Injectable PLGA microspheres with tunable magnesium ion release for promoting bone regeneration.

[1]  Jiang Chang,et al.  Bioceramics to regulate stem cells and their microenvironment for tissue regeneration , 2019, Materials Today.

[2]  Pengfei Wei,et al.  Bioresorbable Microspheres with Surface-Loaded Nanosilver and Apatite as Dual-Functional Injectable Cell Carriers for Bone Regeneration. , 2018, Macromolecular rapid communications.

[3]  Yufeng Zheng,et al.  Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration. , 2018, Biomaterials.

[4]  K. W. Lo,et al.  The roles of ions on bone regeneration. , 2018, Drug discovery today.

[5]  Julian R. Jones,et al.  In vitro osteogenesis by intracellular uptake of strontium containing bioactive glass nanoparticles. , 2018, Acta biomaterialia.

[6]  Chengtie Wu,et al.  Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration. , 2018, Acta biomaterialia.

[7]  Huan Zhou,et al.  Magnesium-based bioceramics in orthopedic applications. , 2018, Acta biomaterialia.

[8]  Liming Bian,et al.  Nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration. , 2017, Acta biomaterialia.

[9]  Aldo R Boccaccini,et al.  Regenerating bone with bioactive glass scaffolds: A review of in vivo studies in bone defect models. , 2017, Acta biomaterialia.

[10]  K. Balagangadharan,et al.  Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering. , 2017, International journal of biological macromolecules.

[11]  Z. Gou,et al.  Enhancing the Osteogenic Capability of Core-Shell Bilayered Bioceramic Microspheres with Adjustable Biodegradation. , 2017, ACS applied materials & interfaces.

[12]  Lina Zhang,et al.  Hierarchical Microspheres Constructed from Chitin Nanofibers Penetrated Hydroxyapatite Crystals for Bone Regeneration. , 2017, Biomacromolecules.

[13]  Q. Cai,et al.  Repairing a bone defect with a three-dimensional cellular construct composed of a multi-layered cell sheet on electrospun mesh , 2017, Biofabrication.

[14]  Seok-Jo Yang,et al.  Magnesium ions enhance infiltration of osteoblasts in scaffolds via increasing cell motility , 2017, Journal of Materials Science: Materials in Medicine.

[15]  Hongchen Liu,et al.  Porous Nanohydroxyapatite/Collagen Scaffolds Loading Insulin PLGA Particles for Restoration of Critical Size Bone Defect. , 2017, ACS applied materials & interfaces.

[16]  G. Yuan,et al.  Facile Preparation of Poly(lactic acid)/Brushite Bilayer Coating on Biodegradable Magnesium Alloys with Multiple Functionalities for Orthopedic Application. , 2017, ACS applied materials & interfaces.

[17]  Donghui Wang,et al.  Multifunctions of dual Zn/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants. , 2017, Acta biomaterialia.

[18]  Xing‐dong Zhang,et al.  Vascularization in Engineered Tissue Construct by Assembly of Cellular Patterned Micromodules and Degradable Microspheres. , 2017, ACS applied materials & interfaces.

[19]  Guang-hong Zhou,et al.  Mg alloy rod reinforced biodegradable poly-lactic acid composite for load bearing bone replacement , 2017 .

[20]  Kinam Park,et al.  PLA micro- and nano-particles. , 2016, Advanced drug delivery reviews.

[21]  Y. Ramot,et al.  Biocompatibility and safety of PLA and its copolymers. , 2016, Advanced drug delivery reviews.

[22]  Henry Brem,et al.  Polylactic acid (PLA) controlled delivery carriers for biomedical applications. , 2016, Advanced drug delivery reviews.

[23]  D. Schaubroeck,et al.  Novel injectable, self-gelling hydrogel–microparticle composites for bone regeneration consisting of gellan gum and calcium and magnesium carbonate microparticles , 2016, Biomedical materials.

[24]  Yuan Yuan,et al.  Magnesium modification up-regulates the bioactivity of bone morphogenetic protein-2 upon calcium phosphate cement via enhanced BMP receptor recognition and Smad signaling pathway. , 2016, Colloids and surfaces. B, Biointerfaces.

[25]  Yufeng Zheng,et al.  Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats , 2016, Nature Medicine.

[26]  Prashant N. Kumta,et al.  Magnesium Phosphate Cement Systems for Hard Tissue Applications: A Review. , 2016, ACS biomaterials science & engineering.

[27]  P. Ma,et al.  Dentin regeneration by stem cells of apical papilla on injectable nanofibrous microspheres and stimulated by controlled BMP-2 release. , 2016, Acta biomaterialia.

[28]  H. Liu,et al.  Concentration-dependent behaviors of bone marrow derived mesenchymal stem cells and infectious bacteria toward magnesium oxide nanoparticles. , 2016, Acta biomaterialia.

[29]  J. Granjeiro,et al.  Osteogenic effect of tricalcium phosphate substituted by magnesium associated with Genderm® membrane in rat calvarial defect model. , 2016, Materials science & engineering. C, Materials for biological applications.

[30]  P. Ma,et al.  Nanofibrous spongy microspheres for the delivery of hypoxia-primed human dental pulp stem cells to regenerate vascularized dental pulp. , 2016, Acta biomaterialia.

[31]  R. Benavente,et al.  In vitro degradation of biodegradable polylactic acid/magnesium composites: Relevance of Mg particle shape. , 2016, Acta biomaterialia.

