Concentration of macromolecules from aqueous solutions : a new swellex process

A new swellex process (extraction through swelling polymers) to concentrate macromolecules from aqueous solutions has been demonstrated. Dilute solutions of biological macromolecules such as proteins have been concentrated with good recoveries and high selectivity. The selectivity was controlled by the extent of crosslinking in the gels. Electrolyte solution when pulsed through the column, causes the collapse of the gel. The reversible volume phase transition has been exploited for the regeneration of the gels.