Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.
暂无分享,去创建一个
Feixiong Cheng | Yun Tang | Zhejun Xu | Guixia Liu | F. Cheng | Guixia Liu | Yun Tang | Zhejun Xu
[1] K. Jacobson,et al. Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis. , 1992, The Journal of biological chemistry.
[2] M. Loza,et al. 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships. , 2008, Bioorganic & medicinal chemistry.
[3] J. Thornton,et al. Stereochemical quality of protein structure coordinates , 1992, Proteins.
[4] Ruben Abagyan,et al. Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. , 2010, Journal of medicinal chemistry.
[5] John B. Shoven,et al. I , Edinburgh Medical and Surgical Journal.
[6] A. Knight,et al. Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. , 2009, Journal of medicinal chemistry.
[7] K. Jacobson,et al. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. , 2000, Journal of medicinal chemistry.
[8] Richard M. Jackson,et al. An evaluation of automated homology modelling methods at low target-template sequence similarity , 2007, Bioinform..
[9] K. Palczewski,et al. Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.
[10] K. Klotz,et al. A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. , 2006, Journal of medicinal chemistry.
[11] J. Shine,et al. Molecular cloning and expression of an adenosine A2b receptor from human brain. , 1992, Biochemical and biophysical research communications.
[12] G. G. Stokes. "J." , 1890, The New Yale Book of Quotations.
[13] I. Biaggioni,et al. Adenosine-Activated Mast Cells Induce IgE Synthesis by B Lymphocytes: An A2B-Mediated Process Involving Th2 Cytokines IL-4 and IL-13 with Implications for Asthma12 , 2004, The Journal of Immunology.
[14] Bartosz Trzaskowski,et al. Predicted 3D structures for adenosine receptors bound to ligands: comparison to the crystal structure. , 2010, Journal of structural biology.
[15] Luhua Lai,et al. Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. , 2008, Journal of medicinal chemistry.
[16] Xiaofen Li,et al. Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines. , 2008, Bioorganic & medicinal chemistry letters.
[17] B. Fredholm,et al. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. , 2001, Pharmacological reviews.
[18] J. Wess,et al. Site-directed Mutagenesis Identifies Residues Involved in Ligand Recognition in the Human A2a Adenosine Receptor (*) , 1995, The Journal of Biological Chemistry.
[19] S. Holgate,et al. Adenosine A2B receptors: a novel therapeutic target in asthma? , 1998, Trends in pharmacological sciences.
[20] K. Jacobson,et al. Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. , 2001, Journal of medicinal chemistry.
[21] Martin S. Fridson,et al. Trends , 1948, Bankmagazin.
[22] J. Thompson,et al. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.
[23] K. Jacobson,et al. Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor* , 2002, The Journal of Biological Chemistry.
[24] K. Klotz,et al. 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. , 2009, Bioorganic & medicinal chemistry.
[25] R. Stevens,et al. The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist , 2008, Science.
[26] Ravi Shashi Nayana,et al. Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. , 2009, Bioorganic & medicinal chemistry.
[27] G Burnstock,et al. Receptors for purines and pyrimidines. , 1998, Pharmacological reviews.
[28] Patrick Scheerer,et al. Crystal structure of the ligand-free G-protein-coupled receptor opsin , 2008, Nature.
[29] David A. Lustig,et al. Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. , 2008, Journal of medicinal chemistry.
[30] Farag F. Sherbiny,et al. Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the β2-adrenergic receptor and the human adenosine A2A receptor , 2009, J. Comput. Aided Mol. Des..
[31] S. Rivkees,et al. Identification of the Adenine Binding Site of the Human A1 Adenosine Receptor* , 1999, The Journal of Biological Chemistry.
[32] David M. Ferguson,et al. A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist , 2006, J. Comput. Aided Mol. Des..
[33] I Biaggioni,et al. Adenosine A2B receptors. , 1997, Pharmacological reviews.
[34] K. Varani,et al. Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. , 2004, Journal of medicinal chemistry.
[35] Jing Wei,et al. 3D-Pharmacophore Models for Selective A2A and A2B Adenosine Receptor Antagonists , 2007, J. Chem. Inf. Model..
[36] A. IJzerman,et al. Structure‐affinity relationships of adenosine A2B receptor ligands , 2006, Medicinal research reviews.
[37] A. Pramod,et al. Quantitative Structure Activity Relationship and Pharmacophore Studies of Adenosine Receptor A2B Inhibitors , 2008, Chemical biology & drug design.
[38] T. Schwartz,et al. A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. , 2008, Biochemistry.
[39] Miss A.O. Penney. (b) , 1974, The New Yale Book of Quotations.
[40] J. Wess,et al. Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition. , 1996, Molecular pharmacology.
[41] S. Rasmussen,et al. The structure and function of G-protein-coupled receptors , 2009, Nature.
[42] Rao Kalla,et al. Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. , 2006 .
[43] I. Biaggioni,et al. Hypoxia Modulates Adenosine Receptors in Human Endothelial and Smooth Muscle Cells Toward an A2B Angiogenic Phenotype , 2004, Hypertension.
[44] M. Burghammer,et al. Crystal structure of the human β2 adrenergic G-protein-coupled receptor , 2007, Nature.
[45] A. Ivanov,et al. Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists. , 2005, Journal of Medicinal Chemistry.
[46] Gebhard F. X. Schertler,et al. Structure of a β1-adrenergic G-protein-coupled receptor , 2008, Nature.
[47] X. García‐Mera,et al. Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists. , 2010, European journal of medicinal chemistry.
[48] C. Ledent,et al. Cardioprotection by Ecto-5′-Nucleotidase (CD73) and A2B Adenosine Receptors , 2007, Circulation.
[49] A. Tucker,et al. A1 adenosine receptors. Two amino acids are responsible for species differences in ligand recognition. , 1994, The Journal of biological chemistry.
[50] A. Castelhano,et al. [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. , 2004, Biochemical pharmacology.
[51] I. Biaggioni,et al. A2B Adenosine Receptors Increase Cytokine Release by Bronchial Smooth Muscle Cells , 2004 .
[52] K. Jacobson,et al. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. , 2003, Bioorganic & medicinal chemistry.
[53] K. Jacobson,et al. Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. , 2002, Journal of medicinal chemistry.
[54] J. Linden,et al. Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. , 1997, Molecular pharmacology.