Dysregulation along the gut microbiota-immune system axis after oral exposure to titanium dioxide nanoparticles: A possible environmental factor promoting obesity-related metabolic disorders.

[1]  G. Rivière,et al.  Perinatal exposure to foodborne inorganic nanoparticles: A role in the susceptibility to food allergy? , 2022, Frontiers in Allergy.

[2]  P. Zheng,et al.  Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles , 2022, Particle and Fibre Toxicology.

[3]  Jiao Guo,et al.  The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity , 2022, Frontiers in Nutrition.

[4]  Marlon J. A. Jetten,et al.  The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer , 2022, Nanomaterials.

[5]  J. Rhim,et al.  Titanium dioxide (TiO2) for the manufacture of multifunctional active food packaging films , 2022, Food Packaging and Shelf Life.

[6]  A. Gazzaniga,et al.  What's next in the use of opacifiers for cosmetic coatings of solid dosage forms? Insights on current titanium dioxide alternatives. , 2022, International journal of pharmaceutics.

[7]  C. Pheiffer,et al.  Intestinal Barrier Function and Immune Homeostasis Are Missing Links in Obesity and Type 2 Diabetes Development , 2022, Frontiers in Endocrinology.

[8]  M. Carrière,et al.  Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer , 2021, Particle and fibre toxicology.

[9]  Rex E FitzGerald,et al.  Safety assessment of titanium dioxide (E171) as a food additive , 2021, EFSA journal. European Food Safety Authority.

[10]  Hengyi Xu,et al.  Foodborne TiO2 Nanoparticles Induced More Severe Hepatotoxicity in Fructose-Induced Metabolic Syndrome Mice via Exacerbating Oxidative Stress-Mediated Intestinal Barrier Damage , 2021, Foods.

[11]  P. Oleszczuk,et al.  Four Types of TiO2 Reduced the Growth of Selected Lactic Acid Bacteria Strains , 2021, Foods.

[12]  Yongliang Zhang,et al.  The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs , 2021, Particle and fibre toxicology.

[13]  M. Touvier,et al.  Ultra-processed foods and human health: What do we already know and what will further research tell us? , 2021, EClinicalMedicine.

[14]  H. van Loveren,et al.  Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System , 2020, International journal of molecular sciences.

[15]  M. Nieuwdorp,et al.  Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes , 2020, Frontiers in Immunology.

[16]  J. Pedraza-Chaverri,et al.  Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat diet model. , 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[17]  V. Gayrard,et al.  Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model , 2020, Particle and Fibre Toxicology.

[18]  Nisha Padmanabhan,et al.  Titanium dioxide based self-cleaning smart surfaces: A short review , 2020 .

[19]  Yongliang Zhang,et al.  Effects of titanium dioxide nanoparticles on nutrient absorption and metabolism in rats: distinguishing the susceptibility of amino acids, metal elements, and glucose , 2020, Nanotoxicology.

[20]  V. Théodorou,et al.  Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice , 2020, Particle and Fibre Toxicology.

[21]  Hang Xiao,et al.  Foodborne Titanium Dioxide Nanoparticles Induce Stronger Adverse Effects in Obese Mice than Non-Obese Mice: Gut Microbiota Dysbiosis, Colonic Inflammation, and Proteome Alterations. , 2020, Small.

[22]  E. Houdeau,et al.  Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health , 2020, Particle and Fibre Toxicology.

[23]  K. Clément,et al.  AhR activation defends gut barrier integrity against damage occurring in obesity , 2020, Molecular metabolism.

[24]  R. Rodrigues,et al.  Role of gut microbiota in type 2 diabetes pathophysiology , 2020, EBioMedicine.

[25]  G. Jia,et al.  Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles , 2019, Particle and Fibre Toxicology.

[26]  Jing Liu,et al.  The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice , 2019, Environmental toxicology.

[27]  Samuel M. Cohen,et al.  Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2). , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[28]  S. Taleb.  Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases , 2019, Front. Immunol..