[32]  Sung‐Wook Choi,et al.  Fabrication of a BMP-2-immobilized porous microsphere modified by heparin for bone tissue engineering. , 2015, Colloids and surfaces. B, Biointerfaces.

[33]  Hong Shen,et al.  Isoniazid conjugated poly(lactide-co-glycolide): long-term controlled drug release and tissue regeneration for bone tuberculosis therapy. , 2015, Biomaterials.

[34]  D. Vashaee,et al.  Significant degradability enhancement in multilayer coating of polycaprolactone-bioactive glass/gelatin-bioactive glass on magnesium scaffold for tissue engineering applications , 2015 .

[35]  Thomas J Webster,et al.  Adding MgO nanoparticles to hydroxyapatite-PLLA nanocomposites for improved bone tissue engineering applications. , 2015, Acta biomaterialia.

[36]  Ross Crawford,et al.  Osteoimmunomodulatory properties of magnesium scaffolds coated with β-tricalcium phosphate. , 2014, Biomaterials.

[37]  C. Sfeir,et al.  Role of magnesium ions on osteogenic response in bone marrow stromal cells , 2014, Connective tissue research.

[38]  Changsheng Liu,et al.  In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration. , 2014, Colloids and surfaces. B, Biointerfaces.

[39]  Wei Huang,et al.  Microsphere based scaffolds for bone regenerative applications. , 2014, Biomaterials science.

[40]  C. Sfeir,et al.  Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. , 2014, Acta biomaterialia.

[41]  Yufeng Zheng,et al.  In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants. , 2013, Biomaterials.

[42]  G. Sui,et al.  Osteocompatibility characterization of polyacrylonitrile carbon nanofibers containing bioactive glass nanoparticles , 2013 .

[43]  J. Jansen,et al.  Evaluation of bone regeneration using the rat critical size calvarial defect , 2012, Nature Protocols.

[44]  A. Rabie,et al.  The role of vascular endothelial growth factor in ossification , 2012, International Journal of Oral Science.

[45]  Jin-Woo Park,et al.  Increased new bone formation with a surface magnesium-incorporated deproteinized porcine bone substitute in rabbit calvarial defects. , 2012, Journal of biomedical materials research. Part A.

[46]  Mauro Ferrari,et al.  Mesoporous Silicon‐PLGA Composite Microspheres for the Double Controlled Release of Biomolecules for Orthopedic Tissue Engineering , 2012 .

[47]  Rozalia Dimitriou,et al.  Bone regeneration: current concepts and future directions , 2011, BMC medicine.

[48]  J. Maier,et al.  High magnesium inhibits human osteoblast differentiation in vitro. , 2011, Magnesium research.

[49]  A. Bayat,et al.  Exploring the application of mesenchymal stem cells in bone repair and regeneration. , 2011, The Journal of bone and joint surgery. British volume.

[50]  Peter X. Ma,et al.  Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair , 2011, Nature materials.

[51]  Fei Yang,et al.  An injectable scaffold: rhBMP-2-loaded poly(lactide-co-glycolide)/hydroxyapatite composite microspheres. , 2010, Acta biomaterialia.

[52]  H. Gruber,et al.  Skeletal and Hormonal Effects of Magnesium Deficiency , 2009, Journal of the American College of Nutrition.

[53]  S. Moe Disorders involving calcium, phosphorus, and magnesium. , 2008, Primary care.

[54]  Tae Gwan Park,et al.  Highly open porous biodegradable microcarriers: in vitro cultivation of chondrocytes for injectable delivery. , 2008, Tissue engineering. Part A.

[55]  Yunfeng Jiao,et al.  The co-effect of collagen and magnesium ions on calcium carbonate biomineralization , 2006 .

[56]  E. Mathiowitz,et al.  Effect of lecithin and MgCO3 as additives on the enzymatic activity of carbonic anhydrase encapsulated in poly(lactide-co-glycolide) (PLGA) microspheres. , 2002, Biochimica et biophysica acta.

[57]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[58]  A. Meunier,et al.  Tissue-engineered bone regeneration , 2000, Nature Biotechnology.

[59]  J. Sawai,et al.  Antibacterial characteristics of magnesium oxide powder , 2000 .

[60]  C. Robinson,et al.  Magnesium distribution in human bone , 1992, Calcified Tissue International.

[61]  Xudong Shi,et al.  Modification of porous PLGA microspheres by poly-l-lysine for use as tissue engineering scaffolds. , 2018, Colloids and surfaces. B, Biointerfaces.

[62]  F. Kiessling,et al.  Bone regeneration induced by a 3D architectured hydrogel in a rat critical-size calvarial defect. , 2017, Biomaterials.

[63]  Xiaohua Liu,et al.  Injectable scaffolds: Preparation and application in dental and craniofacial regeneration. , 2017, Materials science & engineering. R, Reports : a review journal.

[64]  C. Sfeir,et al.  Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction. , 2015, Acta biomaterialia.

[65]  Huipin Yuan,et al.  Zinc in calcium phosphate mediates bone induction: in vitro and in vivo model. , 2014, Acta biomaterialia.

[66]  Hong-Chen Chen,et al.  Boyden chamber assay. , 2005, Methods in molecular biology.

[67]  E. Kohn,et al.  Mg++-induced endothelial cell migration: Substratum selectivity and receptor-involvement , 2004, Angiogenesis.