Elevated Serotonin Transporter Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]DASB; Comparison with Bipolar Disorder

[1]  S. Ramamoorthy,et al.  Regulation of monoamine transporters: Influence of psychostimulants and therapeutic antidepressants , 2005, The AAPS Journal.

[2]  Cristina Colombo,et al.  Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. , 2007, The international journal of neuropsychopharmacology.

[3]  David Goldman,et al.  Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. , 2007, Archives of general psychiatry.

[4]  Sylvain Houle,et al.  Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. , 2006, Archives of general psychiatry.

[5]  Enrico Smeraldi,et al.  Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants , 2006, Psychiatric genetics.

[6]  Masanori Ichise,et al.  Serotonin Transporter Binding in Bipolar Disorder Assessed using [11C]DASB and Positron Emission Tomography , 2006, Biological Psychiatry.

[7]  R. Buchert,et al.  Inhibition of serotonin transport by (+)McN5652 is noncompetitive. , 2006, Nuclear medicine and biology.

[8]  M. Brandão,et al.  Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive behavior and fear-induced analgesia , 2006, Experimental Neurology.

[9]  R Todd Ogden,et al.  Lower serotonin transporter binding potential in the human brain during major depressive episodes. , 2006, The American journal of psychiatry.

[10]  Sylvain Houle,et al.  Effects of Tryptophan Depletion on the Serotonin Transporter in Healthy Humans , 2005, Biological Psychiatry.

[11]  E. Nielsen,et al.  Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter , 2005, Psychopharmacology.

[12]  A. Alavi,et al.  123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  F. Holsboer,et al.  Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression‐like behaviour: effects of chronic paroxetine treatment , 2005, Journal of neurochemistry.

[14]  Mark Slifstein,et al.  Effects of reduced endogenous 5‐HT on the in vivo binding of the serotonin transporter radioligand 11C‐DASB in healthy humans , 2005, Synapse.

[15]  Bengt Långström,et al.  Potential of [11C]DASB for measuring endogenous serotonin with PET: binding studies. , 2005, Nuclear medicine and biology.

[16]  P. Riederer,et al.  Organization of the human serotonin transporter gene , 2005, Journal of Neural Transmission / General Section JNT.

[17]  Sylvain Houle,et al.  Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. , 2004, Archives of general psychiatry.

[18]  J. Amsterdam,et al.  PET brain imaging with [11C](+)McN5652 shows increased serotonin transporter availability in major depression. , 2004, Journal of affective disorders.

[19]  R Plomin,et al.  Gene–environment interaction analysis of serotonin system markers with adolescent depression , 2004, Molecular Psychiatry.

[20]  A. Heinz,et al.  DASB –in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer , 2004, Journal of neurochemistry.

[21]  C. Halldin,et al.  Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain , 2004, Human brain mapping.

[22]  D. Weinberger,et al.  Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates. , 2004, Journal of neural transmission. Supplementum.

[23]  R. Baldessarini,et al.  Antidepressant treatment in bipolar versus unipolar depression. , 2004, The American journal of psychiatry.

[24]  V. Klimek,et al.  Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression. , 2003, Journal of psychiatric research.

[25]  C. Stockmeier.  Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. , 2003, Journal of psychiatric research.

[26]  Jeih-San Liow,et al.  Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[27]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[28]  S. Stahl.  Antidepressants and somatic symptoms: therapeutic actions are expanding beyond affective spectrum disorders to functional somatic syndromes. , 2003, The Journal of clinical psychiatry.

[29]  J. Price,et al.  Architectonic subdivision of the human orbital and medial prefrontal cortex , 2003, The Journal of comparative neurology.

[30]  G. Debonnel,et al.  Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study , 2003, Journal of neurochemistry.

[31]  R. Hu.  Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) , 2003 .

[32]  Alan A. Wilson,et al.  Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  Sylvain Houle,et al.  In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography. , 2002, Nuclear medicine and biology.

[34]  F. Yasuno,et al.  Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652 , 2002, Biological Psychiatry.

[35]  Thomas E. Nichols,et al.  Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate , 2002, NeuroImage.

[36]  Victoria Arango,et al.  Serotonin 1A Receptors, Serotonin Transporter Binding and Serotonin Transporter mRNA Expression in the Brainstem of Depressed Suicide Victims , 2001, Neuropsychopharmacology.

