Diagnostic values of DAS28 and DAS28-squeeze in evaluating Rheumatoid Arthritis disease

which is an active Doppler signal with a moderate synovial hypertrophy on B-mode. Results : Over the study period, 56 subjects underwent diagnostic tests using DAS28, DAS28-squeeze and Power Doppler sonography. There were 4 false negative cases in DAS28 and 1 case in DAS28-squeeze. The sensitivities of DAS28 and DAS28-squeeze to identify active disease using Power Doppler sonography as reference standard were 73.3% (95%CI ± 11.59) and 93.3% (95%CI ± 6.55), respectively. While the specificities of DAS28 and DAS28-squeeze were 36.6% (95%CI ± 12.62) and 34.1% (95%CI ± 12.42), respectively. Furthermore the negative likelihood ratio of DAS28 and DAS28-squeeze were 0.73 and 0.19, respectively. Conclusion : This study is the first to validate DAS28-squeeze using imaging techniques. From this study the false negative rate of DAS28-squeeze is lower than DAS28. DAS28-squeeze has a better sensitivity and negative likelihood ratio than DAS28 in identifying RA disease state.

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