Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
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[1] A. Ben-Ze'ev. Faculty Opinions recommendation of Epithelial-to-mesenchymal transition in cancer: complexity and opportunities. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[2] T. Voet,et al. Identification of the tumour transition states occurring during EMT , 2018, Nature.
[3] A. Shaw,et al. Tumour heterogeneity and resistance to cancer therapies , 2018, Nature Reviews Clinical Oncology.
[4] Shawn M. Gillespie,et al. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.
[5] R. Weinberg,et al. Upholding a role for EMT in pancreatic cancer metastasis , 2017, Nature.
[6] Jill P. Mesirov,et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway , 2017, Nature.
[7] Stuart L. Schreiber,et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition , 2017, Nature.
[8] J. Thiery,et al. New insights into the role of EMT in tumor immune escape , 2017, Molecular oncology.
[9] C. Pilarsky,et al. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer , 2017, Nature Cell Biology.
[10] R. Weinberg,et al. EMT, CSCs, and drug resistance: the mechanistic link and clinical implications , 2017, Nature Reviews Clinical Oncology.
[11] R. Weinberg,et al. Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas. , 2017, Cancer research.
[12] R. Weinberg,et al. Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells , 2017, Proceedings of the National Academy of Sciences.
[13] R. Weinberg,et al. Emerging Biological Principles of Metastasis , 2017, Cell.
[14] Henry W. Long,et al. Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance , 2017, Science.
[15] M. Rubin,et al. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer , 2017, Science.
[16] T. Tan,et al. The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200 , 2017, Oncoimmunology.
[17] L. Byers,et al. A phase I/II and pharmacokinetic study of BGB324, a selective AXL inhibitor as monotherapy and in combination with erlotinib in patients with advanced non-small cell lung cancer (NSCLC) , 2016 .
[18] Paul Martin,et al. Wound repair: a showcase for cell plasticity and migration. , 2016, Current opinion in cell biology.
[19] Robert A. Weinberg,et al. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability , 2016, Science.
[20] James E. Verdone,et al. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters , 2016, Proceedings of the National Academy of Sciences.
[21] M. Miyazaki,et al. Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization , 2016, Genes & development.
[22] G. Getz,et al. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition , 2016, Nature Medicine.
[23] Erik Sahai,et al. Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization , 2015, Cell reports.
[24] V. LeBleu,et al. EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer , 2015, Nature.
[25] R. Weinberg,et al. Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression. , 2015, Trends in cell biology.
[26] Chih-Yang Wang,et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells , 2015, Nature.
[27] Jennifer M. Carr,et al. Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity , 2015, Nature Cell Biology.
[28] Michael B. Stadler,et al. PIK3CAH1047R induces multipotency and multi-lineage mammary tumours , 2015, Nature.
[29] S. Estrem,et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway , 2015, Drug design, development and therapy.
[30] R. Weinberg,et al. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells , 2015, Nature.
[31] Yunyun Zhou,et al. An epigenetically distinct breast cancer cell subpopulation promotes collective invasion. , 2015, The Journal of clinical investigation.
[32] Joshua M. Korn,et al. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding , 2015, Nature Medicine.
[33] Andreas W. Schreiber,et al. The RNA Binding Protein Quaking Regulates Formation of circRNAs , 2015, Cell.
[34] Zhiqing Liang,et al. CD133+ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition , 2015, Oncotarget.
[35] Lixia Diao,et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumor cell PD-L1 expression and intratumoral immunosuppression , 2014, Nature Communications.
[36] S. Carr,et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages , 2014, Nature Cell Biology.
[37] Sridhar Ramaswamy,et al. Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis , 2014, Cell.
[38] R. Weinberg,et al. Tackling the cancer stem cells — what challenges do they pose? , 2014, Nature Reviews Drug Discovery.
[39] K. Tsang,et al. WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition. , 2014, Cancer research.
[40] Bogi Andersen,et al. Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. , 2014, Developmental cell.
[41] G. Christofori,et al. The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion , 2014, Oncogene.
[42] Samy Lamouille,et al. Molecular mechanisms of epithelial–mesenchymal transition , 2014, Nature Reviews Molecular Cell Biology.
[43] D. Quail,et al. Microenvironmental regulation of tumor progression and metastasis , 2014 .
[44] Jing Yang,et al. Epithelial–mesenchymal plasticity in carcinoma metastasis , 2013, Genes & development.
[45] C. Klein. Selection and adaptation during metastatic cancer progression , 2013, Nature.
[46] N. McGranahan,et al. The causes and consequences of genetic heterogeneity in cancer evolution , 2013, Nature.
[47] Corbin E. Meacham,et al. Tumour heterogeneity and cancer cell plasticity , 2013, Nature.
[48] C. Sheridan. First Axl inhibitor enters clinical trials , 2013, Nature Biotechnology.
[49] Robert A. Weinberg,et al. Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity , 2013, Cell.
[50] G. Pan,et al. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming , 2013, Nature Cell Biology.
[51] T. Tan,et al. Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. , 2013, Cancer research.
[52] Sridhar Ramaswamy,et al. Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition , 2013, Science.
[53] Jing Yang,et al. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. , 2012, Cancer cell.
[54] M. Nieto,et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. , 2012, Cancer cell.
[55] Michael Peyton,et al. An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance , 2012, Clinical Cancer Research.
