Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.

[1]  Soon Wen Hoh,et al.  The CCP4 suite: integrative software for macromolecular crystallography , 2023, Acta crystallographica. Section D, Structural biology.

[2]  Marcella H. Boynton,et al.  Microbial β-glucuronidases drive human periodontal disease etiology , 2023, Science advances.

[3]  M. Redinbo,et al.  Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response , 2023, Gut microbes.

[4]  Wafaa R. Mohamed,et al.  Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity , 2023, BMC Microbiology.

[5]  Edoardo Pasolli,et al.  Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4 , 2023, Nature Biotechnology.

[6]  Cathy H. Wu,et al.  UniProt: the Universal Protein Knowledgebase in 2023 , 2022, Nucleic Acids Res..

[7]  M. Redinbo,et al.  Multi-omic analysis of host-microbial interactions central to the gut-brain axis. , 2022, Molecular omics.

[8]  Christian J. A. Sigrist,et al.  Annotation of biologically relevant ligands in UniProtKB using ChEBI , 2022, bioRxiv.

[9]  R. Kaplan,et al.  Spotlight on the Gut Microbiome in Menopause: Current Insights , 2022, International journal of women's health.

[10]  M. Redinbo,et al.  A structural metagenomics pipeline for examining the gut microbiome. , 2022, Current opinion in structural biology.

[11]  S. Ovchinnikov,et al.  ColabFold: making protein folding accessible to all , 2022, Nature Methods.

[12]  Laura E. Herring,et al.  Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate , 2022, medRxiv.

[13]  C. Derby,et al.  Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos , 2022, mSystems.

[14]  Asha A. Nair,et al.  Gut Microbial β-Glucuronidases Regulate Host Luminal Proteases and are depleted in Irritable Bowel Syndrome , 2022, Nature Microbiology.

[15]  A. Hajnal,et al.  Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling , 2022, Biomedicines.

[16]  M. Redinbo,et al.  Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract , 2022, Nature communications.

[17]  Konstantinos D. Tsirigos,et al.  SignalP 6.0 predicts all five types of signal peptides using protein language models , 2022, Nature Biotechnology.

[18]  A. Ardizzoni,et al.  Psychiatric Adverse Reactions to Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer: Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System , 2022, Targeted Oncology.

[19]  Kun Lu,et al.  High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice , 2021, Nature Communications.

[20]  B. Shao,et al.  The efficacy and safety of palbociclib combined with endocrine therapy in patients with hormone receptor-positive HER2-negative advanced breast cancer: a multi-center retrospective analysis , 2021, Anti-cancer drugs.

[21]  J. Petriczko,et al.  Microbiome Metabolites and Thyroid Dysfunction , 2021, Journal of clinical medicine.

[22]  Oriol Vinyals,et al.  Highly accurate protein structure prediction with AlphaFold , 2021, Nature.

[23]  Robert C. Edgar,et al.  Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny , 2021, bioRxiv.

[24]  Zongxin Ling,et al.  Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease , 2021, Frontiers in Aging Neuroscience.

[25]  H. Drost,et al.  Sensitive protein alignments at tree-of-life scale using DIAMOND , 2021, Nature Methods.

[26]  I. Charles,et al.  Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation , 2021, NPJ Parkinson's disease.

[27]  S. Roffler,et al.  Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity , 2021, Communications biology.

[28]  Hsin-Yi Lai,et al.  The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis , 2021, Frontiers in Aging Neuroscience.

[29]  A. Serretti,et al.  Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis , 2021, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[30]  H. Soininen,et al.  Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease , 2021, Alzheimer's research & therapy.

[31]  Zhe-Shan Quan,et al.  Piperazine skeleton in the structural modification of natural products: a review , 2021, Journal of enzyme inhibition and medicinal chemistry.

[32]  A. Dhingra,et al.  Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential , 2020, Drug Research.

[33]  Peter B. McGarvey,et al.  UniProt: the universal protein knowledgebase in 2021 , 2020, Nucleic Acids Res..

[34]  P. Manghi,et al.  Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3 , 2020, bioRxiv.

[35]  A. Shaw,et al.  First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer. , 2020, The New England journal of medicine.

