Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum

Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship.This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens.The relative efficacy of various agonists and antagonists of dopamine receptors have been determined on this test.It appears that this stereotyped behavior might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.

[1]  T. Haley,et al.  Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. , 1957, British journal of pharmacology and chemotherapy.

[2]  H. Lal,et al.  Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol. , 1974, Life sciences.

[3]  U. Ungerstedt,et al.  Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. , 1971, Acta physiologica Scandinavica. Supplementum.

[4]  G. Yarbrough.  Supersensitivity of caudate neurones after repeated administration of haloperidol. , 1975, European journal of pharmacology.

[5]  B. Senault.  Comportement d'agressivité intraspécifique induit par l'apomorphine chez le rat , 1970, Psychopharmacologia.

[6]  L. Iversen,et al.  Stimulation of a dopamine-sensitive adenylate cyclase in homogenates of rat striatum by a metabolite of piribedil (ET 495) , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[7]  K. E. Moore,et al.  A comparison of effects of apomorphine and ET495 on locomotor activity and circling behaviour in mice. , 1974, Neuropharmacology.

[8]  S. Iversen,et al.  Behavioral correlates of dopaminergic supersensitivity. , 1975, Advances in neurology.

[9]  J. Rossum,et al.  Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens , 1973, The Journal of pharmacy and pharmacology.

[10]  N. Uretsky,et al.  Altered response to apomorphine in 6-hydroxydopamine-treated rats. , 1972, European journal of pharmacology.

[11]  P. Vonvoigtlander,et al.  Increased sensitivity to dopaminergic agents after chronic neuroleptic treatment. , 1975, The Journal of pharmacology and experimental therapeutics.

[12]  U. Ungerstedt,et al.  Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. , 1970, Brain research.

[13]  S. Iversen,et al.  Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum , 1975, Brain Research.

[14]  A. M. Ernst,et al.  Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats , 2004, Psychopharmacologia.

[15]  J. Schwartz,et al.  Rapid and dissociated changes in sensitivities of different dopamine receptors in mouse brain , 1975, Nature.

[16]  T. Hökfelt,et al.  Evidence for dopamine receptor stimulation by apomorphine , 1967, The Journal of pharmacy and pharmacology.

[17]  R. Baldessarini,et al.  Pharmacologically induced behavioural supersensitivity to apomorphine. , 1973, Nature: New biology.

[18]  F. Colpaert,et al.  Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA. , 1975, European journal of pharmacology.