A Mobile Health Application to Predict Postpartum Depression Based on Machine Learning

Abstract Background: Postpartum depression (PPD) is a disorder that often goes undiagnosed. The development of a screening program requires considerable and careful effort, where evidence-based decisions have to be taken in order to obtain an effective test with a high level of sensitivity and an acceptable specificity that is quick to perform, easy to interpret, culturally sensitive, and cost-effective. The purpose of this article is twofold: first, to develop classification models for detecting the risk of PPD during the first week after childbirth, thus enabling early intervention; and second, to develop a mobile health (m-health) application (app) for the Android® (Google, Mountain View, CA) platform based on the model with best performance for both mothers who have just given birth and clinicians who want to monitor their patient's test. Materials and Methods: A set of predictive models for estimating the risk of PPD was trained using machine learning techniques and data about postpartum women collec...

[1]  D. Eddy Evidence-based medicine: a unified approach. , 2005, Health affairs.

[2]  L. Appleby Suicide during pregnancy and in the first postnatal year. , 1991 .

[3]  Laura V. Scaramella,et al.  Implications of Timing of Maternal Depressive Symptoms for Early Cognitive and Language Development , 2006, Clinical child and family psychology review.

[4]  K Akazawa,et al.  Accuracy in the Diagnostic Prediction of Acute Appendicitis Based on the Bayesian Network Model , 2007, Methods of Information in Medicine.

[5]  E. Paykel Methodological aspects of life events research. , 1983, Journal of psychosomatic research.

[6]  S. Marcus,et al.  Postpartum mood disorders , 2003, International review of psychiatry.

[7]  M. Gratacós,et al.  Prediction of Postpartum Depression Using Multilayer Perceptrons and Pruning , 2009, Methods of Information in Medicine.

[8]  Ray Moynihan,et al.  Court hears how drug giant Merck tried to “neutralise” and “discredit” doctors critical of Vioxx , 2009, BMJ : British Medical Journal.

[9]  J. Cox,et al.  Detection of Postnatal Depression , 1987, British Journal of Psychiatry.

[10]  H. Le,et al.  Review of screening instruments for postpartum depression , 2005, Archives of Women’s Mental Health.

[11]  Iker Gondra,et al.  Applying machine learning to software fault-proneness prediction , 2008, J. Syst. Softw..

[12]  Margaret Oates,et al.  Suicide: the leading cause of maternal death , 2003, British Journal of Psychiatry.

[13]  Tom Fawcett,et al.  An introduction to ROC analysis , 2006, Pattern Recognit. Lett..

[14]  F ROSENBLATT,et al.  The perceptron: a probabilistic model for information storage and organization in the brain. , 1958, Psychological review.

[15]  P. Cooper,et al.  Prediction, detection, and treatment of postnatal depression , 1997, Archives of disease in childhood.

[16]  L. F. García,et al.  A psychometric analysis of the revised Eysenck Personality Questionnaire short scale , 2003 .

[17]  C. Ascaso,et al.  Validation of the Edinburgh Postnatal Depression Scale (EPDS) in Spanish mothers. , 2003, Journal of affective disorders.

[18]  Timothy Masters Designing Feedforward Network Architectures , 1993 .

[19]  M. Gili,et al.  Diagnostic Interview for Genetic Studies (DIGS): Inter-rater and test-retest reliability and validity in a Spanish population , 2007, European Psychiatry.

[20]  M. Gratacós,et al.  Mood changes after delivery: role of the serotonin transporter gene , 2008, British Journal of Psychiatry.

[21]  David Goldman,et al.  Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. , 2006, The American journal of psychiatry.

[22]  J. Nurnberger,et al.  Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. , 1994, Archives of general psychiatry.