Risperidone-induced cholestatic hepatitis.

Risperidone, a widely used atypical and potent neuroleptic drug, is assumed to induce fewer hepatic side-effects than phenothiazine anti-psychotics. Recently, we observed a case of risperidone-induced cholestatic hepatotoxicity. A 37-year-old male developed a rapid increase in liver enzymes and cholestatic parameters after starting treatment with risperidone for paranoid psychosis. Work-up for other potential aetiologies was negative. The results of a percutaneous liver biopsy were consistent with drug-induced liver injury and cholestasis. Over the course of one month after the discontinuance of all anti-psychotic agents, the liver function test results returned to near-normal values. This observation supports the need to monitor cholestatic parameters in addition to liver function enzymes during initiation and the first weeks of risperidone intake.

[1]  R. Andrade,et al.  Drug-induced hepatotoxicity , 2003, The New England journal of medicine.

[2]  F. Benazzi.  Risperidone-induced hepatotoxicity. , 1998, Pharmacopsychiatry.

[3]  F. Baldelli,et al.  Acute Interstitial Nephritis Secondary to the Administration of Indinavir , 1998, The Annals of pharmacotherapy.

[4]  S. Knowles,et al.  Rapid Onset of Risperidone-Induced Hepatotoxicity , 1998, The Annals of pharmacotherapy.

[5]  S. Kumra,et al.  Case study: risperidone-induced hepatotoxicity in pediatric patients. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[6]  M. Fuller,et al.  Risperidone-associated hepatotoxicity. , 1996, Journal of clinical psychopharmacology.

[7]  F Kern,et al.  Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. , 1976, Gastroenterology.