Biological complexity, quantum coherent states and the problem of efficient transmission of information inside a cell

The intracellular channel of information transmission was analyzed from the point of view of complexity. The most important steps in the transfer of information within a cell are the folding, transport and recognition of proteins. It was shown that the large number of conformational degrees of freedom that proteins possess can paradoxically lead to an information channel with an exponentially small capacity. To resolve this paradox, a model, which assumes a quantum collective behavior of biologically important molecules, was proposed. Experiments to test the quantum nature of the intracellular transfer of information were also proposed.

[1]  Jack A Tuszynski,et al.  Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression. , 2012, AIP advances.

[2]  István Simon,et al.  The expanding view of protein–protein interactions: complexes involving intrinsically disordered proteins , 2011, Physical biology.

[3]  D. Sherrington Stochastic Processes in Physics and Chemistry , 1983 .

[4]  Koichiro Matsuno,et al.  Forming and maintaining a heat engine for quantum biology. , 2006, Bio Systems.

[5]  V. D. Seleznev,et al.  Model of active transport of ions in biomembranes based on ATP-dependent change of height of diffusion barriers to ions. , 2006, Journal of theoretical biology.

[6]  D. Bray Protein molecules as computational elements in living cells , 1995, Nature.

[7]  V. D. Seleznev,et al.  Mechanisms and models of the active transport of ions and the transformation of energy in intracellular compartments. , 2012, Progress in biophysics and molecular biology.

[8]  P. Steinhardt Solid-state physics: How does your quasicrystal grow? , 2008, Nature.

[9]  Koichiro Matsuno Chemical evolution as a concrete scheme for naturalizing the relative-state of quantum mechanics , 2012, Biosyst..

[10]  V. D. Seleznev,et al.  Requirements on Models and Models of Active Transport of Ions in Biomembranes , 2006, Bulletin of mathematical biology.

[11]  E. Lucero,et al.  Reversal of the weak measurement of a quantum state in a superconducting phase qubit. , 2008, Physical review letters.

[12]  Jack Tuszynski,et al.  Conduction pathways in microtubules, biological quantum computation, and consciousness. , 2002, Bio Systems.

[13]  Vaidman,et al.  How the result of a measurement of a component of the spin of a spin-1/2 particle can turn out to be 100. , 1988, Physical review letters.

[14]  M. Karplus,et al.  How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations , 2004, Science.

[15]  S. Carroll,et al.  Evolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins , 2003, Science.

[16]  Igor N Berezovsky,et al.  Loop Fold Structure of Proteins: Resolution of Levinthal's Paradox , 2002, Journal of biomolecular structure & dynamics.

[17]  A U Igamberdiev,et al.  Foundations of metabolic organization: coherence as a basis of computational properties in metabolic networks. , 1999, Bio Systems.

[18]  Abir U Igamberdiev,et al.  Quantum computation, non-demolition measurements, and reflective control in living systems. , 2004, Bio Systems.

[19]  A. Melkikh,et al.  Developing Synthetic Transport Systems , 2013, Springer Netherlands.

[20]  D. Deutsch The fabric of reality , 1997, The Art of Political Storytelling.

[21]  J. Eccles,et al.  Quantum aspects of brain activity and the role of consciousness. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[22]  J. McFadden,et al.  A quantum mechanical model of adaptive mutation. , 1999, Bio Systems.

[23]  Yawen Bai Energy barriers, cooperativity, and hidden intermediates in the folding of small proteins. , 2006, Biochemical and biophysical research communications.

[24]  T. Misteli Beyond the Sequence: Cellular Organization of Genome Function , 2011 .

[25]  A. Goswami,et al.  Is there conscious choice in directed mutation, phenocopies, and related phenomena? An answer based on quantum measurement theory , 1997, Integrative physiological and behavioral science : the official journal of the Pavlovian Society.

[26]  P. Davies,et al.  Does quantum mechanics play a non-trivial role in life? , 2004, Bio Systems.

[27]  Peter Dittrich,et al.  Cells as semantic systems. , 2011, Biochimica et biophysica acta.

[28]  Nan Yao,et al.  Natural Quasicrystals , 2009, Science.

[29]  R. Paton,et al.  Is there a biology of quantum information? , 2000, Bio Systems.

[30]  N. Kampen,et al.  Stochastic processes in physics and chemistry , 1981 .

[31]  Yawen Bai Hidden intermediates and levinthal paradox in the folding of small proteins. , 2003, Biochemical and biophysical research communications.

[32]  V. Ogryzko,et al.  A quantum-theoretical approach to the phenomenon of directed mutations in bacteria (hypothesis). , 1997, Bio Systems.

[33]  Enrique Maciá,et al.  The role of aperiodic order in science and technology , 2006 .

[34]  A. Whitaker The Fabric of Reality , 2001 .

[35]  R. Zwanzig,et al.  Levinthal's paradox. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Andrey G. Cherstvy Electrostatic interactions in biological DNA-related systems. , 2011, Physical chemistry chemical physics : PCCP.

[37]  Apoorva Patel,et al.  Why genetic information processing could have a quantum basis , 2001, Journal of Biosciences.

[38]  E. Klipp,et al.  Information theory based approaches to cellular signaling. , 2011, Biochimica et biophysica acta.

[39]  Geoff S Baldwin,et al.  DNA double helices recognize mutual sequence homology in a protein free environment. , 2008, The journal of physical chemistry. B.

[40]  W. Ebeling Stochastic Processes in Physics and Chemistry , 1995 .

[41]  Alexander Y. Grosberg,et al.  Giant Molecules: Here, There, and Everywhere , 1997 .