Recent topics of lung neuroendocrine tumors.

Pulmonary neuroendocrine tumors (NET), a subtype of lung cancer, comprises typical carcinoids (TCs), atypical carcinoids (ACs), large cell neuroendocrine carcinoma (LCNEC), and small cell lung carcinoma (SCLC). TCs and ACs are low-to-intermediate malignant tumors, on the other hand LCNEC and SCLC are high-grade carcinomas (1).

[1]  A. Marchevsky,et al.  RE: Spread Through Air Spaces (STAS) is Prognostic in Atypical Carcinoid, Large Cell Neuroendocrine Carcinoma, and Small Cell Carcinoma of the Lung. , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[2]  E. Smit,et al.  Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC). , 2019, Lung cancer.

[3]  A. Scarpa,et al.  Exploring the molecular and biological background of lung neuroendocrine tumours. , 2019, Journal of thoracic disease.

[4]  Ji-Youn Han,et al.  Association of PD‐L1 Expression with Tumor‐Infiltrating Immune Cells and Mutation Burden in High‐Grade Neuroendocrine Carcinoma of the Lung , 2018, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[5]  F. Tanaka,et al.  Predictive factors of postoperative survival among patients with pulmonary neuroendocrine tumor. , 2018, Journal of thoracic disease.

[6]  N. Socci,et al.  Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma–like and Non–Small Cell Carcinoma–like Subsets , 2016, Clinical Cancer Research.

[7]  J. McQuade,et al.  Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. , 2016, Cancer discovery.

[8]  W. Travis.  Advances in neuroendocrine lung tumors. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.