Fibroblast Growth Factor-2 Signaling in Neurogenesis and Neurodegeneration

[1]  F. Calderon,et al.  Heparin crosslinked chitosan microspheres for the delivery of neural stem cells and growth factors for central nervous system repair. , 2013, Acta biomaterialia.

[2]  E. D. Kirby,et al.  Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2 , 2013, eLife.

[3]  M. Lynch,et al.  The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner , 2013, Neuroscience.

[4]  C. Grothe,et al.  Fibroblast growth factor 2 regulates adequate nigrostriatal pathway formation in mice , 2012, The Journal of comparative neurology.

[5]  M. Lynch,et al.  An NCAM Mimetic, FGL, Alters Hippocampal Cellular Morphometry in Young Adult (4 Month-Old) Rats , 2012, Neurochemical Research.

[6]  M. Stewart,et al.  Age-related changes in the hippocampus (loss of synaptophysin and glial–synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL , 2012, Brain, Behavior, and Immunity.

[7]  R. Klein,et al.  The advent of AAV9 expands applications for brain and spinal cord gene delivery , 2012, Expert opinion on biological therapy.

[8]  K. Nave,et al.  Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness , 2012, The Journal of Neuroscience.

[9]  Xin-guo Jiang,et al.  Enhancement of nose-to-brain delivery of basic fibroblast growth factor for improving rat memory impairments induced by co-injection of β-amyloid and ibotenic acid into the bilateral hippocampus. , 2012, International journal of pharmaceutics.

[10]  Eduardo D. Martín,et al.  Facilitation of AMPA Receptor Synaptic Delivery as a Molecular Mechanism for Cognitive Enhancement , 2012, PLoS biology.

[11]  E. Shohami,et al.  Combination of Vascular Endothelial and Fibroblast Growth Factor 2 for Induction of Neurogenesis and Angiogenesis after Traumatic Brain Injury , 2012, Journal of Molecular Neuroscience.

[12]  T. Kiyota,et al.  AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice , 2011, Gene Therapy.

[13]  M. Lynch,et al.  A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus , 2011, Experimental Neurology.

[14]  Huangui Xiong,et al.  FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders , 2011, Proceedings of the National Academy of Sciences.

[15]  F. de Castro,et al.  FGF-2 and Anosmin-1 Are Selectively Expressed in Different Types of Multiple Sclerosis Lesions , 2011, The Journal of Neuroscience.

[16]  K. Unsicker,et al.  Fibroblast growth factor‐2 deficiency causes defects in adult hippocampal neurogenesis, which are not rescued by exogenous fibroblast growth factor‐2 , 2011, Journal of neuroscience research.

[17]  K. Addicks,et al.  Neuroprotective role of fibroblast growth factor‐2 in experimental autoimmune encephalomyelitis , 2011, Immunology.

[18]  Y. Tabata,et al.  Combined transplantation of bone marrow stromal cell-derived neural progenitor cells with a collagen sponge and basic fibroblast growth factor releasing microspheres enhances recovery after cerebral ischemia in rats. , 2011, Tissue engineering. Part A.

[19]  C. Rampon,et al.  The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo. , 2011, Learning & memory.

[20]  J. V. van Deursen,et al.  CREB Binding Protein Is Required for Both Short-Term and Long-Term Memory Formation , 2010, The Journal of Neuroscience.

[21]  M. Oh,et al.  Genipin inhibits the inflammatory response of rat brain microglial cells. , 2010, International immunopharmacology.

[22]  L. Lue,et al.  Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease , 2010, Molecular Neurobiology.

[23]  M. Lynch,et al.  A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , 2010, Neurobiology of Aging.

[24]  M. Lynch,et al.  A synthetic NCAM‐derived mimetic peptide, FGL, exerts anti‐inflammatory properties via IGF‐1 and interferon‐γ modulation , 2009, Journal of neurochemistry.

[25]  R. Colello,et al.  Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury , 2009, Experimental Neurology.

[26]  K. Fuxe,et al.  Involvement of astroglial fibroblast growth factor-2 and microglia in the nigral 6-OHDA parkinsonism and a possible role of glucocorticoid hormone on the glial mediated local trophism and wound repair. , 2009, Journal of neural transmission. Supplementum.

[27]  A. Bikfalvi,et al.  Overexpression of high molecular weight FGF-2 forms inhibits glioma growth by acting on cell-cycle progression and protein translation. , 2008, Experimental cell research.

