SIRT 1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase *

Xiuyun Hou, Shanqin Xu, Karlene A. Maitland-Toolan, Kaori Sato, Bingbing Jiang, Yasuo Ido, Fan Lan, Kenneth Walsh, Michel Wierzbicki , Tony J. Verbeuren , Richard A. Cohen, and Mengwei Zang From the Vascular Biology Unit and Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, and Section of Endocrinology, Boston University, Boston, Massachusetts 02118 and Institut de Recherche Servier, Suresnes 92150, France