Imaging pitfalls of pancreatic serous cystic neoplasm and its potential mimickers.

The aim of this article is to clarify diagnostic pitfalls of pancreatic serous cystic neoplasm (SCN) that may result in erroneous characterization. Usual and unusual imaging findings of SCN as well as potential SCN mimickers are presented. The diagnostic key of SCN is to look for a cluster of microcysts (honeycomb pattern), which may not be always found in the center. Fibrosis in SCN may be mistaken for a mural nodule of intraductal papillary mucinous neoplasm (IPMN). The absence of cyst wall enhancement may be helpful to distinguish SCN from mucinous cystic neoplasm. However, oligocystic SCN and branch duct type IPMN may morphologically overlap. In addition, solid serous adenoma, an extremely rare variant of SCN, is difficult to distinguish from neuroendocrine tumor.

[1]  安田 武生,et al.  〈症例〉男性にみられた膵 solid-pseudopapillary tumor の１切除例 , 2013 .

[2]  G. Falk,et al.  Rate of growth of pancreatic serous cystadenoma as an indication for resection. , 2013, Surgery.

[3]  H. Friess,et al.  European experts consensus statement on cystic tumours of the pancreas. , 2013, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[4]  F. Miller,et al.  Imaging features of the less common pancreatic masses , 2013, Abdominal Imaging.

[5]  Seung‐Mo Hong,et al.  Primary solid pancreatic tumors: recent imaging findings updates with pathology correlation , 2013, Abdominal Imaging.

[6]  C. F. Fernandez-del Castillo,et al.  Pancreatic cystic neoplasms: management and unanswered questions. , 2013, Gastroenterology.

[7]  Vikesh K. Singh,et al.  Should We Do EUS/FNA on Patients With Pancreatic Cysts? The Incremental Diagnostic Yield of EUS Over CT/MRI for Prediction of Cystic Neoplasms , 2013, Pancreas.

[8]  D. Sahani,et al.  Diagnosis and management of cystic pancreatic lesions. , 2013, AJR. American journal of roentgenology.

[9]  C. Bassi,et al.  Appraisal of the surgical management for pancreatic serous cystic neoplasms , 2013, Surgical Endoscopy.

[10]  J. Caracciolo,et al.  Cystic lesions of the pancreas: radiologic-endosonographic correlation. , 2012, Radiographics : a review publication of the Radiological Society of North America, Inc.

[11]  G. Sakorafas,et al.  Primary pancreatic cystic neoplasms of the pancreas revisited. Part IV: rare cystic neoplasms. , 2012, Surgical oncology.

[12]  W. Heindel,et al.  Diagnostic and radiological management of cystic pancreatic lesions: important features for radiologists. , 2012, Clinical radiology.

[13]  R. Hruban,et al.  Microcystic Serous Cystadenoma of the Pancreas With Subtotal Cystic Degeneration: Another Neoplastic Mimic of Pancreatic Pseudocyst , 2012, The American journal of surgical pathology.

[14]  Y. B. Kim,et al.  MRI features of serous oligocystic adenoma of the pancreas: differentiation from mucinous cystic neoplasm of the pancreas. , 2012, The British journal of radiology.

[15]  Jin-Young Jang,et al.  International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. , 2012, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[16]  Masao Tanaka,et al.  Multicenter Study of Serous Cystic Neoplasm of the Japan Pancreas Society , 2012, Pancreas.

[17]  K. Yoshimitsu,et al.  CT differentiation of solid serous cystadenoma vs endocrine tumor of the pancreas. , 2012, European journal of radiology.

[18]  P. Lampe,et al.  Serous neoplasms of the pancreas constitute a continuous spectrum of morphological patterns rather than distinct clinico-pathological variants. A study of 40 cases. , 2012, Polish journal of pathology : official journal of the Polish Society of Pathologists.

[19]  W. Brugge,et al.  Cyst Fluid Carcinoembryonic Antigen Is an Accurate Diagnostic Marker of Pancreatic Mucinous Cysts , 2011, Pancreas.

[20]  J. Cameron,et al.  Tumor Size and Location Correlate With Behavior of Pancreatic Serous Cystic Neoplasms , 2011, The American Journal of Gastroenterology.

[21]  A. Saftoiu,et al.  Pancreatic cyst fluid analysis--a review. , 2011, Journal of gastrointestinal and liver diseases : JGLD.

[22]  G. Sakorafas,et al.  Primary pancreatic cystic neoplasms revisited. Part I: serous cystic neoplasms. , 2011, Surgical oncology.

[23]  H. Maguchi,et al.  Clinical Features and Natural History of Serous Cystic Neoplasm of the Pancreas , 2011, Pancreatology.

[24]  James A Brink,et al.  Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee. , 2010, Journal of the American College of Radiology : JACR.

[25]  Jae Young Lee,et al.  CT imaging spectrum of pancreatic serous tumors: based on new pathologic classification. , 2010, European journal of radiology.