[28]  P. Calabresi,et al.  Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patients , 2008, Neuroscience Letters.

[29]  P. Richardson,et al.  Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair. , 2008, Restorative neurology and neuroscience.

[30]  W. Wilcox,et al.  The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up‐regulated in B cell chronic lymphoid leukemia , 2007, Journal of leukocyte biology.

[31]  A. Shetty,et al.  Enhanced production and dendritic growth of new dentate granule cells in the middle‐aged hippocampus following intracerebroventricular FGF‐2 infusions , 2007, The European journal of neuroscience.

[32]  M. Lynch,et al.  CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4 , 2007, The Journal of Neuroscience.

[33]  Y. Tabata,et al.  A novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study. , 2007, Circulation journal : official journal of the Japanese Circulation Society.

[34]  B. Pakkenberg,et al.  A neural cell adhesion molecule–derived peptide reduces neuropathological signs and cognitive impairment induced by Aβ25-35 , 2007, Neuroscience.

[35]  Esther Lipokatic-Takacs,et al.  Fibroblast Growth Factor (FGF)-2 and FGF Receptor 3 Are Required for the Development of the Substantia Nigra, and FGF-2 Plays a Crucial Role for the Rescue of Dopaminergic Neurons after 6-Hydroxydopamine Lesion , 2007, The Journal of Neuroscience.

[36]  M. Seiberling,et al.  Tolerability, Safety and Pharmacokinetics of the FGLL Peptide, a Novel Mimetic of Neural Cell Adhesion Molecule, Following Intranasal Administration in Healthy Volunteers , 2007, Clinical pharmacokinetics.

[37]  B. Pakkenberg,et al.  A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35. , 2007, Neuroscience.

[38]  R. Armstrong,et al.  Retroviral lineage analysis of fibroblast growth factor receptor signaling in FGF2 inhibition of oligodendrocyte progenitor differentiation , 2006, Glia.

[39]  W. Nickel,et al.  Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2 , 2006, Proceedings of the National Academy of Sciences.

[40]  W. Streit,et al.  Microglia in the Aging Brain , 2006, Journal of neuropathology and experimental neurology.

[41]  X. Fang,et al.  Control of CREB-binding Protein Signaling by Nuclear Fibroblast Growth Factor Receptor-1 , 2005, Journal of Biological Chemistry.

[42]  H. Neumann,et al.  Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2 , 2005, The Journal of experimental medicine.

[43]  Claus Christensen,et al.  An NCAM‐derived FGF‐receptor agonist, the FGL‐peptide, induces neurite outgrowth and neuronal survival in primary rat neurons , 2004, Journal of neurochemistry.

[44]  V. Berezin,et al.  Zippers Make Signals: NCAM-mediated Molecular Interactions and Signal Transduction , 2004, Neurochemical Research.

[45]  J. Partanen,et al.  Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse , 2022 .

[46]  M. Mayford,et al.  CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation , 2004, Neuron.

[47]  V. Berezin,et al.  A Synthetic Neural Cell Adhesion Molecule Mimetic Peptide Promotes Synaptogenesis, Enhances Presynaptic Function, and Facilitates Memory Consolidation , 2004, The Journal of Neuroscience.

[48]  J. Bernhagen,et al.  Unconventional Secretion of Fibroblast Growth Factor 2 Is Mediated by Direct Translocation across the Plasma Membrane of Mammalian Cells , 2004, Journal of Biological Chemistry.

[49]  Hiroki Toda,et al.  Inflammatory Blockade Restores Adult Hippocampal Neurogenesis , 2003, Science.

[50]  W. Manning,et al.  Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury , 2003, Molecular and Cellular Neuroscience.

[51]  K. Jin,et al.  Neurogenesis and aging: FGF‐2 and HB‐EGF restore neurogenesis in hippocampus and subventricular zone of aged mice , 2003, Aging cell.

[52]  Elisabeth Bock,et al.  Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. , 2003, Structure.

[53]  A. Prats,et al.  Generation of protein isoform diversity by alternative initiation of translation at non‐AUG codons , 2003, Biology of the cell.

[54]  X. Fang,et al.  cAMP‐induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor‐1 (FGFR1) , 2003, Journal of neurochemistry.

[55]  P. Claus,et al.  Differential Intranuclear Localization of Fibroblast Growth Factor-2 Isoforms and Specific Interaction with the Survival of Motoneuron Protein* , 2003, The Journal of Biological Chemistry.

