MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.

[1]  Y. Payette,et al.  Mixed Lymphocyte Reaction (MLR) , 2021, Manual of Immunological Methods.

[2]  Ramnik J. Xavier,et al.  T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation , 2018, Cell.

[3]  Oliver S. Thomas,et al.  Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. , 2018, Blood.

[4]  Jason S. Mitchell,et al.  T Cells in Nonlymphoid Tissues Give Rise to Lymph‐Node‐Resident Memory T Cells , 2018, Immunity.

[5]  W. Wood,et al.  The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future. , 2018, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[6]  J. P. Martins,et al.  Flt-3L Expansion of Recipient CD8α+ Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD , 2018, Clinical Cancer Research.

[7]  H. Jim,et al.  In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation , 2017, Haematologica.

[8]  Tetsuya Hayashi,et al.  R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease , 2017, The Journal of experimental medicine.

[9]  B. Blazar,et al.  Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy. , 2017, The New England journal of medicine.

[10]  C. Leslie,et al.  ILC1 Confer Early Host Protection at Initial Sites of Viral Infection , 2017, Cell.

[11]  P. Hugenholtz,et al.  Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. , 2017, Blood.

[12]  S. McColl,et al.  Eomesodermin promotes the development of type 1 regulatory T (TR1) cells , 2017, Science Immunology.

[13]  G. Hill,et al.  Alloantigen presentation and graft-versus-host disease: fuel for the fire. , 2016, Blood.

[14]  Tommi Vatanen,et al.  Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans , 2016, Cell.

[15]  Y. Taur,et al.  Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice , 2016, Science Translational Medicine.

[16]  E. Unanue,et al.  Variations in MHC Class II Antigen Processing and Presentation in Health and Disease. , 2016, Annual review of immunology.

[17]  Eric A. Franzosa,et al.  Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans , 2016, Cell.

[18]  Corinne Rossi,et al.  Gut microbiome derived metabolites modulate intestinal epithelial cell damage and mitigate Graft-versus-Host Disease , 2016, Nature Immunology.

[19]  S. McColl,et al.  Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease , 2015, The Journal of experimental medicine.

[20]  G. Hill,et al.  Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. , 2015, Blood.

[21]  C. Biron,et al.  Immunoregulatory cytokine networks: 60 years of learning from murine cytomegalovirus , 2015, Medical Microbiology and Immunology.

[22]  P. Roche,et al.  The ins and outs of MHC class II-mediated antigen processing and presentation , 2015, Nature Reviews Immunology.

[23]  N. Cloonan,et al.  Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. , 2014, The Lancet. Oncology.

[24]  Taku Kambayashi,et al.  Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell? , 2014, Nature Reviews Immunology.

[25]  W. Reith,et al.  Interferon-γ Induces Expression of MHC Class II on Intestinal Epithelial Cells and Protects Mice from Colitis , 2014, PloS one.

[26]  R. Medzhitov,et al.  The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition , 2014, Proceedings of the National Academy of Sciences.

[27]  Hiroyuki Miyoshi,et al.  In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture , 2013, Nature Protocols.

[28]  Bihui Huang,et al.  Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals , 2013, Science.

[29]  A. Kaser,et al.  Paneth cells as a site of origin for intestinal inflammation , 2013, Nature.

[30]  J. Falkenburg,et al.  HLA class II upregulation during viral infection leads to HLA-DP-directed graft-versus-host disease after CD4+ donor lymphocyte infusion. , 2013, Blood.

[31]  Kristin Stephens,et al.  Vedolizumab as induction and maintenance therapy for Crohn's disease. , 2013, The New England journal of medicine.

[32]  J. Doré,et al.  Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice , 2012, Mucosal Immunology.

[33]  R. Khanin,et al.  Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation , 2012, The Journal of experimental medicine.

[34]  R. Korngold,et al.  Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells. , 2012, Blood.

[35]  J. McNiff,et al.  Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction , 2012, The Journal of Immunology.

[36]  B. Malissen,et al.  Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease , 2011, Nature Medicine.

[37]  F. Ginhoux,et al.  Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation , 2011, The Journal of experimental medicine.

[38]  Marcel Martin.  Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .

[39]  M. Veldhoen,et al.  Fate mapping of interleukin 17-producing T cells in inflammatory responses , 2011, Nature Immunology.

[40]  D. Jain,et al.  Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells , 2011, The Journal of Immunology.

[41]  D. Hume,et al.  An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. , 2010, Blood.

[42]  Mark D. Robinson,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[43]  A. Velcich,et al.  The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria , 2008, Proceedings of the National Academy of Sciences.

[44]  F. Appelbaum,et al.  Blood and Marrow Transplant Clinical Trials Network State of the Science Symposium 2007. , 2007, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[45]  S. McColl,et al.  IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. , 2007, Blood.

[46]  P. Adegboyega,et al.  Subepithelial Myofibroblasts are Novel Nonprofessional APCs in the Human Colonic Mucosa1 , 2006, The Journal of Immunology.

[47]  T. Banović,et al.  Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation. , 2006, Blood.

[48]  C. Contag,et al.  In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. , 2005, Blood.

[49]  T. Tuschl,et al.  Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy , 2005, Science.

[50]  Daniel Metzger,et al.  Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium , 2004, Genesis.

[51]  S. Akira,et al.  Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway , 2003, Science.

[52]  Jan Cerny,et al.  T-cell engagement of dendritic cells rapidly rearranges MHC class II transport , 2002, Nature.

[53]  M. Anver,et al.  Administration of either anti-CD40 or interleukin-12 following lethal total body irradiation induces acute lethal toxicity affecting the gut. , 2002, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[54]  J. Ferrara,et al.  Acute graft-versus-host disease does not require alloantigen expression on host epithelium , 2002, Nature Medicine.

[55]  K. Hashimoto,et al.  A conditional null allele of the major histocompatibility IA‐beta chain gene , 2002, Genesis.

[56]  Shankar Srinivas,et al.  Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus , 2001, BMC Developmental Biology.

[57]  O. Lantz,et al.  γ chain required for naïve CD4+ T cell survival but not for antigen proliferation , 2000, Nature Immunology.

[58]  G. Hill,et al.  The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. , 2000, Blood.

[59]  M. Shlomchik,et al.  Prevention of graft versus host disease by inactivation of host antigen-presenting cells. , 1999, Science.

[60]  A. Elmaagacli,et al.  Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and long-term follow-up of an open-label prospect , 1999, Blood.

[61]  J. Crawford,et al.  An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. , 1996, Blood.

[62]  MJ Grusby,et al.  Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice , 1991, Science.

[63]  D. Jewell,et al.  Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon. , 1987, Journal of clinical pathology.

[64]  P. Russell,et al.  Widespread and selective induction of major histocompatibility complex- determined antigens in vivo by gamma interferon , 1985, The Journal of experimental medicine.

[65]  J. Lamb,et al.  Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells , 1984, Nature.

[66]  E. Holler,et al.  Graft-versus-host disease , 2009, The Lancet.

[67]  P. Rutgeerts,et al.  Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease. , 2016, The New England journal of medicine.

[68]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[69]  J. Hermans,et al.  Prevention of infection and graft-versus-host disease by suppression of intestinal microflora in children treated with allogeneic bone marrow transplantation , 2005, European Journal of Clinical Microbiology and Infectious Diseases.