Glyphosate contamination in grains and foods: An overview

Abstract Glyphosate is an active ingredient in most herbicides utilized for the purpose of weed control and desiccation on cereal and other grain crops in the U.S. and globally. Glyphosate residues in these products are causing public health concerns regarding its exposure. This review focuses on glyphosate applications for grain crops and contamination in relevant products. Topics include: brief history of glyphosate, glyphosate safety issues and health concerns, regulations regarding glyphosate maximum residue limits (MRLs), glyphosate quantification and residue analysis, its degradation during grain and food processing, and water contamination. Although herbicide degradation is reported during post-harvest grain processing, there lacks consensus to support glyphosate degradation in cereal grains through these processes. Animal trials found that high doses of glyphosate damaged the organs, reproduction and nerve systems; however, limited human evidence supports the carcinogenicity of glyphosate exposure on humans. Due to primary application of glyphosate in agriculture, glyphosate has recovered from environmental samples such as water. Overall, glyphosate residues in grains and foods were below the current MRLs. More studies are needed to further elucidate any health-related concerns pertaining to glyphosate exposure and consumption, degradation of glyphosate during grain storage and processing, as well as its long-term safety.

[1]  M. Bennis,et al.  Learning and memory impairments associated to acetylcholinesterase inhibition and oxidative stress following glyphosate based-herbicide exposure in mice. , 2019, Toxicology.

[2]  J. Zarn,et al.  Glyphosate residues in Swiss market foods: monitoring and risk evaluation , 2018, Food additives & contaminants. Part B, Surveillance.

[3]  Horacio Zagarese,et al.  New evidences of Roundup® (glyphosate formulation) impact on the periphyton community and the water quality of freshwater ecosystems , 2010, Ecotoxicology.

[4]  H. Köksel,et al.  Residue levels of malathion and its metabolites and fenitrothion in post-harvest treated wheat during storage, milling, and baking , 2005 .

[5]  M. Skidmore,et al.  Pesticides report 31: Effects of storage and processing on pesticide residues in plant products (Technical Report) , 1994 .

[6]  J. Costa,et al.  Environmental fate of glyphosate and aminomethylphosphonic acid in surface waters and soil of agricultural basins. , 2013, Chemosphere.

[7]  M. Rodrigo,et al.  Electrochemically assisted remediation of pesticides in soils and water: a review. , 2014, Chemical reviews.

[8]  P. Gélinas,et al.  Wheat preharvest herbicide application, whole‐grain flour properties, yeast activity and the degradation of glyphosate in bread , 2018 .

[9]  A. O. Maldaner,et al.  Direct Determination of N-Nitrosoglyphosate in Technical Glyphosate Using Ion Chromatography with UV Detection , 2016 .

[10]  A. I. García-Valcárcel,et al.  Determination of cereal herbicide residues in environmental samples by gas chromatography. , 1996, Journal of chromatography. A.

[11]  D. Weisenburger,et al.  Integrative assessment of multiple pesticides as risk factors for non-Hodgkin’s lymphoma among men , 2003, Occupational and environmental medicine.

[12]  A. Vinggaard,et al.  Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis. , 2018, Reproductive toxicology.

[13]  M. Rüther,et al.  Glyphosate in German adults - Time trend (2001 to 2015) of human exposure to a widely used herbicide. , 2017, International journal of hygiene and environmental health.

[14]  Qingbiao Zhao,et al.  Sensitive and rapid determination of glyphosate, glufosinate, bialaphos and metabolites by UPLC-MS/MS using a modified Quick Polar Pesticides Extraction method. , 2018, Forensic science international.

[15]  Chunmei Li,et al.  Effect of glyphosate on reproductive organs in male rat. , 2016, Acta histochemica.

[16]  M. Ibáñez,et al.  Direct liquid chromatography-tandem mass spectrometry determination of underivatized glyphosate in rice, maize and soybean. , 2013, Journal of chromatography. A.

[17]  A. Nougadère,et al.  Validation and application of analytical method for glyphosate and glufosinate in foods by liquid chromatography-tandem mass spectrometry. , 2018, Journal of chromatography. A.

[18]  P. Shah,et al.  Effect of Storage and Processing on Dissipation of Five Insecticides on Wheat , 2008 .

[19]  P. Capel,et al.  Trends in pesticide use on soybean, corn and cotton since the introduction of major genetically modified crops in the United States. , 2016, Pest management science.

[20]  I. Shaw,et al.  The effect of Saccharomyces cerevisiae on the stability of the herbicide glyphosate during bread leavening , 2005, Letters in applied microbiology.

[21]  W. Battaglin,et al.  Glyphosate and Its Degradation Product AMPA Occur Frequently and Widely in U.S. Soils, Surface Water, Groundwater, and Precipitation , 2014 .

[22]  Junze Liu,et al.  Effects of glyphosate on the ovarian function of pregnant mice, the secretion of hormones and the sex ratio of their fetuses. , 2018, Environmental pollution.

[23]  Dean G. Thompson,et al.  Ecological Risk Assessment for Aquatic Organisms from Over-Water Uses of Glyphosate , 2003, Journal of toxicology and environmental health. Part B, Critical reviews.

[24]  M. G. O'Keeffe The control of Agropyron repens and broad-leaved weeds pre-harvest of wheat and barley with the isopropylamine salt of glyphosate. , 1980 .

[25]  S. Duke,et al.  Glyphosate: a once-in-a-century herbicide. , 2008, Pest management science.

[26]  J. Awika,et al.  Complementary effects of cereal and pulse polyphenols and dietary fiber on chronic inflammation and gut health. , 2018, Food & function.