[29]  A. Fujishima,et al.  Applications of photocatalytic titanium dioxide-based nanomaterials in sustainable agriculture , 2019, Journal of Photochemistry and Photobiology C: Photochemistry Reviews.

[30]  A. Raggi,et al.  Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status , 2019, Nanotoxicology.

[31]  P. Møller,et al.  Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles. , 2019, Mutagenesis.

[32]  Robert J. Moore,et al.  Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction , 2019, Front. Nutr..

[33]  N. Herlin‐Boime,et al.  The food additive E171 and titanium dioxide nanoparticles indirectly alter the homeostasis of human intestinal epithelial cells in vitro , 2019, Environmental Science: Nano.

[34]  F. Tinahones,et al.  Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases , 2019, Front. Nutr..

[35]  F. Quintana,et al.  The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease , 2019, Nature Reviews Immunology.

[36]  Ayushi Priyam,et al.  Role of Endocrine-Disrupting Engineered Nanomaterials in the Pathogenesis of Type 2 Diabetes Mellitus , 2018, Front. Endocrinol..

[37]  R. Xavier,et al.  Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome. , 2018, Cell metabolism.

[38]  Jared M Brown,et al.  Immune responses to engineered nanomaterials: current understanding and challenges. , 2018, Current opinion in toxicology.

[39]  S. More,et al.  Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health , 2018, EFSA journal. European Food Safety Authority.

[40]  Julie Rodriguez,et al.  The gut microbiota metabolite indole alleviates liver inflammation in mice , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  X. Coumoul,et al.  AhR signaling pathways and regulatory functions , 2018, Biochimie open.

[42]  Harry Sokol,et al.  Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. , 2018, Cell host & microbe.

[43]  A. Heller,et al.  Association of Type 2 Diabetes with Submicron Titanium Dioxide Crystals in the Pancreas. , 2018, Chemical research in toxicology.

[44]  Ya-nan Chang,et al.  Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure. , 2018, Nanoscale.

[45]  C. Cartier,et al.  Toxicity of Food-Grade TiO2 to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging , 2018, Front. Microbiol..

[46]  H. Bouwmeester,et al.  Detection of titanium particles in human liver and spleen and possible health implications , 2018, Particle and Fibre Toxicology.

[47]  H. Sokol,et al.  Aryl hydrocarbon receptor and intestinal immunity , 2018, Mucosal Immunology.

[48]  S. Charles,et al.  Assessment of the in vitro genotoxicity of TiO2 nanoparticles in a regulatory context , 2018, Nanotoxicology.

[49]  J. Cleveland,et al.  Role of Polyamines in Immune Cell Functions , 2018, Medical sciences.

[50]  Marta G. Vučković,et al.  Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism , 2018, Diabetes.

[51]  P. Nighot,et al.  Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression. , 2017, The American journal of pathology.

[52]  A. Gasbarrini,et al.  Proteobacteria: A Common Factor in Human Diseases , 2017, BioMed research international.

[53]  Valeria De Matteis,et al.  Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation , 2017, Toxics.

[54]  M. Wang,et al.  The effects of orally administered Ag, TiO 2 and SiO 2 nanoparticles on gut microbiota composition and colitis induction in mice , 2017 .

[55]  P. Sansonetti,et al.  Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity. , 2017, Biochimie.

[56]  N. Hacohen,et al.  Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages. , 2017, Immunity.

[57]  P. Gérard,et al.  Microbiota, Liver Diseases, and Alcohol. , 2017, Microbiology spectrum.

[58]  C. Lebrilla,et al.  Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion , 2017, Science.

[59]  M. Chamaillard,et al.  Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence , 2017, Gut.

[60]  E. Allen-Vercoe,et al.  Impact of food grade and nano-TiO2 particles on a human intestinal community. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[61]  N. Herlin‐Boime,et al.  Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress , 2017, Nanotoxicology.

[62]  Sarah A. Hansen,et al.  Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles , 2017, Scientific Reports.

[63]  P. Langella,et al.  Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria , 2017, Microbial Cell Factories.

