Neuronal activity in human anterior cingulate cortex modulates with internal cognitive state during multi-source interference task

The dorsal anterior cingulate cortex (dACC) is thought to be essential for normal adaptation of one's behavior to difficult decisions, errors, and reinforcement. Here we examine single neurons from the human dACC in the context of a statistical model, including a cognitive state that varies with changes in cognitive interference induced by a Stroop-like task. We then include this cognitive state in point process models of single unit activity and subject reaction time. These results suggest that consideration of a latent cognitive state can explain additional variance in neural and behavioral dynamics.

[1]  Uri T Eden,et al.  A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects. , 2005, Journal of neurophysiology.

[2]  Shaun R. Patel,et al.  Human Dorsal Anterior Cingulate Cortex Neurons Mediate Ongoing Behavioral Adaptation , 2012, Nature.

[3]  Benjamin Y Hayden,et al.  Dorsal Anterior Cingulate Cortex: A Bottom-Up View. , 2016, Annual review of neuroscience.

[4]  Sydney S. Cash,et al.  Frequency-dependent representation of reinforcement-related information in the human medial and lateral prefrontal cortex , 2015 .

[5]  J. González-Martínez,et al.  Lucky Rhythms in Orbitofrontal Cortex Bias Gambling Decisions in Humans , 2016, Scientific Reports.

[6]  E. Brown.  Course 14 - Theory of Point Processes for Neural Systems , 2005 .

[7]  John A. Nelder,et al.  Generalized linear models. 2nd ed. , 1993 .

[8]  Samuel Kotz,et al.  Continuous univariate distributions : distributions in statistics , 1970 .

[9]  Shy Shoham,et al.  Robust, automatic spike sorting using mixtures of multivariate t-distributions , 2003, Journal of Neuroscience Methods.

[10]  Emery N. Brown,et al.  Computational Neuroscience: A Comprehensive Approach , 2022 .

[11]  Donald L. Snyder,et al.  Random Point Processes in Time and Space , 1991 .

[12]  Kevin Kahn,et al.  Performing behavioral tasks in subjects with intracranial electrodes. , 2014, Journal of visualized experiments : JoVE.

[13]  David Vere-Jones,et al.  Point Processes , 2011, International Encyclopedia of Statistical Science.

[14]  G. Bush,et al.  The Multi-Source Interference Task: an fMRI task that reliably activates the cingulo-frontal-parietal cognitive/attention network , 2006, Nature Protocols.

[15]  B. Hayden,et al.  Dorsal anterior cingulate: a Rorschach test for cognitive neuroscience , 2016, Nature Neuroscience.

[16]  W. R. Buckland,et al.  Distributions in Statistics: Continuous Multivariate Distributions , 1974 .