Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

[1]  S. Niida,et al.  Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88 , 2017, Scientific Reports.

[2]  Perle Latré de Laté,et al.  From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home , 2017, Biomedical journal.

[3]  M. Harnett,et al.  The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ , 2016, Scientific Reports.

[4]  M. Harnett,et al.  Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES‐62 against clinically relevant allergens , 2016, Parasite immunology.

[5]  M. Harnett,et al.  The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma , 2016, Scientific Reports.

[6]  M. Harnett,et al.  Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus , 2015, Lupus.

[7]  Michael S. Lee,et al.  Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen , 2015, Scientific Reports.

[8]  J. Rebek,et al.  Structure‐Based Design and Synthesis of a Small Molecule that Exhibits Anti‐inflammatory Activity by Inhibition of MyD88‐mediated Signaling to Bacterial Toxin Exposure , 2015, Chemical biology & drug design.

[9]  M. Harnett,et al.  Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome , 2015, Journal of autoimmunity.

[10]  M. Harnett,et al.  From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis , 2015, Lupus.

[11]  M. Harnett,et al.  The Parasitic Worm Product ES-62 Targets Myeloid Differentiation Factor 88–Dependent Effector Mechanisms to Suppress Antinuclear Antibody Production and Proteinuria in MRL/lpr Mice , 2015, Arthritis & rheumatology.

[12]  M. Harnett,et al.  Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation , 2015, Experimental parasitology.

[13]  M. Harnett,et al.  The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. , 2015, International journal for parasitology.

[14]  M. Harnett,et al.  Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties , 2014, International journal for parasitology.

[15]  M. Harnett,et al.  ES‐62 Protects Against Collagen‐Induced Arthritis by Resetting Interleukin‐22 Toward Resolution of Inflammation in the Joints , 2014, Arthritis & rheumatology.

[16]  M. Harnett,et al.  ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. , 2014, Molecular and biochemical parasitology.

[17]  M. Harnett,et al.  Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints , 2014, Immunology.

[18]  Fraser J. Scott,et al.  Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis , 2013, Journal of medicinal chemistry.

[19]  E. Volpe,et al.  Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells* , 2013, The Journal of Biological Chemistry.

[20]  Xiaohui Wang,et al.  Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. , 2013, Pharmacology & therapeutics.

[21]  C. Sette,et al.  Targeting the Toll-like receptor/interleukin 1 receptor pathway in human diseases: rational design of MyD88 inhibitors. , 2013, Clinical lymphoma, myeloma & leukemia.

[22]  M. Harnett,et al.  The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype , 2013, International journal for parasitology.

[23]  W. Telford,et al.  Lipopolysaccharide induces IFN-γ production in human NK cells , 2013, Front. Immun..

[24]  M. Harnett,et al.  The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites. , 2012, Arthritis and rheumatism.

[25]  G. Ruthel,et al.  Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88 , 2012, PloS one.

[26]  W. Harnett,et al.  Immunomodulatory properties of ES-62, a phosphorylcholine-containing glycoprotein secreted by Acanthocheilonema viteae. , 2012, Endocrine, metabolic & immune disorders drug targets.

[27]  Gerhard Klebe,et al.  DSX: A Knowledge-Based Scoring Function for the Assessment of Protein-Ligand Complexes , 2011, J. Chem. Inf. Model..

[28]  G. Ruthel,et al.  MyD88-dependent pro-inflammatory cytokine response contributes to lethal toxicity of staphylococcal enterotoxin B in mice , 2011, Innate immunity.

[29]  G. Ruthel,et al.  A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice* , 2011, The Journal of Biological Chemistry.

[30]  Ghada S. Hassan,et al.  An unexpected role for MHC class II , 2011, Nature Immunology.

[31]  G. Ruthel,et al.  Activation of MyD88 Signaling upon Staphylococcal Enterotoxin Binding to MHC Class II Molecules , 2011, PloS one.

[32]  S. Fernandez,et al.  Staphylococcal enterotoxin A induction of pro‐inflammatory cytokines and lethality in mice is primarily dependent on MyD88 , 2010, Immunology.

[33]  M. Shirakawa,et al.  Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling , 2009, Proceedings of the National Academy of Sciences.

[34]  Arthur J. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[35]  Peter Natesan Pushparaj,et al.  Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes , 2007, Nature Medicine.

[36]  B. Gérard,et al.  Human neutrophils produce interferon gamma upon stimulation by interleukin-12 , 2004, Laboratory Investigation.

[37]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[38]  M. Harnett,et al.  A Novel Therapeutic Approach Targeting Articular Inflammation Using the Filarial Nematode-Derived Phosphorylcholine-Containing Glycoprotein ES-62 , 2003, The Journal of Immunology.

[39]  Ruslan Medzhitov,et al.  Toll-Like Receptor Signaling Pathways , 2003, Science.

[40]  L. O’Neill The role of MyD88-like adapters in Toll-like receptor signal transduction. , 2003, Biochemical Society transactions.

[41]  M. Grainger,et al.  Origin, kinetics of circulation and fate in vivo of the major excretory–secretory product of Acanthocheilonema viteae , 1989, Parasitology.

[42]  Peter Natesan Pushparaj,et al.  Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. , 2007, Nature medicine.

[43]  A. Ding,et al.  MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. , 2006, Nature immunology.

[44]  S. Akira,et al.  Toll-like receptors. , 2003, Annual review of immunology.