Development of antidotes: problems and strategies.

[1]  P. Eyer,et al.  Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds. , 2006, Biochemical pharmacology.

[2]  P. Eyer,et al.  Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators. , 2006, Biochemical pharmacology.

[3]  J. Moran,et al.  Oxime therapy and outcomes in human organophosphate poisoning: An evaluation using meta-analytic techniques , 2006, Critical care medicine.

[4]  P. Eyer,et al.  Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning. , 2005, Chemico-biological interactions.

[5]  P. Eyer,et al.  Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. , 2005, Toxicology and applied pharmacology.

[6]  P. Aisen,et al.  Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman. , 2005, Chemico-biological interactions.

[7]  P. Eyer,et al.  Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. , 2005, Toxicology.

[8]  P. Eyer,et al.  Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. , 2004, Biochemical pharmacology.

[9]  P. Eyer,et al.  Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates , 2002, Archives of Toxicology.

[10]  M. Eddleston,et al.  Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. , 2002, QJM : monthly journal of the Association of Physicians.

[11]  R. Ridi,et al.  Tissue engineering with HaCaT cells and a fibroblast cell line , 1999, Archives of Dermatological Research.

[12]  P. Eyer,et al.  Improved determination of acetylcholinesterase activity in human whole blood. , 1999, Clinica chimica acta; international journal of clinical chemistry.

[13]  P. Eyer,et al.  Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients , 1997, Human & experimental toxicology.

[14]  T. Kirchner,et al.  Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin. , 1995, Toxicology.

[15]  R. Dawson,et al.  Review of oximes available for treatment of nerve agent poisoning , 1994, Journal of applied toxicology : JAT.

[16]  H. J. Silva,et al.  Does pralidoxime affect outcome of management in acute organophosphorus poisoning? , 1992, The Lancet.

[17]  B. Ballantyne,et al.  Clinical and Experimental Toxicology of Organophosphates and Carbamates , 1992 .

[18]  D. M. Maxwell,et al.  The role of carboxylesterase in species variation of oxime protection against soman , 1991, Neuroscience & Biobehavioral Reviews.

[19]  J. Petrali,et al.  Molecular basis for mustard-induced vesication. , 1985, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[20]  E. Albuquerque,et al.  The interaction of anticholinesterase agents with the acetylcholine receptor-ionic channel complex , 1984 .

[21]  O. Wolthuis,et al.  Therapy of organophosphate poisoning: the marmoset as a model for man , 1983, British journal of pharmacology.

[22]  P. DIRNHUBER,et al.  The protection of primates against soman poisoning by pretreatment with pyridostigmine , 1979, The Journal of pharmacy and pharmacology.

[23]  W. K. Berry.  Some species differences in the rates of reaction of diaphragm particulate acetylcholinesterases with tetraethyl pyrophosphate and pralidoxime. , 1971, Biochemical pharmacology.

[24]  D. R. Davies,et al.  The use of carbamates and atropine in the protection of animals against poisoning by 1,2,2-trimethylpropyl methylphosphonofluoridate. , 1970, Biochemical pharmacology.

[25]  L. Harris,et al.  Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolyl methylphosphonofluoridate. , 1965, Biochemical pharmacology.

[26]  G. Koelle.  Protection of cholinesterase against irreversible inactivation by di-isopropyl fluorophosphate in vitro. , 1946, The Journal of pharmacology and experimental therapeutics.

[27]  T. Kirchner,et al.  Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds , 1996, Archives of Toxicology.

[28]  B. Ballantyne,et al.  1 – Overview of the biological and clinical aspects of organophosphates and carbamates , 1992 .

[29]  D. Grob.  Anticholinesterase Intoxication in Man and its Treatment , 1963 .