Inhaled allergen‐driven CD1c up‐regulation and enhanced antigen uptake by activated human respiratory‐tract dendritic cells in atopic asthma

Background Dendritic cells (DC) mediate inflammation in rodent models of allergic airway disease, but the role played by human respiratory‐tract DC (hRTDC) in atopic asthma remains poorly defined. Recent data suggest that CD1 antigen presentation by hRTDC may contribute to asthma pathogenesis.

[1]  A. B. Kay,et al.  Natural killer T cells and asthma. , 2006, The New England journal of medicine.

[2]  G. Berry,et al.  CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. , 2006, The New England journal of medicine.

[3]  S. Ju,et al.  A Major Lung CD103 (αE)-β7 Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins1 , 2006, The Journal of Immunology.

[4]  R. Mannucci,et al.  Human CD1-restricted T cell recognition of lipids from pollens , 2005, The Journal of experimental medicine.

[5]  A. Tonevitsky,et al.  Bacterial infections promote T cell recognition of self-glycolipids. , 2005, Immunity.

[6]  M. Willart,et al.  In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma , 2005, The Journal of experimental medicine.

[7]  R. Pauwels,et al.  Identification and characterization of human pulmonary dendritic cells. , 2005, American journal of respiratory cell and molecular biology.

[8]  B. Lambrecht.  Dendritic cells and the regulation of the allergic immune response , 2005, Allergy.

[9]  Martin J. Mueller,et al.  Abbreviations used: Bet.-APE, , 2022 .

[10]  F. Poccia,et al.  Reciprocal Activating Interaction Between Dendritic Cells and Pamidronate-Stimulated γδ T Cells: Role of CD86 and Inflammatory Cytokines1 , 2005, The Journal of Immunology.

[11]  K. Swanson,et al.  Flt3-Ligand, IL-4, GM-CSF, and Adherence-Mediated Isolation of Murine Lung Dendritic Cells: Assessment of Isolation Technique on Phenotype and Function1 , 2004, The Journal of Immunology.

[12]  H. Hammad,et al.  Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen , 2004, The Journal of experimental medicine.

[13]  J. Belisle,et al.  Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. , 2004, The Journal of clinical investigation.

[14]  P. Sly,et al.  Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma , 2003, Journal of Experimental Medicine.

[15]  R. Pauwels,et al.  Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma. , 2003, American journal of respiratory cell and molecular biology.

[16]  M. Brenner,et al.  CD1-mediated γ/δ T Cell Maturation of Dendritic Cells , 2002, The Journal of experimental medicine.

[17]  E. Grant,et al.  CD1-dependent dendritic cell instruction , 2002, Nature Immunology.

[18]  P. Sterk,et al.  Sputum induction , 2002, European Respiratory Journal.

[19]  M. Weatherall,et al.  An inverse correlation between estimated tuberculosis notification rates and asthma symptoms , 2002, Respirology.

[20]  E. Bonmassar,et al.  Influence of Mycobacterium bovis Bacillus Calmette Guérin on In Vitro Induction of CD1 Molecules in Human Adherent Mononuclear Cells , 2002, Infection and Immunity.

[21]  A. Hamzaoui,et al.  T cells expressing the gammadelta receptor are essential for Th2-mediated inflammation in patients with acute exacerbation of asthma. , 2002, Mediators of inflammation.

[22]  R. Coffman,et al.  A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. , 2002, Immunity.

[23]  N. Alexis,et al.  Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique. , 2001, American journal of respiratory and critical care medicine.

[24]  P. Holt,et al.  Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge , 2001, Thorax.

[25]  D. Umetsu,et al.  Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen , 2001, Nature Immunology.

[26]  P. Thomas.  Tumour necrosis factor‐α: The role of this multifunctional cytokine in asthma , 2001 .

[27]  S. Miltenyi,et al.  BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood , 2000, The Journal of Immunology.

[28]  G. Besra,et al.  CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection , 2000, Nature.

[29]  E. Gelfand,et al.  Negative regulation of airway responsiveness that is dependent on γδ T cells and independent of αβ T cells , 1999, Nature Medicine.

[30]  N. Pearce,et al.  How much asthma is really attributable to atopy? , 1999, Thorax.

[31]  M. Kronenberg,et al.  Presentation of peptide antigens by mouse CD1 requires endosomal localization and protein antigen processing. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[32]  D. Hart,et al.  Dendritic cells: unique leukocyte populations which control the primary immune response. , 1997, Blood.

[33]  H. Hoogsteden,et al.  CD1a+ and CD1a- accessory cells from human bronchoalveolar lavage differ in allostimulatory potential and cytokine production. , 1996, American journal of respiratory cell and molecular biology.

[34]  S. Porcelli,et al.  A pathway of costimulation that prevents anergy in CD28- T cells: B7- independent costimulation of CD1-restricted T cells , 1995, The Journal of experimental medicine.

[35]  P. Holt,et al.  Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages , 1993, The Journal of experimental medicine.

[36]  G. Toews,et al.  Inability of human alveolar macrophages to stimulate resting T cells correlates with decreased antigen-specific T cell-macrophage binding. , 1986, Journal of immunology.

[37]  S. Spector,et al.  Standardization of bronchial inhalation challenge procedures. , 1975, The Journal of allergy and clinical immunology.

[38]  S. Ju,et al.  A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. , 2006, Journal of immunology.

[39]  F. Poccia,et al.  Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines. , 2005, Journal of immunology.

[40]  K. Austen,et al.  No audible wheezing : nuggets and conundrums from mouse asthma models , 2005 .

[41]  P. Thomas.  Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. , 2001, Immunology and cell biology.

[42]  J. Davoust,et al.  Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. , 2000, Immunity.

[43]  M. Wills-Karp.  Immunologic basis of antigen-induced airway hyperresponsiveness. , 1999, Annual review of immunology.

[44]  E. Gelfand,et al.  Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells. , 1999, Nature Network Boston.

[45]  S. Porcelli,et al.  The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. , 1999, Annual review of immunology.