Hormonal control of pancreatic endocrine and exocrine secretion.

The known inhibitory effect of glucagon on pancreatic exocrine secretion has recently been applied to the treatment of acute pancreatitis'. The use of this promising therapeutic agent follows considerable advances made in recent years in the understanding of the hormonal control of pancreatic endocrine and exocrine secretion. Mechanisms of autonomic nervous control and of neuro-hormonal interactions in the pancreas have recently been reviewed by Brooks2 and Dupr63. Three questions about the hormonal control of pancreatic secretion need to be asked: How do pancreatic hormones (insulin and glucagon) affect exocrine pancreatic function (endocrine-exocrine interactions); how do hormones from the gastrointestinal mucosa affect endocrine function of the pancreas (entero-endocrine reactions); how do gastrointestinal hormones affect exocrine pancreatic function (entero-exocrine interactions)?

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