Pain and fatigue after concentric and eccentric muscle contractions.

1. Normal subjects performed a step test in which the quadriceps of one leg contracted concentrically while the contralateral muscle contracted eccentrically. 2. Maximal voluntary force and the force: frequency relationship were altered bilaterally as a result of the exercise, the changes being greater in the muscle which had contracted eccentrically. Recovery occurred over 24 h. 3. Electromyographic studies using three sites on each muscle showed an increase in electrical activation during the exercise only in the muscle which was contracting eccentrically. Recovery followed a time course similar to that of the contractile properties. 4. Pain and tenderness developed only in the muscle which had contracted eccentrically. Pain was first noted approximately 8 h after exercise and was maximal at approximately 48 h after exercise, at which time force generation and electrical activation had returned to pre-exercise values. 5. Eccentric contractions cause more profound changes in some aspects of muscle function than concentric contractions. These changes cannot be explained in simple metabolic terms, and it is suggested that they are the result of mechanical trauma caused by the high tension generated in relatively few active fibres during eccentric contractions.

[1]  T. Hough.  ERGOGRAPHIC STUDIES IN MUSCULAR FATIGUE AND SORENESS. , 1900, Journal. Boston Society of Medical Sciences.

[2]  B. Katz.  The relation between force and speed in muscular contraction , 1939, The Journal of physiology.

[3]  B. C. Abbott,et al.  The physiological cost of negative work , 1952, The Journal of physiology.

[4]  E. Asmussen,et al.  Positive and negative muscular work. , 1953, Acta physiologica Scandinavica.

[5]  O. Lippold,et al.  The relation between force, velocity and integrated electrical activity in human muscles , 1954, The Journal of physiology.

[6]  E. Asmussen,et al.  Observations on experimental muscular soreness. , 1956, Acta rheumatologica Scandinavica.

[7]  D. Ha.  Quantitative electromyographic investigation of the spasm theory of muscle pain. , 1966 .

[8]  H P Clamann,et al.  Activity of single motor units during isometric tension , 1970, Neurology.

[9]  K Klausen,et al.  Oxygen uptake and heart rate responses to exercise performed with concentric and eccentric muscle contractions. , 1971, Medicine and science in sports.

[10]  P V Komi,et al.  Effect of eccentric and concentric muscle conditioning on tension and electrical activity of human muscle. , 1972, Ergonomics.

[11]  C T Davies,et al.  Negative (eccentric) work. II. Physiological responses to walking uphill and downhill on a motor-driven treadmill. , 1972, Ergonomics.

[12]  R. E. Davies,et al.  Chemical and mechanical changes during stretching of activated frog skeletal muscle , 1973 .

[13]  P. V. Komi,et al.  Relationship between Muscle Tension, EMG and Velocity of Contraction under Concentric and Eccentric Work , 1973 .

[14]  R. Stein,et al.  The contractile properties of human motor units during voluntary isometric contractions , 1973, The Journal of physiology.

[15]  P V Komi,et al.  Quantitative evaluation of mechanical and electrical changes during fatigue loading of eccentric and concentric work. , 1974, Scandinavian journal of rehabilitation medicine. Supplement.

[16]  B Bigland-Ritchie,et al.  Integrated electromyogram and oxygen uptake during positive and negative work. , 1976, The Journal of physiology.

[17]  W. Abraham.  Factors in delayed muscle soreness. , 1976, Medicine and science in sports.

[18]  P A Merton,et al.  Fatigue of long duration in human skeletal muscle after exercise. , 1977, The Journal of physiology.

[19]  D. Jones,et al.  Human skeletal muscle function: description of tests and normal values. , 1977, Clinical science and molecular medicine.

[20]  T. Kumazawa,et al.  Thin‐fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog , 1977, The Journal of physiology.

[21]  The Contractile Properties and Fatigue of the Diaphragm in Man , 1980 .

[22]  J. Moxham,et al.  Contractile properties and fatigue of the diaphragm in man. , 1981, Thorax.

[23]  D. Jones,et al.  Muscle fatigue due to changes beyond the neuromuscular junction. , 1981, Ciba Foundation symposium.

[24]  D. Newham,et al.  Measurement of severity and distribution of experimental muscle tenderness , 1981 .