Properties of docosahexaenoic-acid-containing lipids and their influence on the function of rhodopsin.

[1]  D. C. Mitchell,et al.  The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways , 2001, Journal of Molecular Neuroscience.

[2]  K. Gawrisch,et al.  Nuclear magnetic resonance investigation of hydrocarbon chain packing in bilayers of polyunsaturated phospholipids , 2007, Lipids.

[3]  S. Kiihne,et al.  Selective interface detection: mapping binding site contacts in membrane proteins by NMR spectroscopy. , 2005, Journal of the American Chemical Society.

[4]  Frank Suits,et al.  Role of cholesterol and polyunsaturated chains in lipid-protein interactions: molecular dynamics simulation of rhodopsin in a realistic membrane environment. , 2005, Journal of the American Chemical Society.

[5]  Michael F. Brown,et al.  Packing and Viscoelasticity of Polyunsaturated ω-3 and ω-6 Lipid Bilayers as Seen by 2H NMR and X-ray Diffraction , 2005 .

[6]  I. Alves,et al.  Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. , 2005, Biophysical journal.

[7]  M. Hyvönen,et al.  Molecular dynamics simulations of unsaturated lipid bilayers: effects of varying the numbers of double bonds , 2005, European Biophysics Journal.

[8]  Krzysztof Palczewski,et al.  Functional Characterization of Rhodopsin Monomers and Dimers in Detergents* , 2004, Journal of Biological Chemistry.

[9]  Krzysztof Palczewski,et al.  Oligomerization of G protein-coupled receptors: past, present, and future. , 2004, Biochemistry.

[10]  Alexander D. MacKerell,et al.  Molecular-level organization of saturated and polyunsaturated fatty acids in a phosphatidylcholine bilayer containing cholesterol. , 2004, Biochemistry.

[11]  W. Harris Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk? , 2004, Current atherosclerosis reports.

[12]  Martin Caffrey,et al.  Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. , 2004, Chemistry and physics of lipids.

[13]  Jonathan A Javitch,et al.  The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors , 2004, Molecular Pharmacology.

[14]  M. Lavialle,et al.  Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. , 2004, Reproduction, nutrition, development.

[15]  A. Engel,et al.  The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes , 2004, Molecular membrane biology.

[16]  T. Mielke,et al.  Electron crystallography reveals the structure of metarhodopsin I , 2004, The EMBO journal.

[17]  S. Shaikh,et al.  Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study. , 2004, Biophysical journal.

[18]  Hee-Yong Kim,et al.  Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response to n-3 Fatty Acid Deficiency* , 2004, Journal of Biological Chemistry.

[19]  Krzysztof Palczewski,et al.  A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface , 2004, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[20]  A. Engel,et al.  The G protein‐coupled receptor rhodopsin in the native membrane , 2004, FEBS letters.

[21]  T. Huber,et al.  Membrane model for the G-protein-coupled receptor rhodopsin: hydrophobic interface and dynamical structure. , 2004, Biophysical journal.

[22]  D. Im Discovery of new G protein-coupled receptors for lipid mediators Published, JLR Papers in Press, December 1, 2003. DOI 10.1194/jlr.R300006-JLR200 , 2004, Journal of Lipid Research.

[23]  Manfred Burghammer,et al.  Structure of bovine rhodopsin in a trigonal crystal form. , 2003, Journal of molecular biology.

[24]  W. Gordon,et al.  Strong Association of Unesterified [3H]Docosahexaenoic Acid and [3H-Docosahexaenoyl]Phosphatidate to Rhodopsin During In Vivo Labeling of Frog Retinal Rod Outer Segments , 2000, Neurochemical Research.

[25]  A. Dumaual,et al.  Acyl chain unsaturation in PEs modulates phase separation from lipid raft molecules. , 2003, Biochemical and biophysical research communications.

[26]  S. Wassall,et al.  Docosahexaenoic acid: membrane properties of a unique fatty acid. , 2003, Chemistry and physics of lipids.

[27]  Thomas B Woolf,et al.  Molecular dynamics simulation of dark-adapted rhodopsin in an explicit membrane bilayer: coupling between local retinal and larger scale conformational change. , 2003, Journal of molecular biology.

