Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats

[1]  S. Samarghandian,et al.  Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients , 2014, Pharmacognosy research.

[2]  R. Afshari,et al.  Evaluation of Lung and Bronchoalveolar Lavage Fluid Oxidative Stress Indices for Assessing the Preventing Effects of Safranal on Respiratory Distress in Diabetic Rats , 2014, TheScientificWorldJournal.

[3]  S. Samarghandian,et al.  Effects of Cichorium intybus linn on blood glucose, lipid constituents and selected oxidative stress parameters in streptozotocin-induced diabetic rats. , 2014, Cardiovascular & hematological disorders drug targets.

[4]  S. Samarghandian,et al.  Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver , 2013, Biogerontology.

[5]  M. Golechha,et al.  Crocus sativus L. (saffron) attenuates isoproterenol-induced myocardial injury via preserving cardiac functions and strengthening antioxidant defense system. , 2012, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[6]  M. Golechha,et al.  Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia–reperfusion injury in rats , 2012, European Journal of Nutrition.

[7]  M. Hashizume,et al.  Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors. , 2012, Cytokine.

[8]  H. Sadeghnia,et al.  Effects of Saffron (Crocus sativus L.) and its Active Constituent, Crocin, on Recognition and Spatial Memory after Chronic Cerebral Hypoperfusion in Rats , 2012, Phytotherapy research : PTR.

[9]  S. Funk,et al.  Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes , 2012, International journal of vascular medicine.

[10]  H. Sahraei,et al.  Saffron (Crocus sativus) Aqueous Extract and its Constituent Crocin Reduces Stress‐induced Anorexia in Mice , 2011, Phytotherapy research : PTR.

[11]  Mohajeri Daryoush,et al.  Attenuation of oxidative stress of hepatic tissue by ethanolic extract of saffron (dried stigmas of Crocus sativus L.) in streptozotocin (STZ)-induced diabetic rats , 2011 .

[12]  S. Kianbakht,et al.  Anti-hyperglycemic Effects of Saffron and its Active Constituents, Crocin and Safranal, in Alloxan-Induced Diabetic Rats , 2011 .

[13]  W. Mayhan,et al.  Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. , 2011, American journal of physiology. Heart and circulatory physiology.

[14]  Maria Tsachaki,et al.  Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection , 2011, Behavioural Brain Research.

[15]  S. Samarghandian,et al.  Suppression of Pulmonary Tumor Promotion and Induction of Apoptosis by Crocus sativus L. Extraction , 2011, Applied biochemistry and biotechnology.

[16]  S. Srichairatanakool,et al.  Effects of Phenolic Compounds of Fermented Thai Indigenous Plants on Oxidative Stress in Streptozotocin-Induced Diabetic Rats , 2011, Evidence-based complementary and alternative medicine : eCAM.

[17]  Enas A. Hamed,et al.  Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators , 2011, Journal of Physiology and Biochemistry.

[18]  L. Chuang,et al.  The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. , 2010, American journal of translational research.

[19]  C. Apovian,et al.  Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. , 2009, Journal of the American College of Cardiology.

[20]  N. Calcutt,et al.  Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials , 2009, Nature Reviews Drug Discovery.

[21]  Srijit Das,et al.  The Effects of Palm Oil Tocotrienol-Rich Fraction Supplementation on Biochemical Parameters, Oxidative Stress and the Vascular Wall of Streptozotocin-Induced Diabetic Rats , 2009, Clinics.

[22]  S. Bakker,et al.  Does the metabolic syndrome add to the diagnosis and treatment of cardiovascular disease? , 2008, Nature Clinical Practice Cardiovascular Medicine.

[23]  R. de Cabo,et al.  Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. , 2008, American journal of physiology. Heart and circulatory physiology.

[24]  M. Fowler.  Microvascular and Macrovascular Complications of Diabetes , 2008, Clinical Diabetes.

[25]  A. Ardestani,et al.  Experimental diabetes treated with Achillea santolina: effect on pancreatic oxidative parameters. , 2007, Journal of ethnopharmacology.

[26]  N. Agrawal,et al.  Atherosclerosis in diabetes mellitus: role of inflammation. , 2007, Indian journal of medical sciences.

[27]  Min Yang,et al.  Crocetin prevents AGEs-induced vascular endothelial cell apoptosis. , 2006, Pharmacological research.

[28]  Z. Ungvari,et al.  Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: role of NF-κB inhibition , 2006 .

[29]  H. Hosseinzadeh,et al.  EFFECTS OF CROCUS SATIVUS STIGMA EXTRACT AND ITS CONSTITUENTS, CROCIN AND SAFRANAL, ON INTACT MEMORY AND SCOPOLAMINE-INDUCED LEARNING DEFICITS IN RATS PERFORMING THE MORRIS WATER MAZE TASK , 2006 .