[27]  Frederique Istace,et al.  Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC , 2017, Archives of Toxicology.

[28]  R. Sammons,et al.  Glyphosate: Discovery, Development, Applications, and Properties , 2010 .

[29]  Anwaar Ahmed,et al.  Wheat Contaminants (Pesticides) and their Dissipation during Processing , 2014 .

[30]  Allan T Woodburn,et al.  Glyphosate: production, pricing and use worldwide , 2000 .

[31]  John K. Horowitz,et al.  "No-Till" Farming Is a Growing Practice , 2012 .

[32]  K. Granby,et al.  Analysis of glyphosate residues in cereals using liquid chromatography-mass spectrometry (LC-MS/MS) , 2003, Food additives and contaminants.

[33]  E. Maturano,et al.  Association between Cancer and Environmental Exposure to Glyphosate , 2017 .

[34]  Y. Iwata,et al.  Determination of glyphosate and (aminomethyl)phosphonic acid in soil, plant and animal matrices, and water by capillary gas chromatography with mass-selective detection. , 1994 .

[35]  A. Székács,et al.  Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels , 2016, International journal of environmental research and public health.

[36]  J. Lydon,et al.  Glyphosate Effects on Plant Mineral Nutrition, Crop Rhizosphere Microbiota, and Plant Disease in Glyphosate-Resistant Crops , 2012, Journal of agricultural and food chemistry.

[37]  A. Santilio,et al.  Determination of glyphosate residue in maize and rice using a fast and easy method involving liquid chromatography–mass spectrometry (LC/MS/MS) , 2019, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

[38]  C. Benbrook Trends in glyphosate herbicide use in the United States and globally , 2016, Environmental Sciences Europe.

[39]  Kirk Howatt,et al.  Glyphosate applied preharvest induces shikimic acid accumulation in hard red spring wheat (Triticum aestivum). , 2003, Journal of agricultural and food chemistry.

[40]  R. Tarone On the International Agency for Research on Cancer classification of glyphosate as a probable human carcinogen. , 2018, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[41]  G. DeNucci,et al.  Brief review analytical methods for the determination of glyphosate , 2018 .

[42]  F. Maggi,et al.  Glyphosate dispersion, degradation, and aquifer contamination in vineyards and wheat fields in the Po Valley, Italy. , 2018, Water research.

[43]  Alan D Baylis,et al.  Why glyphosate is a global herbicide: strengths, weaknesses and prospects , 2000 .

[44]  Shaohua Chen,et al.  Recent advances in glyphosate biodegradation , 2018, Applied Microbiology and Biotechnology.

[45]  M. Sanden,et al.  Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans. , 2014, Food chemistry.

[46]  B. Young,et al.  Changes in Herbicide Use Patterns and Production Practices Resulting from Glyphosate-Resistant Crops1 , 2006, Weed Technology.

[47]  R. A. Baumann,et al.  Rapid determination of glyphosate in cereal samples by means of pre-column derivatisation with 9-fluorenylmethyl chloroformate and coupled-column liquid chromatography with fluorescence detection. , 1999, Journal of chromatography. A.

[48]  Laura N. Vandenberg,et al.  Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement , 2016, Environmental Health.

[49]  Y. Lo,et al.  Simultaneous quantification of glyphosate, glufosinate, and their major metabolites in rice and soybean sprouts by gas chromatography with pulsed flame photometric detector. , 2004, Journal of agricultural and food chemistry.

[50]  Fern,et al.  Survey of Glyphosate Residues in Honey, Corn and Soy Products , 2014 .

[51]  J. Mandel,et al.  Epidemiologic studies of glyphosate and non-cancer health outcomes: a review. , 2011, Regulatory toxicology and pharmacology : RTP.

[52]  D. Shah,et al.  Amino acid biosynthesis inhibitors as herbicides. , 1988, Annual review of biochemistry.

[53]  J. Shah,et al.  Flow injection spectrophotometric determination of glyphosate herbicide in wheat grains via condensation reaction with p-dimethylaminobenzaldehyde , 2018 .

[54]  L. Theuvsen,et al.  Uses and benefits of glyphosate in German arable farming , 2012 .

[55]  J. Tadeo,et al.  Analysis of herbicide residues in cereals, fruits and vegetables. , 2000, Journal of chromatography. A.

[56]  V. Nandula Herbicide Resistance: Definitions and Concepts , 2010 .

[57]  I. Leito,et al.  Study of liquid chromatography/electrospray ionization mass spectrometry matrix effect on the example of glyphosate analysis from cereals. , 2011, Rapid communications in mass spectrometry : RCM.

[58]  N. Amrhein,et al.  The Site of the Inhibition of the Shikimate Pathway by Glyphosate: II. INTERFERENCE OF GLYPHOSATE WITH CHORISMATE FORMATION IN VIVO AND IN VITRO. , 1980, Plant physiology.

[59]  D. Weisenburger,et al.  Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA) , 2016, Journal of Epidemiology & Community Health.

[60]  S. Tittlemier,et al.  Evaluation of a Commercially Available Enzyme‐Linked Immunosorbent Assay and a Liquid Chromatography–Tandem Mass Spectrometric Method for the Analysis of Glyphosate in Wheat, Oats, Barley, Malt, and Lentils , 2017 .

[61]  A. Balinova,et al.  Effect of grain storage and processing on chlorpyrifos-methyl and pirimiphos-methyl residues in post-harvest-treated wheat with regard to baby food safety requirements , 2006, Food additives and contaminants.

[62]  R. Mesnage,et al.  Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity. , 2013, Toxicology.