An investigation of the effects on agglomeration of changing the speed of a mechanical mixer

A study that focussed on the effects on agglomeration of changing the rotational speed of a vertical-axis high shear mixer is reported. The design of the mixer was such that, at high impeller speeds, the power input was high. The agglomeration behaviour was found to vary greatly with impeller speed. At low impeller speed, the extent of size enlargement increased with power input. At high impeller speed, the extent of size enlargement was low relative to the large power input. From examination of the changes in size distributions of the granules and of granule morphology, it was concluded that, at high speed, size enlargement was limited by granule breakage. The observation is important as it may provide an improved means of controlling the process.

[1]  Torben Schæfer,et al.  Melt pelletization in a high shear mixer. IX. Effects of binder particle size , 1996 .

[2]  M. Hounslow,et al.  An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration , 1998 .

[3]  Torben Schæfer,et al.  Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity , 1996 .

[4]  P. C. Knight,et al.  An investigation of the kinetics of granulation using a high shear mixer , 1993 .

[5]  T. Schæfer,et al.  Melt pelletization in a high shear mixer. VII. Effects of product temperature , 1996 .

[6]  H. Vromans,et al.  Growth mechanisms of high-shear pelletisation , 1997 .

[7]  Sotiris E. Pratsinis,et al.  Agglomeration behaviour of powders in a Lödige mixer granulator , 1998 .

[8]  P. C. Knight,et al.  An investigation into the effects of binder viscosity on agglomeration behaviour , 1997 .

[9]  T. Schæfer Melt pelletization in a high shear mixer. X. Agglomeration of binary mixtures , 1996 .

[10]  H. Kristensen,et al.  Melt pelletization in a high shear mixer. V. Effects of apparatus variables , 1993 .

[11]  Torben Schæfer,et al.  Effects of binder rheology on melt agglomeration in a high shear mixer , 1998 .

[12]  H. Kristensen,et al.  Particle agglomeration in high shear mixers , 1996 .

[13]  P. Vonk,et al.  Scale-down of a high-shear pelletisation process: flow profile and growth kinetics , 1998 .

[14]  Torben Schæfer,et al.  Melt Granulation in A Laboratory Scale High Shear Mixer , 1990 .

[15]  P. Mort,et al.  Critical parameters and limiting conditions in binder granulation of fine powders , 1997 .

[16]  H. Kristensen,et al.  Growth mechanisms in melt agglomeration with a low viscosity binder. , 1999, International journal of pharmaceutics.

[17]  T. Schæfer Melt pelletization in a high shear mixer VI. Agglomeration of a cohesive powder , 1996 .

[18]  H. Kristensen,et al.  Melt pelletization in a high shear mixer. IV. Effects of process variables in a laboratory scale mixer , 1993 .

[19]  Jpk Seville,et al.  Prediction of impeller torque in high shear powder mixers , 2001 .

[20]  P. C. Kapur Balling and Granulation , 1978 .