DOCK4, a GTPase Activator, Is Disrupted during Tumorigenesis

[1]  K. Vuori,et al.  Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity , 2002, Journal of Cell Science.

[2]  Yuan Chang.  Representational Difference Analysis , 2002, Current protocols in molecular biology.

[3]  M. Schwartz,et al.  Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins , 2002, Nature Cell Biology.

[4]  Silvia Massari,et al.  Invasive behaviour of glioblastoma cell lines is associated with altered organisation of the cadherin-catenin adhesion system. , 2002, Journal of cell science.

[5]  Gerald R. Fink,et al.  Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex , 2002, Nature Cell Biology.

[6]  J. Cyster,et al.  The CDM protein DOCK2 in lymphocyte migration. , 2002, Trends in cell biology.

[7]  D. Schubert,et al.  A novel mechanism for the regulation of amyloid precursor protein metabolism , 2002, The Journal of cell biology.

[8]  E. Fearon,et al.  Cadherin and catenin alterations in human cancer , 2002, Genes, chromosomes & cancer.

[9]  Elaine Fuchs,et al.  Intercellular adhesion, signalling and the cytoskeleton , 2002, Nature Cell Biology.

[10]  N. Brown,et al.  Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion , 2002, Science.

[11]  I. Campbell,et al.  Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers , 2001, Nature Genetics.

[12]  Toshikazu Shirai,et al.  Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration , 2001, Nature.

[13]  K. Sekiguchi,et al.  Laminin-10/11 and Fibronectin Differentially Regulate Integrin- dependent Rho and Rac Activation via p130Cas-CrkII-DOCK180 Pathway* , 2001, The Journal of Biological Chemistry.

[14]  Joe W. Gray,et al.  Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Jacks,et al.  The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. , 2001, Developmental cell.

[16]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[17]  J. Bos,et al.  Rap1 signalling: adhering to new models , 2001, Nature Reviews Molecular Cell Biology.

[18]  E. Green,et al.  Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31 , 2001, Nature Genetics.

[19]  Matthew L. Albert,et al.  αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells , 2000, Nature Cell Biology.

[20]  L. Van Aelst,et al.  Rho GTPases: signaling, migration, and invasion. , 2000, Experimental cell research.

[21]  Eric S. Lander,et al.  Genomic analysis of metastasis reveals an essential role for RhoC , 2000, Nature.

[22]  L. Van Aelst,et al.  The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[23]  D. Schubert,et al.  Isolation and Characterization of Novel Presenilin Binding Protein , 2000, Journal of neurochemistry.

[24]  H. Liang,et al.  Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. , 2000, Genomics.

[25]  H. Horvitz,et al.  CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans , 2000, Nature Cell Biology.

[26]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[27]  M. Matsuda,et al.  Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. , 1999, Biochimica et biophysica acta.

[28]  I. Hariharan,et al.  The Rap1 GTPase functions as a regulator of morphogenesis in vivo , 1999, The EMBO journal.

[29]  G. Christofori,et al.  The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. , 1999, Trends in biochemical sciences.

[30]  M. Matsuda,et al.  Activation of Rac1 by a Crk SH3-binding protein, DOCK180. , 1998, Genes & development.

[31]  J. Settleman,et al.  Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. , 1998, Genes & development.

[32]  Michiyuki Matsuda,et al.  Evidence That DOCK180 Up-regulates Signals from the CrkII-p130Cas Complex* , 1998, The Journal of Biological Chemistry.

[33]  T. Jacks,et al.  Tumor suppressor mutations in mice: the next generation. , 1998, Current opinion in genetics & development.

[34]  T. Jacks,et al.  Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. , 1998, Genes & development.

[35]  H. Horvitz,et al.  C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 , 1998, Nature.

[36]  Anthony E. Reeve,et al.  E-cadherin germline mutations in familial gastric cancer , 1998, Nature.

[37]  Gerhard Christofori,et al.  A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.

[38]  K. Anderson,et al.  Regulated nuclear import of Rel proteins in the Drosophila immune response , 1998, Nature.

[39]  C. Der,et al.  Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K , 1997, Nature.

[40]  E. Fearon.  Human cancer syndromes: clues to the origin and nature of cancer. , 1997, Science.

[41]  Carl W. Miller,et al.  Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer , 1997, Genes, chromosomes & cancer.

[42]  H. Yao,et al.  cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway , 1997, Cell.

[43]  W. K. Alfred Yung,et al.  Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers , 1997, Nature Genetics.

[44]  M. Wigler,et al.  PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.

[45]  J. Best,et al.  Insulin receptor expression in bone , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[46]  M. Shibuya,et al.  DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane , 1996, Molecular and cellular biology.

[47]  D. Bostwick,et al.  Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression. , 1995, Cancer research.

[48]  N. Lisitsyn,et al.  Representational difference analysis: finding the differences between genomes. , 1995, Trends in genetics : TIG.

[49]  M. Bittner,et al.  Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Minna,et al.  Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. , 1995, Cancer research.

[51]  M. Skolnick,et al.  A cell cycle regulator potentially involved in genesis of many tumor types. , 1994, Science.

[52]  M. Wigler,et al.  Cloning the differences between two complex genomes , 1993, Science.

[53]  G. Rubin,et al.  The Drosophila Roughened mutation: Activation of a rap homolog disrupts eye development and interferes with cell determination , 1991, Cell.

[54]  D. Housman,et al.  Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus , 1990, Cell.

[55]  H. Kitayama,et al.  A ras-related gene with transformation suppressor activity , 1989, Cell.

[56]  T. Dryja,et al.  Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[57]  T. P. Dryja,et al.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma , 1983, Nature.

[58]  Joe W. Gray,et al.  Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas , 2001, Nature Genetics.

[59]  M. Schwartz,et al.  Determination of GTP loading on Rho. , 2000, Methods in enzymology.

[60]  M. Wigler,et al.  Representational difference analysis in detection of genetic lesions in cancer. , 1995, Methods in enzymology.

[61]  M. Wigler,et al.  Detection of genetic loss in tumors by representational difference analysis. , 1994, Cold Spring Harbor symposia on quantitative biology.