[36]  A. Riegel,et al.  An evaluation of palbociclib as a breast cancer treatment option: a current update , 2020, Expert opinion on pharmacotherapy.

[37]  L. Shao,et al.  Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease , 2020, Frontiers in Cellular and Infection Microbiology.

[38]  M. Redinbo,et al.  Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. , 2020, Biochemistry.

[39]  Ji-long Yao,et al.  Association between premature ovarian insufficiency and gut microbiota , 2020, BMC Pregnancy and Childbirth.

[40]  Nicholas Tsouklidis,et al.  How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome , 2020, Cureus.

[41]  Shengdi Chen,et al.  Gut metagenomics-derived genes as potential biomarkers of Parkinson's disease. , 2020, Brain : a journal of neurology.

[42]  Robert D. Finn,et al.  A unified catalog of 204,938 reference genomes from the human gut microbiome , 2020, Nature Biotechnology.

[43]  M. Redinbo,et al.  The Gut Microbiota Impact Cancer Etiology through “Phase IV Metabolism” of Xenobiotics and Endobiotics , 2020, Cancer Prevention Research.

[44]  K. Amrein,et al.  Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function? , 2020, Nutrients.

[45]  Yuan Yuan,et al.  Efficacy and safety of ceritinib in anaplastic lymphoma kinase‐rearranged non‐small cell lung cancer: A systematic review and meta‐analysis , 2020, Journal of clinical pharmacy and therapeutics.

[46]  David B. Darr,et al.  Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy , 2020, Proceedings of the National Academy of Sciences.

[47]  S. Akhondzadeh,et al.  Vortioxetine effects on quality of life of irritable bowel syndrome patients: A randomized, double‐blind, placebo‐controlled trial , 2020, Journal of clinical pharmacy and therapeutics.

[48]  Paul Awolade,et al.  Therapeutic significance of β-glucuronidase activity and its inhibitors: A review , 2019, European Journal of Medicinal Chemistry.

[49]  H. Overkleeft,et al.  Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. , 2019, ACS chemical biology.

[50]  Olga Chernomor,et al.  IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era , 2019, bioRxiv.

[51]  K. Pearce,et al.  Targeting regorafenib-induced toxicity through inhibition of gut microbial β-glucuronidases. , 2019, ACS chemical biology.

[52]  M. Redinbo,et al.  Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens , 2019, The Journal of Biological Chemistry.

[53]  Kieran Rea,et al.  The Microbiota-Gut-Brain Axis. , 2019, Physiological reviews.

[54]  T. Dinan,et al.  Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis. , 2019, Current opinion in pharmacology.

[55]  A. Page,et al.  The gut microbiome regulates host glucose homeostasis via peripheral serotonin , 2019, Proceedings of the National Academy of Sciences.

[56]  F. Bonfiglio,et al.  Evaluation of Rapid Library Preparation Protocols for Whole Genome Sequencing Based Outbreak Investigation , 2019, Front. Public Health.

[57]  Cora O'Neill,et al.  Gut microbes metabolize Parkinson's disease drug , 2019, Science.

[58]  Kevin S. Bonham,et al.  Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases , 2019, Nature.

[59]  Amal E. Ali,et al.  Azoreductase activity of dye-decolorizing bacteria isolated from the human gut microbiota , 2019, Scientific Reports.

[60]  J. Tap,et al.  Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis , 2019, Microbiome.

[61]  M. Redinbo,et al.  Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome. , 2019, Journal of molecular biology.

[62]  D. Erie,et al.  Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases , 2019, Scientific Reports.

[63]  A. Keshavarzian,et al.  Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease , 2019, Nature Communications.

[64]  J. Khlevner,et al.  Brain-Gut Axis: Clinical Implications. , 2018, Gastroenterology clinics of North America.

[65]  Davide Heller,et al.  eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses , 2018, Nucleic Acids Res..

[66]  A. Goodman,et al.  Mucosal homeostasis is altered in the ileum of gnotobiotic mice. , 2018, The Journal of surgical research.

[67]  Matthew R. Redinbo,et al.  Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis , 2018, The Journal of Biological Chemistry.

[68]  S. Benvenga,et al.  Gut microbiota and Hashimoto’s thyroiditis , 2018, Reviews in Endocrine and Metabolic Disorders.

