An androgen receptor regulated gene score is associated with epithelial to mesenchymal transition features in triple negative breast cancers

[1]  C. Caldas,et al.  Androgen receptor function and targeted therapeutics across breast cancer subtypes , 2022, Breast Cancer Research.

[2]  M. Ahram,et al.  The Association of RGS2 and Slug in the Androgen-induced Acquisition of Mesenchymal Features of Breast MDA-MB-453 Cancer Cells , 2022, Endocrine research.

[3]  Ping Li,et al.  Androgen receptor regulates eIF5A2 expression and promotes prostate cancer metastasis via EMT , 2021, Cell death discovery.

[4]  M. Ahram,et al.  Androgen downregulates desmocollin‐2 in association with induction of mesenchymal transition of breast MDA‐MB‐453 cancer cells , 2021, Cytoskeleton.

[5]  A. Korlimarla,et al.  Pre-Menopausal Women With Breast Cancers Having High AR/ER Ratios in the Context of Higher Circulating Testosterone Tend to Have Poorer Outcomes , 2021, Frontiers in Endocrinology.

[6]  K. Gyftopoulos,et al.  Cell Plasticity and Prostate Cancer: The Role of Epithelial–Mesenchymal Transition in Tumor Progression, Invasion, Metastasis and Cancer Therapy Resistance , 2021, Cancers.

[7]  M. Ahram,et al.  Involvement of β-catenin in Androgen-induced Mesenchymal Transition of Breast MDA-MB-453 Cancer Cells , 2021, Endocrine research.

[8]  I. Ellis,et al.  The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer , 2021, Nature Medicine.

[9]  C. Gu,et al.  Steroid 5α-Reductase Type I Induces Cell Viability and Migration via Nuclear Factor-κB/Vascular Endothelial Growth Factor Signaling Pathway in Colorectal Cancer , 2020, Frontiers in Oncology.

[10]  A. Korlimarla,et al.  miR‐18a activates Wnt pathway in ER‐positive breast cancer and is associated with poor prognosis , 2020, Cancer medicine.

[11]  Raymond B. Runyan,et al.  Guidelines and definitions for research on epithelial–mesenchymal transition , 2020, Nature Reviews Molecular Cell Biology.

[12]  C. Decaestecker,et al.  A Novel Approach for Quantifying Cancer Cells Showing Hybrid Epithelial/Mesenchymal States in Large Series of Tissue Samples: Towards a New Prognostic Marker , 2020, Cancers.

[13]  Jeong Hwan Park,et al.  Influence of Androgen Receptor on the Prognosis of Breast Cancer , 2020, Journal of clinical medicine.

[14]  J. Boughey,et al.  Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties , 2019, Annals of Surgical Oncology.

[15]  R. Tamimi,et al.  Consideration of breast cancer subtype in targeting the androgen receptor. , 2019, Pharmacology & therapeutics.

[16]  I. Ellis,et al.  Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study , 2019, Cancers.

[17]  R. Tirumalae,et al.  Expression of androgen receptor in primary breast carcinoma and its relation with clinicopathologic features, estrogen, progesterone, and her-2 receptor status , 2019, Journal of cancer research and therapeutics.

[18]  R. Khairy,et al.  Immunohistochemical Expression of Androgen Receptors (AR) in Various Breast Cancer Subtypes , 2019, Open access Macedonian journal of medical sciences.

[19]  R. Weinberg,et al.  Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells , 2019, Proceedings of the National Academy of Sciences.

[20]  G. Castoria,et al.  Androgens Induce Invasiveness of Triple Negative Breast Cancer Cells Through AR/Src/PI3-K Complex Assembly , 2019, Scientific Reports.

[21]  O. Haugen,et al.  The prognostic value of androgen receptors in breast cancer subtypes , 2018, Breast Cancer Research and Treatment.

[22]  L. Tang,et al.  Clinical significance of androgen receptor expression in triple negative breast cancer-an immunohistochemistry study. , 2018, Oncology letters.

[23]  T. Voet,et al.  Identification of the tumour transition states occurring during EMT , 2018, Nature.

[24]  K. Rubinow.  An intracrine view of sex steroids, immunity, and metabolic regulation , 2018, Molecular metabolism.

[25]  S. Vowler,et al.  The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome , 2018, Clinical Cancer Research.

[26]  A. Daemen,et al.  HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors , 2018, Breast Cancer Research.

[27]  Peter Schmid,et al.  Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  J. Trepel,et al.  Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer , 2018, Hormones and Cancer.

[29]  Mohit Kumar Jolly,et al.  Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric. , 2017, Cancer research.

[30]  K. Storbeck,et al.  Intracrine androgen biosynthesis, metabolism and action revisited , 2017, Molecular and Cellular Endocrinology.

[31]  A. Korlimarla,et al.  Dissecting the Biological Heterogeneity within Hormone Receptor Positive HER2 Negative Breast Cancer by Gene Expression Markers Identifies Indolent Tumors within Late Stage Disease , 2017, Translational oncology.

[32]  P. Bendahl,et al.  Androgen receptor expression and breast cancer mortality in a population-based prospective cohort , 2017, Breast Cancer Research and Treatment.

