论文信息 - SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 2-(2'-SUBSTITUTED - BENZYLIDENE - HYDRAZINO -ACETYL) - MERCAPTO -5-METHYL - 1, 3, 4- THIADIAZOLES AND 2 -(2'- {4 - SUBSTITUTED -ARYL - 3 - CHLORO - 2 - OXO -AZETIDINE } -ACETYL-AMINO-

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 2-(2'-SUBSTITUTED - BENZYLIDENE - HYDRAZINO -ACETYL) - MERCAPTO -5-METHYL - 1, 3, 4- THIADIAZOLES AND 2 -(2'- {4 - SUBSTITUTED -ARYL - 3 - CHLORO - 2 - OXO -AZETIDINE } -ACETYL-AMINO-

As a part of systematic investigation of synthesis and biological activity of several new 2-(2'-substi tutedbenzylidene-hydrazino-acetyl)-mercapto-5-methyl-1,3,4-thiadiazoles, 3(a-n) and 2-[2'-{4-substituted-aryl-3chloro-2-oxo-azetidine}-acetyl-amino-mercapto]-5-methyl-1,3,4-thiadiazoles, 4(a-n) have been synthesized from 2-(2'-hydrazino-acetyl)-mercapto-5-methyl-1,3,4-thiadiazoles, 2 using 5-methyl-1,3,4-thiadiazole-2thiol as the starting material. All the synthesized products were evaluated for their antibacterial ac tivity against Bacillus substilis, Escherichia coli. Klebsiella pn eumoniae and Streptococcus aureus bacteria and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxi sporium and Trichoderma viride fungi respectively. The structures of all the synth esized compounds have been determined by their spectral and microanalytical data.

H. Gour

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