An investigation of space and space-time clustering in a large sample of infants with neural tube defects born in Cardiff.

Altogether 406 infants with neural tube defects born in Cardiff between 1956-71 were investigated for evidence of space-time clustering and 100 similarly affected infants, together with matched controls born in Cardiff between 1964-66 were investigated for evidence of spatial clustering. No evidence of excessive prevalence in either dimension was observed.

[1]  M. Pleydell.  Anencephaly and Other Congenital Abnormalities , 1960, British medical journal.

[2]  C. Roberts,et al.  A test for space clustering and its application to congenital limb defects in Cardiff. , 1973, British journal of preventive & social medicine.

[3]  G. Knox,et al.  Detection of Low Intensity Epidemicity , 1963, British journal of preventive & social medicine.

[4]  C. Carter,et al.  Major central nervous system malformations in South Wales. I. Incidence, local variations and geographical factors. , 1968, British journal of preventive & social medicine.

[5]  J. Fedrick,et al.  Malformations of the central nervous system in Glasgow. An examination of the evidence for clustering in space and time. , 1971, British journal of preventive & social medicine.

[6]  C. Lowe,et al.  Incidence of congenital defects in South Wales, 1964-6. , 1971, British journal of preventive & social medicine.

[7]  A. Polman.  Anencephaly, spina bifida and hydrocephaly , 1951, Genetica.

[8]  M. Aylett,et al.  Neural tube defects in a country town , 1974, British journal of preventive & social medicine.

[9]  Neural tube defects in Quebec. A search for evidence of 'clustering' in time and place. , 1972, British journal of preventive & social medicine.