

[39]  Milen I Georgiev,et al.  Production of rosmarinic acid byLavandula vera MM cell suspension in bioreactor: effect of dissolved oxygen concentration and agitation , 2005 .

[40]  T. Ponce-Noyola,et al.  Induced accumulation of oleanolic acid and ursolic acid in cell suspension cultures of Uncaria tomentosa , 2005, Biotechnology Letters.

[41]  J. Zhong,et al.  Enhancement of ginsenoside biosynthesis in high-density cultivation of Panax notoginseng cells by various strategies of methyl jasmonate elicitation , 2005, Applied Microbiology and Biotechnology.

[42]  R. Tan,et al.  Simultaneous production of anthocyanin and triterpenoids in suspension cultures of Perilla frutescens , 2004 .

[43]  Milen Georgiev,et al.  Rosmarinic acid production by Lavandula vera MM cell suspension: the effect of temperature , 2004, Biotechnology Letters.

[44]  S. Kintzios,et al.  Scale-up micropropagation of sweet basil (Ocimum basilicum L.) in an airlift bioreactor and accumulation of rosmarinic acid , 2004, Biotechnology Letters.

[45]  Naser A. Arikat,et al.  Growth and rosmarinic acid accumulation in callus, cell suspension, and root cultures of wild Salvia fruticosa , 2003, Plant Cell, Tissue and Organ Culture.

[46]  S. Kintzios,et al.  In vitro rosmarinic acid accumulation in sweet basil (Ocimum basilicum L.) , 2003, Biotechnology Letters.

[47]  B. Bohanec,et al.  A preliminary investigation of ursolic acid in cell suspension culture of Salvia officinalis , 2000, Plant Cell, Tissue and Organ Culture.

[48]  P. Patnaik.  Penicillin Fermentation: Mechanisms and Models for Industrial-Scale Bioreactors , 2000, Critical reviews in biotechnology.

[49]  M. Petersen,et al.  Fungal elicitor preparations and methyl jasmonate enhance rosmarinic acid accumulation in suspension cultures of Coleus blumei , 1999, Plant Cell Reports.

[50]  Yoshie Murakami,et al.  Rosmarinic acid and related phenolics in hairy root cultures of Ocimum basilicum , 1996 .

[51]  M. Petersen,et al.  The biosynthesis of rosmarinic acid in suspension cultures of Coleus blumei , 1994, Plant Cell, Tissue and Organ Culture.

[52]  F. Skoog,et al.  A revised medium for rapid growth and bio assays with tobacco tissue cultures , 1962 .

[53]  P. Dwivedi,et al.  Methyl-jasmonate and salicylic acid as potent elicitors for secondary metabolite production in medicinal plants: A review , 2018 .

[54]  M. Rasha,et al.  In-vitro Production of Rosmarinic Acid from Basil ( Ocimum basilicum L . ) and Lemon Balm ( Melissa officinalis L . ) , 2015 .

[55]  F. Iqbal,et al.  Oral supplementation of Ocimum basilicum has the potential to improves the locomotory, exploratory, anxiolytic behavior and learning in adult male albino mice , 2014, Neurological Sciences.

[56]  W. Oleszek,et al.  The effects of jasmonic acid and methyl jasmonate on rosmarinic acid production in Mentha × piperita cell suspension cultures , 2011, Plant Cell, Tissue and Organ Culture (PCTOC).

[57]  P. Pereira,et al.  Enhanced triterpene production in Tabernaemontana catharinensis cell suspension cultures in response to biotic elicitors , 2007 .

[58]  Jian-Jiang Zhong,et al.  Scale‐Up of Centrifugal Impeller Bioreactor for Hyperproduction of Ginseng Saponin and Polysaccharide by High‐Density Cultivation of Panax notoginseng Cells , 2004 .

[59]  P. Andrade,et al.  Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.). , 2003, Journal of plant physiology.

[60]  B. Ulbrich,et al.  Large-Scale Production of Rosmarinic Acid from Plant Cell Cultures of Coleus blumei Benth. , 1985 .