[37]  Alan A. Wilson,et al.  Positron Emission Tomography Quantification of [11C]-DASB Binding to the Human Serotonin Transporter: Modeling Strategies , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  R. Yolken,et al.  Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder , 2001, British Journal of Psychiatry.

[39]  Stephen M. Smith,et al.  A global optimisation method for robust affine registration of brain images , 2001, Medical Image Anal..

[40]  W. Drevets.  Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders , 2001, Current Opinion in Neurobiology.

[41]  S. Houle,et al.  Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography: Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of (11)C-Labeled 2-(Phenylthio)araalkylamines. , 2000, Journal of medicinal chemistry.

[42]  Elizabeth Gould,et al.  Regulation of hippocampal neurogenesis in adulthood , 2000, Biological Psychiatry.

[43]  W. Drevets.  Neuroimaging studies of mood disorders , 2000, Biological Psychiatry.

[44]  Alan A. Wilson,et al.  Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB , 2000, European Journal of Nuclear Medicine.

[45]  B. Vollmayr,et al.  Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in other raphe nuclei of the rat , 2000, Neuroscience Letters.

[46]  L. Friedman,et al.  The serotonin transporter in the midbrain of suicide victims with major depression , 2000, Biological Psychiatry.

[47]  A Frazer,et al.  Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level , 1999, The Journal of Neuroscience.

[48]  Linda Carpenter,et al.  Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography , 1998, Biological Psychiatry.

[49]  A. Becker,et al.  Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat , 1998, Journal of neuroscience research.

[50]  R. Blakely,et al.  Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins , 1998, Biological Psychiatry.

[51]  B. Sabel,et al.  Influence of olfactory bulbectomy and subsequent imipramine treatment on 5‐hydroxytryptaminergic presynapses in the rat frontal cortex: behavioural correlates , 1997, British journal of pharmacology.

[52]  N. Craddock,et al.  Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT) , 1997, Molecular Psychiatry.

[53]  R. Murray,et al.  A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. , 1996, Molecular psychiatry.

[54]  Karl J. Friston,et al.  Detecting Activations in PET and fMRI: Levels of Inference and Power , 1996, NeuroImage.

[55]  Karl J. Friston,et al.  Estimating Smoothness in Statistical Parametric Maps: Variability of p Values , 1995, Journal of computer assisted tomography.

[56]  Zsolt Szabo,et al.  Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)McN5652 , 1995, Synapse.

[57]  F. Bloom,et al.  Psychopharmacology: The Fourth Generation of Progress , 1995 .

[58]  Takeshi Inoue,et al.  Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain , 1994, Pharmacology Biochemistry and Behavior.

[59]  Marc Laruelle,et al.  Methyl 3β‐(4‐[125I]Iodophenyl)Tropane‐2β‐Carboxylate In Vitro Binding to Dopamine and Serotonin Transporters Under “Physiological” Conditions , 1994 .

[60]  H. Ågren,et al.  PET studies of presynaptic monoamine metabolism in depressed patients and healthy volunteers. , 1994, Pharmacopsychiatry.

[61]  J. Mazziotta,et al.  Rapid Automated Algorithm for Aligning and Reslicing PET Images , 1992, Journal of computer assisted tomography.

[62]  B. Jacobs,et al.  Structure and function of the brain serotonin system. , 1992, Physiological reviews.

[63]  I. Ferrier,et al.  Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: Neurochemical and clinical correlates , 1991, Psychiatry Research.

[64]  J. Allman,et al.  Mapping human visual cortex with positron emission tomography , 1986, Nature.

[65]  R. Vertes.  A lectin horseradish peroxidase study of the origin of ascending fibers in the medial forebrain bundle of the rat. The lower brainstem , 1984, Neuroscience.

[66]  M. Åsberg,et al.  CSF monoamine metabolites, depression, and suicide. , 1984, Advances in biochemical psychopharmacology.

[67]  M. Åsberg,et al.  A New Depression Scale Designed to be Sensitive to Change , 1979, British Journal of Psychiatry.

[68]  M. Hamilton.  The assessment of anxiety states by rating. , 1959, The British journal of medical psychology.

[69]  P. Bailey,et al.  Effects of Lesions of the Periaqueductal Gray Matter in the Cat∗ , 1942 .