[26]  J. Barbour,et al.  Pancreatic Cyst: Pseudocyst or Neoplasm? Pitfalls in Endoscopic Retrograde Cholangiopancreatography Diagnosis , 2010, The American surgeon.

[27]  Yuan Ji,et al.  Solid Pseudopapillary Tumor of the Pancreas: Cross-Sectional Imaging and Pathologic Correlation , 2010, Pancreas.

[28]  Kisha Mitchell,et al.  Serous Cystadenoma in Communication With the Pancreatic Duct: An Unusual Radiologic and Pathologic Entity , 2010, Journal of clinical gastroenterology.

[29]  R. Hruban,et al.  Multiple Endocrine Neoplasms and Serous Cysts of the Pancreas in a Patient with von Hippel-Lindau Disease , 2010, Journal of gastrointestinal cancer.

[30]  Diego R. Martín,et al.  MR imaging of cystic lesions of the pancreas. , 2009, Radiographics : a review publication of the Radiological Society of North America, Inc.

[31]  J. H. Lim,et al.  Macrocystic pancreatic lesions: differentiation of benign from premalignant and malignant cysts by CT. , 2009, European journal of radiology.

[32]  Myeong-Jin Kim,et al.  Typical and atypical manifestations of serous cystadenoma of the pancreas: imaging findings with pathologic correlation. , 2009, AJR. American journal of roentgenology.

[33]  H. Kuwano,et al.  Macrocystic serous cystadenoma mimicking branch duct intraductal papillary mucinous neoplasm. , 2009, International surgery.

[34]  N. Agarwal,et al.  Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature. , 2009, JOP : Journal of the pancreas.

[35]  D. Santini,et al.  Serous Cystic Tumors of the Pancreas: When to Observe and When to Operate , 2008, Digestive Surgery.

[36]  M. A. Machado,et al.  Solid serous adenoma of the pancreas: an uncommon but important entity. , 2008, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[37]  N. Takahashi,et al.  CT findings of walled-off pancreatic necrosis (WOPN): differentiation from pseudocyst and prediction of outcome after endoscopic therapy , 2008, European Radiology.

[38]  Jin‐Young Jang,et al.  The Morphological Classification of a Serous Cystic Tumor (SCT) of the Pancreas and Evaluation of the Preoperative Diagnostic Accuracy of Computed Tomography , 2008, Annals of Surgical Oncology.

[39]  Sukant Garg,et al.  Combined serous cystadenoma and pancreatic endocrine neoplasm. A case report with a brief review of the literature. , 2007, JOP : Journal of the pancreas.

[40]  John L. Cameron,et al.  Resected Serous Cystic Neoplasms of the Pancreas: A Review of 158 Patients with Recommendations for Treatment , 2007, Journal of Gastrointestinal Surgery.

[41]  W. Frankel,et al.  Solid serous microcystic adenoma of the pancreas , 2007, World journal of surgical oncology.

[42]  D. Longnecker,et al.  Solid Serous Adenoma of the Pancreas: A Rare Variant Within the Family of Pancreatic Serous Cystic Neoplasms , 2006, Pancreas.

[43]  S. Pizzi,et al.  Three cases of pancreatic serous cystadenoma and endocrine tumour , 2006, Journal of Clinical Pathology.

[44]  O. Matsui,et al.  Solid serous cystadenoma of the pancreas: MR imaging with pathologic correlation , 2005, Abdominal Imaging.

[45]  R. Nayar,et al.  Microcystic adenoma of the pancreas , 2004, Cancer.

[46]  K. Batts,et al.  Lymphoepithelial Cysts of the Pancreas: a Report of 12 Cases and a Review of the Literature , 2002, Modern Pathology.

[47]  D. Klimstra,et al.  Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts. , 2000, Seminars in diagnostic pathology.

[48]  R. Talukdar,et al.  Treatment of pancreatic cystic neoplasm: surgery or conservative? , 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[49]  M. Mcphail,et al.  Endoscopic ultrasound guided fine needle aspiration for the diagnosis of pancreatic cystic neoplasms: a meta-analysis. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[50]  M. Tsuneyoshi,et al.  Three Cases of Serous Oligocystic Adenomas of the Pancreas; Evaluation of Cyst Wall Thickness for Preoperative Differentiation from Mucinous Cystic Neoplasms , 2007, Journal of gastrointestinal cancer.

[51]  MMed Brian K.P. Goh MBBS,et al.  Pancreatic Serous Oligocystic Adenomas: Clinicopathologic Features and a Comparison with Serous Microcystic Adenomas and Mucinous Cystic Neoplasms , 2005, World Journal of Surgery.

[52]  N. Merrett,et al.  SEROUS OLIGOCYSTIC ADENOMA OF THE PANCREAS: A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF THREE CASES WITH ULTRASTRUCTURAL FINDINGS , 2002, Pathology.