[28]  V. Cherezov,et al.  Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation? , 2003, Biochemistry.

[29]  S. Wassall,et al.  Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. , 2003, Archives of biochemistry and biophysics.

[30]  S. Feller,et al.  Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. , 2003, Journal of the American Chemical Society.

[31]  S. Feller,et al.  Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. , 2003, Journal of the American Chemical Society.

[32]  K. Gawrisch,et al.  The structure of DHA in phospholipid membranes , 2003, Lipids.

[33]  A. L. Rabinovich,et al.  Molecular dynamics simulations of hydrated unsaturated lipid bilayers in the liquid-crystal phase and comparison to self-consistent field modeling. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[34]  V. Cherezov,et al.  Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. , 2002, Biochemistry.

[35]  R. Thurmond,et al.  Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids. , 2002, Biochemistry.

[36]  M. Klein,et al.  Electrostatic interactions in a neutral model phospholipid bilayer by molecular dynamics simulations , 2002 .

[37]  T. Huber,et al.  Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations. , 2002, Journal of the American Chemical Society.

[38]  Alexander D. MacKerell,et al.  Polyunsaturated fatty acids in lipid bilayers: intrinsic and environmental contributions to their unique physical properties. , 2002, Journal of the American Chemical Society.

[39]  Martin Caffrey,et al.  Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation. , 2002, Biophysical journal.

[40]  K. Gawrisch,et al.  Effect of Unsaturated Lipid Chains on Dimensions, Molecular Order and Hydration of Membranes , 2001 .

[41]  B. Jeffrey,et al.  The role of docosahexaenoic acid in retinal function , 2001, Lipids.

[42]  K. Gawrisch,et al.  Dehydration induces lateral expansion of polyunsaturated 18:0-22:6 phosphatidylcholine in a new lamellar phase. , 2001, Biophysical journal.

[43]  B. Litman,et al.  Cholesterol dependent recruitment of di22:6-PC by a G protein-coupled receptor into lateral domains. , 2000, Biophysical journal.

[44]  J. Davis,et al.  1H and (13)C NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids. , 2000, Biophysical journal.

[45]  E. Evans,et al.  Effect of chain length and unsaturation on elasticity of lipid bilayers. , 2000, Biophysical journal.

[46]  E. Evans,et al.  Water permeability and mechanical strength of polyunsaturated lipid bilayers. , 2000, Biophysical journal.

[47]  S. Wassall,et al.  Molecular organization of cholesterol in polyunsaturated phospholipid membranes: a solid state 2H NMR investigation , 1999, FEBS letters.

[48]  R. Cantor,et al.  Lipid composition and the lateral pressure profile in bilayers. , 1999, Biophysical journal.

[49]  D. Huster,et al.  Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. , 1998, Biochemistry.

[50]  H. Strey,et al.  Membrane lateral compressibility determined by NMR and x-ray diffraction: effect of acyl chain polyunsaturation. , 1997, Biophysical journal.

[51]  D. Huster,et al.  Water permeability of polyunsaturated lipid membranes measured by 17O NMR. , 1997, Biophysical journal.

[52]  E. Ikonen,et al.  Functional rafts in cell membranes , 1997, Nature.

[53]  Teresa M. Sinnwell,et al.  2H nuclear magnetic resonance order parameter profiles suggest a change of molecular shape for phosphatidylcholines containing a polyunsaturated acyl chain. , 1995, Biophysical journal.

[54]  M. Brown,et al.  Modulation of Rhodopsin Function by Properties of the Membrane Bilayer , 2022 .

[55]  N. J. Gibson,et al.  Lipid headgroup and acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes. , 1993, Biochemistry.

[56]  M. Straume,et al.  Role of sn-1-saturated,sn-2-polyunsaturated phospholipids in control of membrane receptor conformational equilibrium: effects of cholesterol and acyl chain unsaturation on the metarhodopsin I in equilibrium with metarhodopsin II equilibrium. , 1992, Biochemistry.

[57]  A. L. Rabinovich,et al.  On the conformational, physical properties and functions of polyunsaturated acyl chains. , 1991, Biochimica et biophysica acta.

[58]  J. Glomset,et al.  Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. , 1986, Journal of lipid research.