[69]  Qin Liu,et al.  Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis , 2018, BioMed research international.

[70]  Xiling Shen,et al.  A gut-brain neural circuit for nutrient sensory transduction , 2018, Science.

[71]  Hongwei Zhou,et al.  Gut microbiota in patients with Parkinson's disease in southern China. , 2018, Parkinsonism & related disorders.

[72]  Philip Strandwitz Neurotransmitter modulation by the gut microbiota , 2018, Brain Research.

[73]  Juan M. Astorga,et al.  Breast Cancer and Its Relationship with the Microbiota , 2018, International journal of environmental research and public health.

[74]  M. Redinbo,et al.  Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception , 2018, ACS central science.

[75]  S. Ziaei,et al.  The association between estradiol levels and cognitive function in postmenopausal women , 2018, International journal of reproductive biomedicine.

[76]  E. Balskus,et al.  Deciphering Human Gut Microbiota-Nutrient Interactions: A Role for Biochemistry. , 2018, Biochemistry.

[77]  Peer Bork,et al.  Extensive impact of non-antibiotic drugs on human gut bacteria , 2018, Nature.

[78]  Huinan Chen,et al.  Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients. , 2018, Thyroid : official journal of the American Thyroid Association.

[79]  E. Fliers,et al.  The classic pathways of thyroid hormone metabolism , 2017, Molecular and Cellular Endocrinology.

[80]  Zhibin Ning,et al.  MetaLab: an automated pipeline for metaproteomic data analysis , 2017, Microbiome.

[81]  Xiaokang Wu,et al.  Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[82]  Sylvia Daunert,et al.  Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis , 2017, Journal of cellular physiology.

[83]  M. Herbst-Kralovetz,et al.  Estrogen-gut microbiome axis: Physiological and clinical implications. , 2017, Maturitas.

[84]  Kazufumi Yoshihara,et al.  Regulation of gut luminal serotonin by commensal microbiota in mice , 2017, PloS one.

[85]  M. Redinbo,et al.  An Atlas of β-Glucuronidases in the Human Intestinal Microbiome. , 2017, Structure.

[86]  A. Ryan Azoreductases in drug metabolism , 2017, British journal of pharmacology.

[87]  E. Balskus,et al.  Chemical transformation of xenobiotics by the human gut microbiota , 2017, Science.

[88]  G. A. van der Marel,et al.  Activity-based probes for functional interrogation of retaining β-glucuronidases. , 2017, Nature chemical biology.

[89]  Remington Nevin A serious nightmare: psychiatric and neurologic adverse reactions to mefloquine are serious adverse reactions , 2017, Pharmacology research & perspectives.

[90]  Kim-Anh Lê Cao,et al.  mixOmics: An R package for ‘omics feature selection and multiple data integration , 2017, bioRxiv.

[91]  James T. Morton,et al.  Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome , 2017, Movement disorders : official journal of the Movement Disorder Society.

[92]  M. Redinbo,et al.  Glucuronides in the gut: Sugar-driven symbioses between microbe and host , 2017, The Journal of Biological Chemistry.

[93]  A. Lerner,et al.  Gut-thyroid axis and celiac disease , 2017, Endocrine connections.

[94]  John F. Cryan,et al.  Stress & the gut-brain axis: Regulation by the microbiome , 2017, Neurobiology of Stress.

[95]  R. Price,et al.  Adverse effects of mefloquine for the treatment of uncomplicated malaria in Thailand: A pooled analysis of 19, 850 individual patients , 2017, PloS one.

[96]  M. Redinbo Microbial Molecules from the Multitudes within Us. , 2017, Cell metabolism.

[97]  C. Virili,et al.  “With a little help from my friends” - The role of microbiota in thyroid hormone metabolism and enterohepatic recycling , 2017, Molecular and Cellular Endocrinology.

[98]  Guangchuang Yu,et al.  ggtree: an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data , 2017 .

[99]  Jüergen Cox,et al.  The MaxQuant computational platform for mass spectrometry-based shotgun proteomics , 2016, Nature Protocols.

[100]  Gonzalo Viana Di Prisco,et al.  Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring , 2016, Cell.

