Wirelessly powered and controlled, implantable, multi-channel, multi-wavelength optogenetic stimulator

In recent years, major developments in RF based power transmission systems have made a great impact in the progress of wirelessly powered implantable biomedical devices. In this paper, we present a multichannel and multi-wavelength optogenetic stimulator, suitable for chronic and acute implantation in freely moving rodents. Optogenetic stimulators provide a pathway for complex spatiotemporal control of photosensitized neurons in the brain. The design consists of an 8×8 micro light emitting diode array of equally spaced amber and blue LED pairs at alternate positions. The closely packed illumination structure facilitates light delivery at a high spatial (0.5mm) and temporal (0.1 ms) resolution. Low Frequency RFID (Radio Frequency Identification) technique was used for both power delivery and communication with the onboard low power microcontroller via custom built Reader circuitry.

[1]  Yasushi Miyashita,et al.  A glass-coated tungsten microelectrode enclosing optical fibers for optogenetic exploration in primate deep brain structures , 2012, Journal of Neuroscience Methods.

[2]  Feng Zhang,et al.  An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology , 2007, Journal of neural engineering.

[3]  K. Nikolic,et al.  Photostimulator for optogenetic retinal prosthesis , 2009, 2009 4th International IEEE/EMBS Conference on Neural Engineering.

[4]  E. Bamberg,et al.  Channelrhodopsin-2, a directly light-gated cation-selective membrane channel , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Patrick Degenaar,et al.  Multi-site optical excitation using ChR2 and micro-LED array , 2010, Journal of neural engineering.

[6]  E. Boyden,et al.  Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution , 2007, PloS one.

[7]  K. Deisseroth,et al.  Millisecond-timescale, genetically targeted optical control of neural activity , 2005, Nature Neuroscience.

[8]  Patrick Degenaar,et al.  Micro-LED arrays: a tool for two-dimensional neuron stimulation , 2008 .

[9]  Douglas S Kim,et al.  Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration , 2008, Nature Neuroscience.

[10]  Hongxing Jiang,et al.  Size dependence of III-nitride microdisk light-emitting diode characteristics , 2001 .