[56] Jean Paul Thiery,et al. Epithelial-mesenchymal transitions: insights from development , 2012, Development.
[57] Bruce G. Haffty,et al. Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug , 2012, Nature Cell Biology.
[58] R. Weinberg,et al. Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. , 2012, Cancer discovery.
[59] P. Friedl,et al. Classifying collective cancer cell invasion , 2012, Nature Cell Biology.
[60] Ling Xia,et al. Overexpression of Snail induces epithelial–mesenchymal transition and a cancer stem cell–like phenotype in human colorectal cancer cells , 2012, Cancer medicine.
[61] B. Cieply,et al. Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2. , 2012, Cancer research.
[62] P. A. Futreal,et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. , 2012, The New England journal of medicine.
[63] Wenjun Guo,et al. Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State , 2012, Cell.
[64] Maximilian Reichert,et al. EMT and Dissemination Precede Pancreatic Tumor Formation , 2012, Cell.
[65] A. Menssen,et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions , 2011, Cell cycle.
[66] Nicholas C. Flytzanis,et al. An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype , 2011, PLoS genetics.
[67] A. Rangarajan,et al. Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters , 2011, Cell Death and Disease.
[68] Jun Qin,et al. Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness. , 2011, Cancer research.
[69] Paul A. Wiggins,et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state , 2011, Proceedings of the National Academy of Sciences.
[70] M. Hung,et al. p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulating miRNAs , 2010, Nature Cell Biology.
[71] Zhiwei Wang,et al. Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells , 2010, PloS one.
[72] B. Zhou,et al. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1 , 2010, The EMBO journal.
[73] C. Iacobuzio-Donahue,et al. Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. , 2010, Journal of the National Cancer Institute.
[74] Bjørn Tore Gjertsen,et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival , 2009, Proceedings of the National Academy of Sciences.
[75] R. Huang,et al. Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.
[76] S. Morrison,et al. Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution , 2009, Cell.
[77] D. Gilmour,et al. EMT 2.0: shaping epithelia through collective migration. , 2009, Current opinion in genetics & development.
[78] P. Friedl,et al. Collective cell migration in morphogenesis, regeneration and cancer , 2009, Nature Reviews Molecular Cell Biology.
[79] S. Krauss,et al. Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma , 2009, Clinical & Experimental Metastasis.
[80] R. Weinberg,et al. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.
[81] Claude C. Warzecha,et al. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. , 2009, Molecular cell.
[82] Yutaka Kawakami,et al. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. , 2009, Cancer cell.
[83] Samy Lamouille,et al. TGF-β-induced epithelial to mesenchymal transition , 2009, Cell Research.
[84] A. Puisieux,et al. Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition , 2008, PloS one.
[85] K. Helin,et al. Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor , 2008, Molecular and Cellular Biology.
[86] M. Korpal,et al. The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2* , 2008, Journal of Biological Chemistry.
[87] Wenjun Guo,et al. The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.
[88] G. Goodall,et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.
[89] Sun-Mi Park,et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. , 2008, Genes & development.
[90] R. Eils,et al. Systemic spread is an early step in breast cancer. , 2008, Cancer cell.
[91] J. Aguirre-Ghiso,et al. Models, mechanisms and clinical evidence for cancer dormancy , 2007, Nature Reviews Cancer.
[92] Héctor Peinado,et al. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? , 2007, Nature Reviews Cancer.
[93] A. Puisieux,et al. Metastasis: a question of life or death , 2006, Nature Reviews Cancer.
[94] Thomas Kirchner,et al. Migrating cancer stem cells — an integrated concept of malignant tumour progression , 2005, Nature Reviews Cancer.
[95] T. Fehm,et al. A pooled analysis of bone marrow micrometastasis in breast cancer. , 2005, The New England journal of medicine.
[96] Tanja Fehm,et al. Circulating Tumor Cells in Patients with Breast Cancer Dormancy , 2004, Clinical Cancer Research.
[97] M. Hung,et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition , 2004, Nature Cell Biology.
[98] S. Ramaswamy,et al. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.
[99] I. Fabregat,et al. Snail blocks the cell cycle and confers resistance to cell death. , 2004, Genes & development.
[100] H. Moses,et al. Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro , 2004, Breast Cancer Research.
[101] E. Ballestar,et al. Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex , 2004, Molecular and Cellular Biology.
[102] L. Nelles,et al. Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. , 2003, American journal of human genetics.
[103] J. Thiery. Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.
[104] G. Naumov,et al. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. , 2002, Cancer research.
[105] E. Carver,et al. The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition , 2001, Molecular and Cellular Biology.
[106] J. Sundberg,et al. The Slug gene is not essential for mesoderm or neural crest development in mice. , 1998, Developmental biology.
[107] H. Kikutani,et al. Impairment of T Cell Development in δ EF1 Mutant Mice , 1997, The Journal of experimental medicine.
[108] G. Berx,et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. , 1996, Oncogene.
[109] S. Barsky,et al. Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. , 1996, The American journal of surgical pathology.
[110] H. Allgayer,et al. Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer , 1995, Nature Medicine.
[111] R. Behringer,et al. twist is required in head mesenchyme for cranial neural tube morphogenesis. , 1995, Genes & development.
[112] E. Hay,et al. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells , 1982, The Journal of cell biology.
[113] Jean Paul Thiery,et al. EMT: 2016 , 2016, Cell.
[114] Hollis G. Potter,et al. Author Manuscript , 2013 .