[64]  Manuela Semmler-Behnke,et al.  Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2 , 2017, Nanotoxicology.

[65]  M. Fafutis-Morris,et al.  Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview , 2017, Front. Immunol..

[66]  V. Azevedo,et al.  Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-κB Pathway , 2017, Front. Microbiol..

[67]  Elisa Boutet-Robinet,et al.  Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon , 2017, Scientific Reports.

[68]  T. Dinan,et al.  Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration , 2017, The Journal of physiology.

[69]  Gretchen J. Mahler,et al.  Titanium Dioxide Nanoparticle Ingestion Alters Nutrient Absorption in an In Vitro Model of the Small Intestine. , 2017, NanoImpact.

[70]  Hae Ung Lee,et al.  Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system , 2016, Journal of Molecular Medicine.

[71]  M. Adeva-Andany,et al.  Liver glucose metabolism in humans , 2016, Bioscience reports.

[72]  Patrice D Cani,et al.  Human Intestinal Barrier Function in Health and Disease , 2016, Clinical and Translational Gastroenterology.

[73]  Yujie Feng,et al.  A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice. , 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[74]  E. Elinav,et al.  Metabolites: messengers between the microbiota and the immune system , 2016, Genes & development.

[75]  W. Garrett,et al.  Gut microbiota, metabolites and host immunity , 2016, Nature Reviews Immunology.

[76]  R. Xavier,et al.  CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands , 2016, Nature Medicine.

[77]  E. Seifried,et al.  Spleen Size Is Significantly Influenced by Body Height and Sex: Establishment of Normal Values for Spleen Size at US with a Cohort of 1200 Healthy Individuals. , 2016, Radiology.

[78]  Renan Corrêa-Oliveira,et al.  Regulation of immune cell function by short-chain fatty acids , 2016, Clinical & translational immunology.

[79]  H. Ohno.  Intestinal M cells. , 2016, Journal of biochemistry.

[80]  J. Cryan,et al.  Gut Microbiota and Brain Function: An Evolving Field in Neuroscience , 2015, The international journal of neuropsychopharmacology.

[81]  Liang Zhou.  AHR Function in Lymphocytes: Emerging Concepts. , 2016, Trends in immunology.

[82]  Lin Zhao,et al.  Interaction of titanium dioxide nanoparticles with glucose on young rats after oral administration. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[83]  Yujie Feng,et al.  Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species‐induced insulin resistance in mice , 2015, Journal of applied toxicology : JAT.

[84]  J. Powell,et al.  Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers , 2015, Particle and Fibre Toxicology.

[85]  Na-Ri Shin,et al.  Proteobacteria: microbial signature of dysbiosis in gut microbiota. , 2015, Trends in biotechnology.

[86]  Y. Bhutia,et al.  Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. , 2015, The Biochemical journal.

[87]  Ian M. Marcus,et al.  Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota , 2015 .

[88]  D. Kasper,et al.  A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39+Foxp3+ T cells and Treg function , 2015, Gut microbes.

[89]  H. Sokol,et al.  Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease , 2015, Gut.

[90]  B. Schnabl,et al.  The Gut Microbiota and Liver Disease , 2015, Cellular and molecular gastroenterology and hepatology.

[91]  M Dorier,et al.  Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells. , 2015, Nanoscale.

[92]  Kate Jones,et al.  Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles. , 2015, Toxicology letters.

[93]  D. Brenner,et al.  Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[94]  Max Nieuwdorp,et al.  Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes , 2014, Diabetes Care.

[95]  R. Ley,et al.  Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. , 2014, Gastroenterology.

[96]  J. Fechner,et al.  The Aryl Hydrocarbon Receptor Meets Immunology: Friend or Foe? A Little of Both , 2014, Front. Immunol..

[97]  M. Fei,et al.  Immunomodulatory effects in the spleen-injured mice following exposure to titanium dioxide nanoparticles. , 2014, Journal of biomedical materials research. Part A.

[98]  T. Weir,et al.  Diet and the development of the human intestinal microbiome , 2014, Front. Microbiol..

