Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer

[1]  T. Walz,et al.  Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase , 2014, Nature.

[2]  H. Holden,et al.  The enzymes of biotin dependent CO2 metabolism: What structures reveal about their reaction mechanisms , 2012, Protein science : a publication of the Protein Society.

[3]  L. Tong,et al.  Structure and function of biotin-dependent carboxylases , 2012, Cellular and Molecular Life Sciences.

[4]  L. Tong,et al.  Crystal Structure of Urea Carboxylase Provides Insights into the Carboxyltransfer Reaction* , 2012, The Journal of Biological Chemistry.

[5]  G. Booker,et al.  Structure, function and selective inhibition of bacterial acetyl-coa carboxylase , 2011, Applied Microbiology and Biotechnology.

[6]  Z. Zhou,et al.  An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase , 2011 .

[7]  Z. Zhou,et al.  An unanticipated architecture of the 750 kD holoenzyme of 3-methylcrotonyl-CoA carboxylase , 2011, Nature.

[8]  J. Cronan,et al.  Dimerization of the Bacterial Biotin Carboxylase Subunit Is Required for Acetyl Coenzyme A Carboxylase Activity In Vivo , 2011, Journal of bacteriology.

[9]  H. Abramson.  The lipogenesis pathway as a cancer target. , 2011, Journal of medicinal chemistry.

[10]  L. Tong,et al.  Structural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and Dimerization* , 2011, The Journal of Biological Chemistry.

[11]  Z. Zhou,et al.  Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase , 2010, Nature.

[12]  B. Wang,et al.  Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase. , 2009, Bioorganic & medicinal chemistry letters.

[13]  C. Chou,et al.  Crystal Structure of Biotin Carboxylase in Complex with Substrates and Implications for Its Catalytic Mechanism* , 2009, Journal of Biological Chemistry.

[14]  Liisa Holm,et al.  Searching protein structure databases with DaliLite v.3 , 2008, Bioinform..

[15]  Liang Tong,et al.  Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction , 2008, Nature Structural &Molecular Biology.

[16]  I. Rayment,et al.  Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme , 2007, Science.

[17]  Randy J. Read,et al.  Phaser crystallographic software , 2007, Journal of applied crystallography.

[18]  Jenn-Kang Hwang,et al.  Crystal Structure of Helicobacter pylori Formamidase AmiF Reveals a Cysteine-Glutamate-Lysine Catalytic Triad* , 2007, Journal of Biological Chemistry.

[19]  L. Tong,et al.  Is dimerization required for the catalytic activity of bacterial biotin carboxylase? , 2006, Molecular cell.

[20]  Liang Tong,et al.  A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. , 2004, Molecular cell.

[21]  L. Tong,et al.  Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186. , 2004, Structure.

[22]  S. Volrath,et al.  Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain. , 2004, The Biochemical journal.

[23]  D. Hargrove,et al.  Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals* , 2003, Journal of Biological Chemistry.

[24]  Liang Tong,et al.  Crystal Structure of the Carboxyltransferase Domain of Acetyl-Coenzyme A Carboxylase , 2003, Science.

[25]  Grover L Waldrop,et al.  Multi-subunit acetyl-CoA carboxylases. , 2002, Progress in lipid research.

[26]  A. Chapman-Smith,et al.  Stabilization of the Biotinoyl Domain of Escherichia coli Acetyl-CoA Carboxylase by Interactions between the Attached Biotin and the Protruding “Thumb” Structure* , 2002, The Journal of Biological Chemistry.

[27]  Patrice Gouet,et al.  ESPript: analysis of multiple sequence alignments in PostScript , 1999, Bioinform..

[28]  G. Waldrop,et al.  Mutations at four active site residues of biotin carboxylase abolish substrate-induced synergism by biotin. , 1999, Biochemistry.

[29]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[30]  E. Schweizer,et al.  Pleiotropic phenotype of acetyl-CoA-carboxylase-defective yeast cells--viability of a BPL1-amber mutation depending on its readthrough by normal tRNA(Gln)(CAG). , 1998, European journal of biochemistry.

[31]  A. Chapman-Smith,et al.  Covalent Modification of an Exposed Surface Turn Alters the Global Conformation of the Biotin Carrier Domain of Escherichia coli Acetyl-CoA Carboxylase* , 1997, The Journal of Biological Chemistry.

[32]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[33]  R. Schneiter,et al.  A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex , 1996, Molecular and cellular biology.

[34]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[35]  H M Holden,et al.  Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase. , 1994, Biochemistry.

[36]  Hyun-soo Cho,et al.  Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. , 2010, Biochemical and biophysical research communications.

[37]  Thomas C Terwilliger,et al.  SOLVE and RESOLVE: automated structure solution and density modification. , 2003, Methods in enzymology.

[38]  Bernhard Rupp,et al.  Correspondence e-mail: , 2000 .

[39]  Z. Otwinowski,et al.  Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[40]  Randy J Read,et al.  Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination , 2022 .