[33]  N. Husain,et al.  Androgen Receptor Expression in an Indian Breast Cancer Cohort with Relation to Molecular Subtypes and Response to Neoadjuvant Chemotherapy - a Prospective Clinical Study , 2017, Breast Care.

[34]  Jun Lu,et al.  Androgen and AR contribute to breast cancer development and metastasis: an insight of mechanisms , 2017, Oncogene.

[35]  Martin H. Schaefer,et al.  HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks , 2016, Nucleic Acids Res..

[36]  I. Ellis,et al.  Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis , 2016, Breast Cancer Research and Treatment.

[37]  J. Remacle,et al.  β3 integrin promotes chemoresistance to epirubicin in MDA-MB-231 through repression of the pro-apoptotic protein, BAD. , 2016, Experimental cell research.

[38]  N. Elmashad,et al.  Androgen receptor expression as a prognostic and predictive marker in triple-negative breast cancer patients , 2016 .

[39]  T. Traina,et al.  Targeting the androgen receptor in triple-negative breast cancer. , 2016, Current problems in cancer.

[40]  J. Parker,et al.  Abstract P3-07-25: Improved clinical outcomes on enzalutamide observed in patients with PREDICT AR+ triple-negative breast cancer: prognosis or prediction? , 2016 .

[41]  E. Warner,et al.  Complete Response of Metastatic Androgen Receptor-Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  K. Hirakawa,et al.  Clinical verification of sensitivity to preoperative chemotherapy in cases of androgen receptor-expressing positive breast cancer , 2016, British Journal of Cancer.

[43]  D. Tang,et al.  Prostate Cancer Stem-like Cells Contribute to the Development of Castration-Resistant Prostate Cancer , 2015, Cancers.

[44]  Jaime Rodriguez-Canales,et al.  A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition , 2015, Clinical Cancer Research.

[45]  Daniel S. Himmelstein,et al.  Understanding multicellular function and disease with human tissue-specific networks , 2015, Nature Genetics.

[46]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[47]  T. Tan,et al.  Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients , 2014, EMBO molecular medicine.

[48]  Gordon B Mills,et al.  Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer , 2014, Clinical Cancer Research.

[49]  Debjani Roy,et al.  Construction and Analysis of the Protein-Protein Interaction Networks Based on Gene Expression Profiles of Parkinson's Disease , 2014, PloS one.

[50]  B. Overmoyer,et al.  Enobosarm: A targeted therapy for metastatic, androgen receptor positive, breast cancer. , 2014 .

[51]  Yibin Kang,et al.  Multilayer control of the EMT master regulators , 2014, Oncogene.

[52]  J. Remacle,et al.  Separate quality-control measures are necessary for estimation of RNA and methylated DNA from formalin-fixed, paraffin-embedded specimens by quantitative PCR. , 2014, The Journal of molecular diagnostics : JMD.

[53]  N. Dendukuri,et al.  A Majority of Low (1-10%) ER Positive Breast Cancers Behave Like Hormone Receptor Negative Tumors , 2014, Journal of Cancer.

[54]  Benjamin E. Gross,et al.  Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.

[55]  Stefan Glück,et al.  Molecular Profiling for Breast Cancer: A Comprehensive Review , 2013, Biomarkers in cancer.

[56]  J. Wong,et al.  Abstract P5-01-09: Identification of Molecular Apocrine Triple Negative Breast Cancer Using a Novel 2-Gene Assay and Comparison with Androgen Receptor Protein Expression and Gene Expression Profiling by DASL , 2012 .

[57]  G. Buchanan,et al.  Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cells. , 2012, Molecular endocrinology.

[58]  M. Gleave,et al.  Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer. , 2012, Molecular endocrinology.

[59]  Martin H. Schaefer,et al.  HIPPIE: Integrating Protein Interaction Networks with Experiment Based Quality Scores , 2012, PloS one.

[60]  P. Graves,et al.  Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance. , 2011, Archives of biochemistry and biophysics.

[61]  N. Kyprianou,et al.  Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis , 2011, Expert review of endocrinology & metabolism.

[62]  Lajos Pusztai,et al.  A clinically relevant gene signature in triple negative and basal-like breast cancer , 2010, Breast Cancer Research.

[63]  L. Ngo,et al.  Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[64]  N. Kyprianou,et al.  Role of androgens and the androgen receptor in epithelial‐mesenchymal transition and invasion of prostate cancer cells , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[65]  A. Osunkoya,et al.  Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells , 2009, Breast Cancer Research and Treatment.

[66]  Han-Jung Lee,et al.  Activated Androgen Receptor Downregulates E-Cadherin Gene Expression and Promotes Tumor Metastasis , 2008, Molecular and Cellular Biology.

[67]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[68]  Rafael A Irizarry,et al.  Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.

[69]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[70]  Bentong Yu,et al.  GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer. , 2017, American journal of translational research.

[71]  Y. Bae,et al.  Androgen Receptor Expression Predicts Decreased Survival in Early Stage Triple-Negative Breast Cancer , 2014, Annals of Surgical Oncology.

[72]  Yibo Wu,et al.  GOSemSim: an R package for measuring semantic similarity among GO terms and gene products , 2010, Bioinform..

[73]  David Cameron,et al.  Identification of molecular apocrine breast tumours by microarray analysis , 2005, Oncogene.