Why directionality is an important light factor for human health to consider in lighting design

Both image-forming and non-image-forming effects of radiation require proper attention in lighting design that aims at meeting human vision and health requirements. Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) appear to play an essential role in stimulation of the non-image forming effects and thus human health and well-being. There are indications that radiation incident contributes to the magnitude of these effects. This review summarizes current studies on humans and animals related to radiation directionality as well as the spatial distribution of ipRGCs on the retina. New insights can facilitate and optimize the incorporation of radiation directionality in building lighting design.

[1]  Glen T. Prusky,et al.  Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision , 2010, Neuron.

[2]  D. Berson,et al.  Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock , 2002, Science.

[3]  Anne Germain,et al.  Circadian rhythm disturbances in depression , 2008, Human psychopharmacology.

[4]  Kwoon Y. Wong,et al.  Synaptic influences on rat ganglion‐cell photoreceptors , 2007, The Journal of physiology.

[5]  K. Yau,et al.  Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity , 2002, Science.

[6]  F. Alibhai,et al.  Consequences of Circadian and Sleep Disturbances for the Cardiovascular System. , 2015, The Canadian journal of cardiology.

[7]  S. Daan,et al.  Melatonin Suppression by Light in Humans Is Maximal When the Nasal Part of the Retina Is Illuminated , 1999, Journal of biological rhythms.

[8]  Russell G Foster,et al.  Light‐induced c‐fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice , 2003, The European journal of neuroscience.

[9]  M. Avilés-Trigueros,et al.  Number and spatial distribution of intrinsically photosensitive retinal ganglion cells in the adult albino rat. , 2013, Experimental eye research.

[10]  Philip Weinstein,et al.  Are some melanomas caused by artificial light? , 2010, Medical hypotheses.

[11]  Nicolás Cuenca,et al.  Impairment of intrinsically photosensitive retinal ganglion cells associated with late stages of retinal degeneration. , 2013, Investigative ophthalmology & visual science.

[12]  Nicolás Cuenca,et al.  Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a. , 2015, Investigative ophthalmology & visual science.

[13]  D. Berson,et al.  Melanopsin, Ganglion-Cell Photoreceptors, and Mammalian Photoentrainment , 2003, Journal of biological rhythms.

[14]  Steven Hughes,et al.  Nonuniform Distribution and Spectral Tuning of Photosensitive Retinal Ganglion Cells of the Mouse Retina , 2013, Current Biology.

[15]  Paloma Sobrado-Calvo,et al.  Displaced retinal ganglion cells in albino and pigmented rats , 2014, Front. Neuroanat..

[16]  D F Kripke,et al.  Melatonin Suppression by Illumination of Upper and Lower Visual Fields , 1999, Journal of biological rhythms.

[17]  Paloma Sobrado-Calvo,et al.  Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer. , 2015, Investigative ophthalmology & visual science.

[18]  P. Kofuji,et al.  Diverse types of ganglion cell photoreceptors in the mammalian retina , 2012, Progress in Retinal and Eye Research.

[19]  R. Stevens.  Light-at-night, circadian disruption and breast cancer: assessment of existing evidence. , 2009, International journal of epidemiology.

[20]  Melanie Rüger,et al.  Nasal versus Temporal Illumination of the Human Retina: Effects on Core Body Temperature, Melatonin, and Circadian Phase , 2005, Journal of biological rhythms.

[21]  K. Yau,et al.  Intrinsically photosensitive retinal ganglion cells. , 2010, Physiological reviews.

[22]  Mirjam Münch,et al.  Intrinsically photosensitive retinal ganglion cells: classification, function and clinical implications. , 2013, Current opinion in neurology.

[23]  Z. Yin,et al.  A microRNA, mir133b, suppresses melanopsin expression mediated by failure dopaminergic amacrine cells in RCS rats. , 2012, Cellular signalling.

[24]  C. Jeon,et al.  Localization of melanopsin-immunoreactive cells in the Mongolian gerbil retina , 2015, Neuroscience Research.

[25]  G. Brainard,et al.  Inferior Retinal Light Exposure Is More Effective than Superior Retinal Exposure in Suppressing Melatonin in Humans , 2003, Journal of biological rhythms.

[26]  Ulrike Grünert,et al.  Characterization and synaptic connectivity of melanopsin‐containing ganglion cells in the primate retina , 2007, The European journal of neuroscience.

[27]  L. P. Morin,et al.  Retinal ganglion cell projections to the hamster suprachiasmatic nucleus, intergeniculate leaflet, and visual midbrain: Bifurcation and melanopsin immunoreactivity , 2003, The Journal of comparative neurology.

[28]  J. Pokorny,et al.  Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN , 2005, Nature.

[29]  Carlos Gias,et al.  Retrograde Melanopsin Signaling Increases With Age in Retinal Degenerate Mice Lacking Rods and the Majority of Cones. , 2016, Investigative ophthalmology & visual science.

[30]  M. Vidal-Sanz,et al.  Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats. , 2015, Investigative ophthalmology & visual science.

[31]  Charles A Czeisler,et al.  Melanopsin and Rod–Cone Photoreceptors Play Different Roles in Mediating Pupillary Light Responses during Exposure to Continuous Light in Humans , 2012, The Journal of Neuroscience.

[32]  P. Fuller,et al.  Immunotoxin‐induced ablation of melanopsin retinal ganglion cells in a non‐murine mammalian model , 2009, The Journal of comparative neurology.

[33]  R. Hut,et al.  Immunohistochemical evidence of a melanopsin cone in human retina. , 2006, Investigative ophthalmology & visual science.

[34]  Riccardo Storchi,et al.  Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones. , 2015, Journal of neurophysiology.

[35]  Kwoon Y. Wong,et al.  Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells , 2014, The Journal of physiology.

[36]  J. Hannibal,et al.  The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract , 2002, The Journal of Neuroscience.

[37]  Mbc Myriam Aries,et al.  Implementing non-image-forming effects of light in the built environment: A review on what we need , 2016 .

[38]  Glen Jeffery,et al.  Melanopsin (Opn4) positive cells in the cat retina are randomly distributed across the ganglion cell layer , 2005, Visual Neuroscience.