[30]  L. Sheng,et al.  Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. , 2006, European journal of pharmacology.

[31]  L. Hung,et al.  Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. , 2006, American journal of physiology. Endocrinology and metabolism.

[32]  A. Assimopoulou,et al.  Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents , 2005, Phytotherapy research : PTR.

[33]  J. Coresh,et al.  Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities study. , 2005, Diabetes care.

[34]  Z. Ungvari,et al.  Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging. , 2005, Current vascular pharmacology.

[35]  R. Natarajan,et al.  Lipid inflammatory mediators in diabetic vascular disease. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[36]  R. Virmani,et al.  Morphologic Findings of Coronary Atherosclerotic Plaques in Diabetics: A Postmortem Study , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[37]  M. Brownlee.  A radical explanation for glucose-induced β cell dysfunction , 2003 .

[38]  J. Navarro,et al.  Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. , 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[39]  N. Baquer,et al.  Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonella foenum graecum) , 2002, Molecular and Cellular Biochemistry.

[40]  H. Hosseinzadeh,et al.  Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice , 2002, BMC pharmacology.

[41]  M. Brownlee.  Biochemistry and molecular cell biology of diabetic complications , 2001, Nature.

[42]  I. Goldberg.  Diabetic Dyslipidemia: Causes and Consequences , 2001 .

[43]  G. Pacini,et al.  Course of renal function in type 2 diabetic patients with abnormalities of albumin excretion rate. , 2000, Diabetes.

[44]  M. El-Missiry,et al.  Enhanced testicular antioxidant system by ascorbic acid in alloxan diabetic rats. , 1999, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[45]  M. Netea,et al.  High glucose concentrations increase the tumor necrosis factor-alpha production capacity by human peripheral blood mononuclear cells. , 1998, Romanian journal of physiology : physiological sciences.

[46]  M. Ravid,et al.  Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. , 1998, Archives of internal medicine.

[47]  J. Reyes,et al.  Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. , 1998, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[48]  M. Recio,et al.  An Update Review of Saffron and its Active Constituents , 1996 .

[49]  G. Pieper,et al.  Peroxidative Stress in Diabetic Blood Vessels: Reversal by Pancreatic Islet Transplantation , 1995, Diabetes.

[50]  A. Gotlieb,et al.  Expression of tumour necrosis factor alpha and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy. , 1995, British heart journal.

[51]  M. Díaz-Guerra,et al.  Nitric oxide is released in regenerating liver after partial hepatectomy , 1995, Hepatology.

[52]  M. Cybulsky,et al.  Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. , 1991, Science.

[53]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[54]  S. Marklund,et al.  Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. , 1974, European journal of biochemistry.

[55]  G. Ellman,et al.  Tissue sulfhydryl groups. , 1959, Archives of biochemistry and biophysics.

[56]  R. Afshari,et al.  Expression of Concern Expression of Concern on “Crocus sativus L. (Saffron) Stigma Aqueous Extract Induces Apoptosis in Alveolar Human Lung Cancer Cells through Caspase-Dependent Pathways Activation” , 2019 .

[57]  C. Stefanadis,et al.  Diabetes mellitus and vascular endothelial dysfunction: current perspectives. , 2012, Current vascular pharmacology.

[58]  A. Aliyev,et al.  EFFECTS OF HYDROMETHANOLIC EXTRACT OF SAFFRON (CROCUS SATIVUS) ON SERUM GLUCOSE, INSULIN AND CHOLESTEROL LEVELS IN HEALTHY MALE RATS , 2010 .

[59]  T. Dunning.  Periodontal disease--the overlooked diabetes complication. , 2009, Nephrology nursing journal : journal of the American Nephrology Nurses' Association.

[60]  Z. Ungvari,et al.  Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. , 2006, American journal of physiology. Heart and circulatory physiology.

[61]  A. Ergul,et al.  Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. , 2005, Cardiovascular diabetology.

[62]  Niacin A N D Riboflavin.  Disturbances of micronutrient and antioxidant status in diabetes , 2005 .

[63]  M. Brownlee.  A radical explanation for glucose-induced beta cell dysfunction. , 2003, The Journal of clinical investigation.

[64]  A. Ortiz,et al.  Involvement of tumor necrosis factor-alpha in the pathogenesis of experimental and human glomerulonephritis. , 1995, Advances in nephrology from the Necker Hospital.

[65]  H. Aebi,et al.  Catalase in vitro. , 1984, Methods in enzymology.