论文信息 - Modern control theory and optimal drug regimens, I: the plateau effect

Modern control theory and optimal drug regimens, I: the plateau effect

Abstract It is assumed that the pharmacokinetics of certain drugs (digitalis drugs, sulfa drugs, etc.) are described by a model of E. Kruger-Thiemer. An initial dose and regular maintenance doses are to be given so as to achieve body levels of the drug that show neither accumulation nor depletion (the plateau effect). The suggested dose regimens are displayed in the form of nomograms.

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