Effects of the combination of gentamicin and carbenicillin on the bactericidal activity of serum.

The bactericidal activity of serum from five patients treated successively with gentamicin, carbenicillin, and gentamicin plus carbenicillin, was tested against 14 randomly chosen strains of Pseudomonas aeruginosa. The bactericidal effect of sera obtained after the administration of gentamicin and carbenicillin together was significantly higher (P < .01) than that of sera obtained after the injection of either gentamicin or carbenicillin alone.

[1]  G. Jackson,et al.  Gentamicin plus carbenicillin. , 1971, Lancet.

[2]  D. Reeves,et al.  Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin. , 1971, Lancet.

[3]  J. Klastersky,et al.  Antimicrobial activity of the carbenicillin-gentamicin combination against gram-negative bacilli. , 1970, The American journal of the medical sciences.

[4]  T. Eickhoff.  In vitro effects of carbenicillin combined with gentamicin or polymyxin B against Pseudomonas aeruginosa. , 1969, Applied microbiology.

[5]  G. Bodey,et al.  Carbenicillin Therapy of Gram‐Negative Bacilli Infections , 1969, The American journal of the medical sciences.

[6]  P. Dans,et al.  Use of gentamicin in combinations with other antibiotics. , 1969, The Journal of infectious diseases.

[7]  A. Percival,et al.  Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea. , 1967, Lancet.

[8]  G. Jackson,et al.  TREATMENT OF PYELONEPHRITIS: BACTERIAL, DRUG AND HOST FACTORS IN SUCCESS OR FAILURE AMONG 252 PATIENTS. , 1965, The New England journal of medicine.

[9]  M. Finland,et al.  GENTAMICIN: ACTIVITY in Vitro AND OBSERVATIONS IN 26 PATIENTS , 1964, The American journal of the medical sciences.

[10]  R. L. Plackett,et al.  The Analysis of Variance , 1960 .

[11]  E. Steers,et al.  An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. , 1959, Antibiotics & chemotherapy.

[12]  T. Hunter.  The treatment of subacute bacterial endocarditis with antibiotics. , 1946, The American journal of medicine.

[13]  E. Jawetz.  The use of combinations of antimicrobial drugs. , 1968, Annual review of pharmacology.