[99]  D. Passeri,et al.  Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen , 2014, Nanotoxicology.

[100]  W. Ouyang,et al.  Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes , 2014, Nature.

[101]  Anthony A. Fodor,et al.  Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer , 2014, Nature Communications.

[102]  G. Janer,et al.  Cell uptake and oral absorption of titanium dioxide nanoparticles. , 2014, Toxicology letters.

[103]  H. Bouwmeester,et al.  Characterization of titanium dioxide nanoparticles in food products: analytical methods to define nanoparticles. , 2014, Journal of agricultural and food chemistry.

[104]  P. Herckes,et al.  Characterization of food-grade titanium dioxide: the presence of nanosized particles. , 2014, Environmental science & technology.

[105]  J. Faust,et al.  Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation , 2014, Cell Biology and Toxicology.

[106]  D. Moore,et al.  All‐trans‐retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade , 2014, Hepatology.

[107]  F. T. ten Kate,et al.  Exogenous Pigment in Peyer Patches of Children Suspected of Having IBD , 2014, Journal of pediatric gastroenterology and nutrition.

[108]  B. Stockinger,et al.  The aryl hydrocarbon receptor: multitasking in the immune system. , 2014, Annual review of immunology.

[109]  A. Keshavarzian,et al.  Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics , 2014, Front. Immunol..

[110]  Y. Sanz,et al.  Microbiota, inflammation and obesity. , 2014, Advances in experimental medicine and biology.

[111]  N. Herlin‐Boime,et al.  Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia , 2014, Particle and Fibre Toxicology.

[112]  A. Astrup,et al.  Is butyrate the link between diet, intestinal microbiota and obesity‐related metabolic diseases? , 2013, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[113]  E. Zoetendal,et al.  Human intestinal microbiota composition is associated with local and systemic inflammation in obesity , 2013, Obesity.

[114]  P. Bork,et al.  Richness of human gut microbiome correlates with metabolic markers , 2013, Nature.

[115]  Intawat Nookaew,et al.  Understanding the interactions between bacteria in the human gut through metabolic modeling , 2013, Scientific Reports.

[116]  A. De Luca,et al.  Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. , 2013, Immunity.

[117]  X. Coumoul,et al.  The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. , 2013, Drug discovery today.

[118]  Sang-Uk Seo,et al.  Role of the gut microbiota in immunity and inflammatory disease , 2013, Nature Reviews Immunology.

[119]  F. Bäckhed,et al.  The gut microbiota — masters of host development and physiology , 2013, Nature Reviews Microbiology.

[120]  H. Said,et al.  Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. , 2013, The American journal of pathology.

[121]  Liping Zhao,et al.  An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice , 2012, The ISME Journal.

[122]  Belgin Dogan,et al.  Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota , 2012, Science.

[123]  E. Zoetendal,et al.  Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. , 2012, Gastroenterology.

[124]  K. Shudo,et al.  Retinoids ameliorate insulin resistance in a leptin‐dependent manner in mice , 2012, Hepatology.

[125]  S. Toma,et al.  Titanium dioxide induced inflammation in the small intestine. , 2012, World journal of gastroenterology.

[126]  William A. Walters,et al.  Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. , 2012, Cell host & microbe.

[127]  David A. Relman,et al.  Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota , 2012, Cell.

[128]  B. Han,et al.  Risk Assessment Principle for Engineered Nanotechnology in Food and Drug , 2012, Toxicological research.

[129]  Katherine H. Huang,et al.  Structure, Function and Diversity of the Healthy Human Microbiome , 2012, Nature.

[130]  Hua V. Lin,et al.  Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms , 2012, PloS one.

[131]  Na Li,et al.  The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles. , 2012, Journal of biomedical materials research. Part A.

[132]  P. Westerhoff,et al.  Titanium dioxide nanoparticles in food and personal care products. , 2012, Environmental science & technology.

[133]  G. Major,et al.  Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? , 2012, Journal of obesity.

[134]  M. Veldhoen,et al.  Epithelial barrier biology: good fences make good neighbours , 2012, Immunology.

