Delayed mammary gland involution in MMTV-AKT1 transgenic mice

[1]  S. Anderson,et al.  Mammary gland involution is delayed by activated Akt in transgenic mice. , 2001, Molecular endocrinology.

[2]  R. Cardiff,et al.  Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression , 2001, Molecular and Cellular Biology.

[3]  M. Birnbaum,et al.  Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation* , 2000, The Journal of Biological Chemistry.

[4]  D. Yee,et al.  Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells , 2000, Oncogene.

[5]  I. H. Hamelers,et al.  Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells. , 2000, The Journal of endocrinology.

[6]  E. Rosen,et al.  Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways. , 2000, Cancer research.

[7]  N. Ferrara,et al.  A repressor sequence in the juxtamembrane domain of Flt‐1 (VEGFR‐1) constitutively inhibits vascular endothelial growth factor‐dependent phosphatidylinositol 3′‐kinase activation and endothelial cell migration , 2000, The EMBO journal.

[8]  Monilola A. Olayioye,et al.  The ErbB signaling network: receptor heterodimerization in development and cancer , 2000, The EMBO journal.

[9]  S R Datta,et al.  14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. , 2000, Molecular cell.

[10]  E. Schmidt,et al.  The Oncoprotein Kinase Chaperone CDC37 Functions as an Oncogene in Mice and Collaborates with Both c-mycand Cyclin D1 in Transformation of Multiple Tissues , 2000, Molecular and Cellular Biology.

[11]  N. Holbrook,et al.  Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival* , 2000, The Journal of Biological Chemistry.

[12]  K. Heidenreich,et al.  Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein* , 2000, The Journal of Biological Chemistry.

[13]  A. Newton,et al.  Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site* , 2000, The Journal of Biological Chemistry.

[14]  M. Hung,et al.  HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB Pathway* , 2000, The Journal of Biological Chemistry.

[15]  K. Helin,et al.  The E2F transcription factors: key regulators of cell proliferation. , 2000, Biochimica et biophysica acta.

[16]  L. Peso,et al.  Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt , 1999, Oncogene.

[17]  G. Mills,et al.  The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells , 1999, Oncogene.

[18]  S. R. Datta,et al.  Cellular survival: a play in three Akts. , 1999, Genes & development.

[19]  J. Downward,et al.  Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells* , 1999, The Journal of Biological Chemistry.

[20]  S. Akira,et al.  Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. , 1999, Genes & development.

[21]  J. Romashkova,et al.  NF-κB is a target of AKT in anti-apoptotic PDGF signalling , 1999, Nature.

[22]  S. Tsai,et al.  Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B , 1999, Oncogene.

[23]  W. Liu,et al.  Heregulin regulation of Akt/protein kinase B in breast cancer cells. , 1999, Biochemical and biophysical research communications.

[24]  R. Glazer,et al.  Role of AKT1 in 17β-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells , 1999 .

[25]  S. Anderson,et al.  Epidermal Growth Factor Protects Epithelial Cells against Fas-induced Apoptosis , 1999, The Journal of Biological Chemistry.

[26]  N. Pavletich.  Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. , 1999, Journal of molecular biology.

[27]  M. Roussel,et al.  Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. , 1998, Genes & development.

[28]  N. Rosen,et al.  Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway* , 1998, The Journal of Biological Chemistry.

[29]  Frank McCormick,et al.  Akt activation by growth factors is a multiple-step process: the role of the PH domain , 1998, Oncogene.

[30]  B. van der Burg,et al.  Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase* , 1997, The Journal of Biological Chemistry.

[31]  L. Peso,et al.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.

[32]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[33]  P. Cohen,et al.  PDK1, one of the missing links in insulin signal transduction? 1 , 1997, FEBS letters.

[34]  P. Tsichlis,et al.  Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[35]  L. Hennighausen,et al.  Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[36]  P. Cohen,et al.  Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.

[37]  N. Hynes,et al.  Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities (*) , 1996, The Journal of Biological Chemistry.

[38]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[39]  R. Sharp,et al.  Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells. , 1995, The American journal of pathology.

[40]  R. Palmiter,et al.  Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. , 1995, Cancer research.

[41]  J. Cheng,et al.  Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas , 1995, International journal of cancer.

[42]  Emma Lees,et al.  Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice , 1994, Nature.

[43]  J. Haycock.  Polyvinylpyrrolidone as a blocking agent in immunochemical studies. , 1993, Analytical biochemistry.

[44]  E. Southern.  Detection of specific sequences among DNA fragments separated by gel electrophoresis. , 1975, Journal of molecular biology.

[45]  M. Andjelkovic,et al.  Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells. , 1998, European journal of biochemistry.