[56]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[57]  A. Barclay,et al.  CD200 and membrane protein interactions in the control of myeloid cells. , 2002, Trends in immunology.

[58]  G. Comi,et al.  Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice , 2001, Gene Therapy.

[59]  M. Cobb,et al.  Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. , 2001, Endocrine reviews.

[60]  R. Armstrong,et al.  Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination† , 2000, Journal of neuroscience research.

[61]  A. Mackay-Sim,et al.  Growth factor regulation of neurogenesis in adult olfactory epithelium , 2000, Neuroscience.

[62]  V. Berezin,et al.  Neural Cell Adhesion Molecule-Stimulated Neurite Outgrowth Depends on Activation of Protein Kinase C and the Ras–Mitogen-Activated Protein Kinase Pathway , 2000, The Journal of Neuroscience.

[63]  I. Delrieu.  The high molecular weight isoforms of basic fibroblast growth factor (FGF‐2): an insight into an intracrine mechanism , 2000, FEBS letters.

[64]  A. Prats,et al.  A New 34-Kilodalton Isoform of Human Fibroblast Growth Factor 2 Is Cap Dependently Synthesized by Using a Non-AUG Start Codon and Behaves as a Survival Factor , 1999, Molecular and Cellular Biology.

[65]  R. Zeller,et al.  Impaired cerebral cortex development and blood pressure regulation in FGF‐2‐deficient mice , 1998, The EMBO journal.

[66]  P. Cattini,et al.  Over-expression of the 18 kD and 21/23 kD fibroblast growth factor-2 isoforms in PC12 cells and Schwann cells results in altered cell morphology and growth. , 1998, Brain research. Molecular brain research.

[67]  R. Florkiewicz,et al.  The Inhibition of Fibroblast Growth Factor-2 Export by Cardenolides Implies a Novel Function for the Catalytic Subunit of Na+,K+-ATPase* , 1998, The Journal of Biological Chemistry.

[68]  I. Black,et al.  In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor. , 1997, Journal of neurobiology.

[69]  S. Coons,et al.  Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells , 1997, Oncogene.

[70]  I. Black,et al.  Neurogenesis in neonatal rat brain is regulated by peripheral injection of basic fibroblast growth factor (bFGF) , 1996, The Journal of comparative neurology.

[71]  N. Itoh,et al.  Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor‐2 and ‐3 mRNAs , 1996, Journal of neuroscience research.

[72]  E. Parati,et al.  Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[73]  F. Gage,et al.  FGF-2-Responsive Neuronal Progenitors Reside in Proliferative and Quiescent Regions of the Adult Rodent Brain , 1995, Molecular and Cellular Neuroscience.

[74]  J. Furness,et al.  FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors. , 1994, Development.

[75]  K. Abe,et al.  Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons , 1994, Brain Research.

[76]  A. El-Husseini,et al.  Basic fibroblast growth factor (BFGF) and two of its receptors, FGFR1 and FGFR2: gene expression in the rat brain during postnatal development as determined by quantitative RT-PCR , 1994, Molecular and Cellular Endocrinology.

[77]  M. Tohyama,et al.  Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system. , 1993, Brain research. Molecular brain research.

[78]  M. Jaye,et al.  Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. , 1992, Biochimica et biophysica acta.

[79]  K. Abe,et al.  Epidermal growth factor and basic fibroblast growth factor promote the generation of long-term potentiation in the dentate gyrus of anaesthetized rats , 1991, Neuroscience Research.

[80]  D. Rifkin,et al.  Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells. , 1991, Cell regulation.

[81]  S. Finklestein,et al.  Temporal, differential and regional expression of mRNA for basic fibroblast growth factor in the developing and adult rat brain. , 1991, Brain research. Molecular brain research.

[82]  W. Seifert,et al.  Fibroblast Growth Factor Enhances Long‐term Potentiation in the Hippocampal Slice , 1990, The European journal of neuroscience.

[83]  A. Sommer,et al.  Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[84]  D. Rifkin,et al.  Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan , 1989, Journal of cellular physiology.

[85]  T. Maciag,et al.  The heparin-binding (fibroblast) growth factor family of proteins. , 1989, Annual review of biochemistry.

[86]  R. Bradshaw,et al.  Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. , 1986, Proceedings of the National Academy of Sciences of the United States of America.