The new frontiers of multimodality and multi-isotope imaging

Technological advances in imaging systems and the development of target specific imaging tracers has been rapidly growing over the past two decades. Recent progress in “all-in-one” imaging systems that allow for automated image coregistration has significantly added to the growth of this field. These developments include ultra high resolution PET and SPECT scanners that can be integrated with CT or MR resulting in PET/CT, SPECT/CT, SPECT/PET and PET/MRI scanners for simultaneous high resolution high sensitivity anatomical and functional imaging. These technological developments have also resulted in drastic enhancements in image quality and acquisition time while eliminating cross compatibility issues between modalities. Furthermore, the most cutting edge technology, though mostly preclinical, also allows for simultaneous multimodality multi-isotope image acquisition and image reconstruction based on radioisotope decay characteristics. These scientific advances, in conjunction with the explosion in the development of highly specific multimodality molecular imaging agents, may aid in realizing simultaneous imaging of multiple biological processes and pave the way towards more efficient diagnosis and improved patient care.

[1]  Torsten Kuwert,et al.  SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  Yeong Su Ha,et al.  Facile preparation of a hybrid nanoprobe for triple-modality optical/PET/MR imaging. , 2010, Small.

[3]  F. Beekman,et al.  U-SPECT-II: An Ultra-High-Resolution Device for Molecular Small-Animal Imaging , 2009, Journal of Nuclear Medicine.

[4]  Suleman Surti,et al.  Experimental evaluation of a simple lesion detection task with time-of-flight PET , 2009, Physics in medicine and biology.

[5]  S. L. Bridal,et al.  Perfluorooctyl Bromide Polymeric Capsules as Dual Contrast Agents for Ultrasonography and Magnetic Resonance Imaging , 2008 .

[6]  D Artemov,et al.  Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA , 2009, Cancer Gene Therapy.

[7]  Jean-Claude Liehn,et al.  The growing development of multimodality imaging in oncology. , 2008, Critical reviews in oncology/hematology.

[8]  S. Cherry,et al.  Assessment of artifacts in simultaneous PET and MR imaging , 1997, 1997 IEEE Nuclear Science Symposium Conference Record.

[9]  G. Delso,et al.  Performance Measurements of the Siemens mMR Integrated Whole-Body PET/MR Scanner , 2011, The Journal of Nuclear Medicine.

[10]  R. Danieli,et al.  Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation? , 2004, Nuclear medicine communications.

[11]  Baris Turkbey,et al.  Review of functional/anatomical imaging in oncology , 2012, Nuclear medicine communications.

[12]  Koichiro Abe,et al.  Benefits of Point-Spread Function and Time of Flight for PET/CT Image Quality in Relation to the Body Mass Index and Injected Dose , 2013, Clinical nuclear medicine.

[13]  W. Lu,et al.  Annexin A5–Conjugated Polymeric Micelles for Dual SPECT and Optical Detection of Apoptosis , 2011, The Journal of Nuclear Medicine.

[14]  Gerald Antoch,et al.  Combined PET/MRI: a new dimension in whole-body oncology imaging? , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[15]  V. Bettinardi,et al.  Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[16]  Dale L Bailey,et al.  SPECT/CT imaging using a spiral CT scanner for anatomical localization: Impact on diagnostic accuracy and reporter confidence in clinical practice , 2006, Nuclear medicine communications.

[17]  M. Dahlbom,et al.  The Road to Simultaneous PET/MR Images of the Brain , 1998 .

[18]  Sanjiv S. Gambhir,et al.  Dual-Function Probe for PET and Near-Infrared Fluorescence Imaging of Tumor Vasculature , 2007, Journal of Nuclear Medicine.

[19]  T. Budinger.  Time-of-flight positron emission tomography: status relative to conventional PET. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  Fan Zhang,et al.  Chimeric ferritin nanocages for multiple function loading and multimodal imaging. , 2011, Nano letters.

[21]  Munawwar Sajjad,et al.  Multimodality agents for tumor imaging (PET, fluorescence) and photodynamic therapy. A possible "see and treat" approach. , 2005, Journal of medicinal chemistry.

[22]  M. Pomper,et al.  Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen. , 2011, Angewandte Chemie.

[23]  J. Karp,et al.  Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[24]  S. Cherry,et al.  A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner. , 1999, Physics in medicine and biology.

[25]  Chenjie Xu,et al.  PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)–Conjugated Radiolabeled Iron Oxide Nanoparticles , 2008, Journal of Nuclear Medicine.

[26]  S. Gambhir,et al.  Molecular imaging in living subjects: seeing fundamental biological processes in a new light. , 2003, Genes & development.

[27]  P. E. B. Vaissier,et al.  Fast Spiral SPECT with Stationary γ-Cameras and Focusing Pinholes , 2012, The Journal of Nuclear Medicine.

[28]  A Celler,et al.  Dual-isotope PET using positron-gamma emitters , 2011, Physics in medicine and biology.

[29]  D. Mankoff,et al.  Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study , 2011, The Journal of Nuclear Medicine.

[30]  J. Karp,et al.  Implementation and Evaluation of a 3D PET Single Scatter Simulation with TOF Modeling , 2006, 2006 IEEE Nuclear Science Symposium Conference Record.

[31]  S. Cherry,et al.  Simultaneous PET and MR imaging , 1997, Physics in medicine and biology.

[32]  D. Meier,et al.  Development and evaluation of a dual-modality (MRI/SPECT) molecular imaging bioprobe. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[33]  B. Sharma,et al.  PET/CT in oncology--a major advance. , 2005, Clinical radiology.

[34]  H. Zaidi,et al.  Design and performance evaluation of a whole-body Ingenuity TF PET–MRI system , 2011, Physics in medicine and biology.

[35]  David A. Jaffray,et al.  In Vivo Performance of a Liposomal Vascular Contrast Agent for CT and MR-Based Image Guidance Applications , 2007, Pharmaceutical Research.

[36]  Sung Ho Ryu,et al.  A Nucleolin-Targeted Multimodal Nanoparticle Imaging Probe for Tracking Cancer Cells Using an Aptamer , 2010, Journal of Nuclear Medicine.

[37]  Maurizio Conti,et al.  Experimental comparison of lesion detectability for four fully-3D PET reconstruction schemes , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[38]  J. Karp,et al.  Improvement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET , 2011, The Journal of Nuclear Medicine.

[39]  Brendan Vastenhouw,et al.  VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET , 2013, The Journal of Nuclear Medicine.