[101]  D. Drossman,et al.  Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction. , 2016, Gastroenterology.

[102]  Peer Bork,et al.  MOCAT2: a metagenomic assembly, annotation and profiling framework , 2016, Bioinform..

[103]  C. Baik,et al.  Proactive management strategies for potential gastrointestinal adverse reactions with ceritinib in patients with advanced ALK-positive non-small-cell lung cancer , 2016, Cancer management and research.

[104]  Hang Xiao,et al.  High-fat-diet-induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches. , 2016, Nutrition.

[105]  S. Nyberg,et al.  Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models , 2016, British journal of pharmacology.

[106]  H. Reichmann,et al.  Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors , 2015, Nature Reviews Neurology.

[107]  Peer Bork,et al.  The SIDER database of drugs and side effects , 2015, Nucleic Acids Res..

[108]  S. Frye,et al.  Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. , 2015, Chemistry & biology.

[109]  A. Parkinson,et al.  Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor , 2015, Drug Metabolism and Disposition.

[110]  C. Sánchez,et al.  Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism , 2015, Journal of psychopharmacology.

[111]  D. Kendig,et al.  Serotonin and colonic motility , 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[112]  Rustem F. Ismagilov,et al.  Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis , 2015, Cell.

[113]  E. Pekkonen,et al.  Gut microbiota are related to Parkinson's disease and clinical phenotype , 2015, Movement disorders : official journal of the Movement Disorder Society.

[114]  T. Dinan,et al.  Serotonin, tryptophan metabolism and the brain-gut-microbiome axis , 2015, Behavioural Brain Research.

[115]  R. Knight,et al.  Gut Microbes and the Brain: Paradigm Shift in Neuroscience , 2014, The Journal of Neuroscience.

[116]  P. Vrtačnik,et al.  The many faces of estrogen signaling , 2014, Biochemia medica.

[117]  Jens Roat Kultima,et al.  An integrated catalog of reference genes in the human gut microbiome , 2014, Nature Biotechnology.

[118]  M. DeVito,et al.  In vitro metabolism of thyroxine by rat and human hepatocytes , 2014, Xenobiotica; the fate of foreign compounds in biological systems.

[119]  G. Brent,et al.  Thyroid hormone regulation of metabolism. , 2014, Physiological reviews.

[120]  K. Dahlman-Wright,et al.  Estrogen receptor beta in breast cancer , 2014, Molecular and Cellular Endocrinology.

[121]  L. Citrome Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant – what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? , 2014, International journal of clinical practice.

[122]  F. López-Muñoz,et al.  Active Metabolites as Antidepressant Drugs: The Role of Norquetiapine in the Mechanism of Action of Quetiapine in the Treatment of Mood Disorders , 2013, Front. Psychiatry.

[123]  P. Turnbaugh,et al.  Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta , 2013, Science.

[124]  A. I. Valenciano,et al.  The arylalkylamine-N-acetyltransferase (AANAT) acetylates dopamine in the digestive tract of goldfish: A role in intestinal motility , 2013, Neurochemistry International.

[125]  M. Gershon 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract , 2013, Current opinion in endocrinology, diabetes, and obesity.

[126]  D. Sibon,et al.  Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks. , 2013, ACS chemical neuroscience.

[127]  J. Bienenstock,et al.  Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents. , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[128]  H. Gharib,et al.  Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. , 2012, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[129]  Kazufumi Yoshihara,et al.  Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[130]  Katherine H. Huang,et al.  A framework for human microbiome research , 2012, Nature.

[131]  J. Doré,et al.  Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice , 2012, Mucosal Immunology.

[132]  Heidi Koldsø,et al.  Synthesis of uronic-noeurostegine--a potent bacterial β-glucuronidase inhibitor. , 2011, Organic & biomolecular chemistry.

[133]  T. Dinan,et al.  Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve , 2011, Proceedings of the National Academy of Sciences.

[134]  Victor M Montori,et al.  Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. , 2011, Thyroid : official journal of the American Thyroid Association.

[135]  John E. Scott,et al.  A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors , 2011, Current chemical genomics.

[136]  G. Canonica,et al.  Antihistaminic, Anti-Inflammatory, and Antiallergic Properties of the Nonsedating Second-Generation Antihistamine Desloratadine: A Review of the Evidence , 2011, The World Allergy Organization journal.