[135]  Liping Zhao,et al.  Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers , 2011, The ISME Journal.

[136]  D. Bumann,et al.  Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota , 2011, PloS one.

[137]  Wei Sun,et al.  The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. , 2011, Cell metabolism.

[138]  D. Artis,et al.  Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22 , 2011, Nature Immunology.

[139]  Jun Yang,et al.  Synthesis of Ag–TiO2 composite nano thin film for antimicrobial application , 2011, Nanotechnology.

[140]  F. Hong,et al.  Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. , 2010, Journal of hazardous materials.

[141]  Maria Karlsson,et al.  Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. , 2010, Cell host & microbe.

[142]  S. Mazmanian,et al.  Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota , 2010, Proceedings of the National Academy of Sciences.

[143]  R. Ley,et al.  Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 , 2010, Science.

[144]  P. Bork,et al.  A human gut microbial gene catalogue established by metagenomic sequencing , 2010, Nature.

[145]  Joseph M Betz,et al.  Nanotechnology research: applications in nutritional sciences. , 2010, The Journal of nutrition.

[146]  Dan R. Littman,et al.  Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria , 2009, Cell.

[147]  Annaïg Lan,et al.  The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. , 2009, Immunity.

[148]  M. Neurath,et al.  STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing , 2009, The Journal of experimental medicine.

[149]  J. Doré,et al.  The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age , 2009, BMC Microbiology.

[150]  T. Xia,et al.  Potential health impact of nanoparticles. , 2009, Annual review of public health.

[151]  J. Doré,et al.  Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients , 2008, Proceedings of the National Academy of Sciences.

[152]  T. Lebien,et al.  B lymphocytes: how they develop and function. , 2008, Blood.

[153]  H. Weiner,et al.  Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor , 2008, Nature.

[154]  Q. Chaudhry,et al.  Applications and implications of nanotechnologies for the food sector , 2008, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[155]  Wendy S. Garrett,et al.  Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System , 2007, Cell.

[156]  M. Maden.  Retinoic acid in the development, regeneration and maintenance of the nervous system , 2007, Nature Reviews Neuroscience.

[157]  R. Noelle,et al.  All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation , 2007, The Journal of experimental medicine.

[158]  Y. Belkaid,et al.  A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism , 2007, The Journal of experimental medicine.

[159]  Hilde Cheroutre,et al.  Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid , 2007, Science.

[160]  K. McCoy,et al.  Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. , 2007, Seminars in immunology.

[161]  P. Turnbaugh,et al.  Microbial ecology: Human gut microbes associated with obesity , 2006, Nature.

[162]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[163]  M. Pop,et al.  Metagenomic Analysis of the Human Distal Gut Microbiome , 2006, Science.

[164]  M. Comalada,et al.  The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype , 2006, Journal of Cancer Research and Clinical Oncology.

[165]  F. Gage,et al.  Retinoic acid is required early during adult neurogenesis in the dentate gyrus. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[166]  R. D. de Souza,et al.  Colonic Health: Fermentation and Short Chain Fatty Acids , 2006, Journal of clinical gastroenterology.

[167]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[168]  J. Preiß,et al.  Adverse Health Effects in Humans Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) , 2006, Reviews on environmental health.

[169]  T. Wilczok,et al.  Butyrate-Induced Differentiation of Colon Cancer Cells Is PKC and JNK Dependent , 2005, Digestive Diseases and Sciences.

[170]  A. Macpherson,et al.  Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria , 2004, Science.

[171]  Antonietta M Gatti,et al.  Biocompatibility of micro- and nano-particles in the colon. Part II. , 2004, Biomaterials.

[172]  R. Kedzierski,et al.  Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[173]  Yoshito Tsushima,et al.  Spleen Enlargement in Patients with Nonalcoholic Fatty Liver , 2004, Digestive Diseases and Sciences.

[174]  S. Fleming,et al.  Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells. , 2003, The Journal of nutrition.

[175]  J. Shaw,et al.  Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[176]  A. Dhillon,et al.  Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue. , 1996, Gut.