Embryonal carcinoma cells (and their somatic cell hybrids) are resistant to infection by the murine parvovirus MVM, which does infect other teratocarcinoma‐derived cell lines

Minute virus of mice (MVM), a non‐defective parvovirus, has been shown to infect cultures of non‐pluripotent differentiated teratocarcinoma‐derived cells, but pluripotent (and “nullipotent”) embryonal carcinoma cells derived from the same teratocarcinoma resist MVN infection. Somatic cell hybrids between an embryonal carcinoma line and Friend erythroblastic leukemia cells are also resistant to MVM, even though Friend cells are susceptible. Among three blastocyst‐derived lines tested, only one, a parietal yolk sac cell line, resists MVM infection. These results suggest that teratocarcinoma cultures may provide useful systems in which to study the cellular factors which mediate susceptibility to this teratogenic and oncolytic virus.

[1]  R. Miller,et al.  Histologic analyses of experimental tumors from mouse blastocyst-derived cell lines. , 1977, Journal of the National Cancer Institute.

[2]  F. Ruddle,et al.  Teratocarcinoma X friend erythroleukemia cell hybrids resemble their pluripotent embryonal carcinoma parent. , 1977, Developmental biology.

[3]  D. Ward,et al.  Three structural polypeptides coded for by minite virus of mice, a parvovirus , 1976, Journal of virology.

[4]  Frank H. Ruddle,et al.  Pluripotent teratocarcinoma-thymus somatic cell hybrids , 1976, Cell.

[5]  M. Boccara,et al.  Susceptibility of teratocarcinoma cells to adenovirus type 2 , 1976, Nature.

[6]  D. Campbell,et al.  Immunosuppressive activity of a subline of the mouse EL-4 lymphoma. Evidence for minute virus of mice causing the inhibition , 1976, The Journal of experimental medicine.

[7]  M. Evans,et al.  Fate of teratocarcinoma cells injected into early mouse embryos , 1975, Nature.

[8]  K. Illmensee,et al.  Normal genetically mosaic mice produced from malignant teratocarcinoma cells. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[9]  G. Tomkins,et al.  “Superinduction” of tyrosine aminotransferase by actinomycin D: a reevaluation , 1975, Cell.

[10]  M. Sherman Long term culture of cells derived from mouse blastocysts. , 1975, Differentiation; research in biological diversity.

[11]  D. Swartzendruber,et al.  Neoplastic differentiation: Interaction of simian virus 40 and polyoma virus with murine teratocarcinoma cells in vitro , 1975, Journal of cellular physiology.

[12]  M. Evans,et al.  Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[13]  R. Brinster THE EFFECT OF CELLS TRANSFERRED INTO THE MOUSE BLASTOCYST ON SUBSEQUENT DEVELOPMENT , 1974, The Journal of experimental medicine.

[14]  A. Shatkin,et al.  Replication of the Parvovirus MVM II. Isolation and Characterization of Intermediates in the Replication of the Viral Deoxyribonucleic Acid , 1973, Journal of virology.

[15]  F. Ruddle,et al.  Expression of liver phenotypes in cultured mouse hepatoma cells: synthesis and secretion of serum albumin. , 1973, Developmental biology.

[16]  S. Rhode Replication Process of the Parvovirus H-1 I. Kinetics in a Parasynchronous Cell System , 1973, Journal of virology.

[17]  M. Gautschi,et al.  The multiplication of parvovirus Lu3 in a synchronized culture system. I. Optimum conditions for virus replication. , 1973, Archiv fur die gesamte Virusforschung.

[18]  P. Tattersall Replication of the Parvovirus MVM I. Dependence of Virus Multiplication and Plaque Formation on Cell Growth , 1972, Journal of virology.

[19]  R. Tennant,et al.  Requirement of cellular synthesis for Kilham rat virus replication. , 1970, Virology.

[20]  H. Toolan,et al.  Lack of Oncogenic Effect of the H-Viruses for Hamsters , 1967, Nature.

[21]  R. H. Johnson,et al.  Feline panleucopaenia virus. II. Some features of the cytopathic effects in feline kidney monolayers. , 1965, Research in veterinary science.

[22]  J. Littlefield Three Degrees of Guanylic Acid — Inosinic Acid Pyrophosphorylase Deficiency in Mouse Fibroblasts , 1964, Nature.

[23]  H. Mcdevitt,et al.  PURIFICATION AND ANALYSIS OF FLUORESCEIN-LABELED ANTISERA BY COLUMN CHROMATOGRAPHY. , 1963, Journal of immunology.