[137]  H. Forssberg,et al.  Normal gut microbiota modulates brain development and behavior , 2011, Proceedings of the National Academy of Sciences.

[138]  John E. Scott,et al.  Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme , 2010, Science.

[139]  Thomas L. Madden,et al.  BLAST+: architecture and applications , 2009, BMC Bioinformatics.

[140]  B. Roth,et al.  The expanded biology of serotonin. , 2009, Annual review of medicine.

[141]  M. Nakajima,et al.  Glucuronidation of Thyroxine in Human Liver, Jejunum, and Kidney Microsomes , 2007, Drug Metabolism and Disposition.

[142]  D. Nutt,et al.  Tryptophan metabolism in the central nervous system: medical implications , 2006, Expert Reviews in Molecular Medicine.

[143]  R. Sartor Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis , 2006, Nature Clinical Practice Gastroenterology &Hepatology.

[144]  Adam Godzik,et al.  Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences , 2006, Bioinform..

[145]  L. Rodrigo,et al.  Acute cholestasis related to desloratidine. , 2005, World journal of gastroenterology.

[146]  Vincent Lombard,et al.  The EMBL Nucleotide Sequence Database , 2004, Nucleic Acids Res..

[147]  P. Emsley,et al.  Coot: model-building tools for molecular graphics. , 2004, Acta crystallographica. Section D, Biological crystallography.

[148]  K. Korach,et al.  The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling* , 2001, The Journal of Biological Chemistry.

[149]  E. Meltzer,et al.  Desloratadine: A new, nonsedating, oral antihistamine. , 2001, The Journal of allergy and clinical immunology.

[150]  G. Hager,et al.  Trafficking of nuclear receptors in living cells , 2000, The Journal of Steroid Biochemistry and Molecular Biology.

[151]  M. A. Rahman,et al.  Enterohepatic recycling of estrogen and its relevance with female fertility , 2000, Archives of pharmacal research.

[152]  T. Vree,et al.  Enterohepatic Cycling and Pharmacokinetics of Oestradiol in Postmenopausal Women , 1998, The Journal of pharmacy and pharmacology.

[153]  É. Mezey,et al.  Substantial production of dopamine in the human gastrointestinal tract. , 1997, The Journal of clinical endocrinology and metabolism.

[154]  T. Visser,et al.  Enterohepatic circulation of triiodothyronine (T3) in rats: importance of the microflora for the liberation and reabsorption of T3 from biliary T3 conjugates. , 1989, Endocrinology.

[155]  J. DiStefano Excretion, Metabolism and Enterohepatic Circulation Pathways and Their Role in Overall Thyroid Hormone Regulation in the Rat , 1988 .

[156]  T. Visser,et al.  Hydrolysis of iodothyronine glucuronides by obligately anaerobic bacteria isolated from human faecal flora , 1986 .

[157]  T. Visser,et al.  Iodothyronine sulfate‐hydrolyzing anaerobic bacteria isolated from human fecal flora , 1985 .

[158]  D. Savage,et al.  Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract , 1974, Infection and immunity.

[159]  G. A. Levvy The preparation and properties of β-glucuronidase. 4. Inhibition by sugar acids and their lactones , 1952 .

[160]  OUP accepted manuscript , 2021, Nucleic Acids Research.

[161]  M. Gareau Microbiota-gut-brain axis and cognitive function. , 2014, Advances in experimental medicine and biology.

[162]  P. Masand,et al.  A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome. , 2009, Psychosomatics.

[163]  P. Plenge,et al.  High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes , 2006, Psychopharmacology.

[164]  M. Caira,et al.  Pathways of Biotransformation — Phase II Reactions , 2005 .

[165]  M. Lazar,et al.  The mechanism of action of thyroid hormones. , 2000, Annual review of physiology.

[166]  R. Price,et al.  Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients. , 1995, Bulletin of the World Health Organization.

[167]  T. Visser,et al.  On the enterohepatic cycle of triiodothyronine in rats; importance of the intestinal microflora. , 1989, Life sciences.

[168]  Randy J Read,et al.  Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination , 2022 .