Materials and applications of bioresorbable electronics

Bioresorbable electronics is a new type of electronics technology that can potentially lead to biodegradable and dissolvable electronic devices to replace current built-to-last circuits predominantly used in implantable devices and consumer electronics. Such devices dissolve in an aqueous environment in time periods from seconds to months, and generate biological safe products. This paper reviews materials, fabrication techniques, and applications of bioresorbable electronics, and aims to inspire more revolutionary bioresorbable systems that can generate broader social and economic impact. Existing challenges and potential solutions in developing bioresorbable electronics have also been presented to arouse more joint research efforts in this field to build systematic technology framework.

[1]  N. Kirkland,et al.  Magnesium biomaterials: Past, present and future , 2012 .

[2]  R. Gurny,et al.  Long term performance of polycaprolactone vascular grafts in a rat abdominal aorta replacement model. , 2012, Biomaterials.

[3]  M. Allen,et al.  A Microfabricated Wireless RF Pressure Sensor Made Completely of Biodegradable Materials , 2012, Journal of Microelectromechanical Systems.

[4]  Justin A. Blanco,et al.  Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. , 2010, Nature materials.

[5]  Hemanth Jagannathan,et al.  Engineering High Dielectric Constant Materials for Band-Edge CMOS Applications , 2008 .

[6]  S. Bauer,et al.  Biocompatible and Biodegradable Materials for Organic Field‐Effect Transistors , 2010 .

[7]  Xian Huang,et al.  Materials for Bioresorbable Radio Frequency Electronics , 2013, Advanced materials.

[8]  John A Rogers,et al.  Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants , 2015, NPG Asia materials.

[9]  M. Ferruzzi,et al.  Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives , 2007 .

[10]  S. Bauer,et al.  Environmentally sustainable organic field effect transistors , 2010 .

[11]  C. Cui,et al.  Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications , 2016 .

[12]  Qi Wang,et al.  Feeding Single-Walled Carbon Nanotubes or Graphene to Silkworms for Reinforced Silk Fibers. , 2016, Nano letters.

[13]  Keith D K Luk,et al.  A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. , 2010, Biomaterials.

[14]  Y. Sohn,et al.  Development of FET-type albumin sensor for diagnosing nephritis. , 2008, Biosensors & bioelectronics.

[15]  Yin Gui-bo,et al.  Study of the electrospun PLA/silk fibroin-gelatin composite nanofibrous scaffold for tissue engineering. , 2009, Journal of biomedical materials research. Part A.

[16]  C. Ahn,et al.  Epitaxial MgO as an alternative gate dielectric for SiC transistor applications , 2008 .

[17]  K. Refson,et al.  The kinetics and mechanism of MgO dissolution , 1999 .

[18]  Jeremy Goldman,et al.  Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents , 2013, Advanced materials.

[19]  Heng Pan,et al.  Mechanically Milled Irregular Zinc Nanoparticles for Printable Bioresorbable Electronics. , 2017, Small.

[20]  M. Berggren,et al.  Electrocardiographic Recording with Conformable Organic Electrochemical Transistor Fabricated on Resorbable Bioscaffold , 2014, Advanced materials.

[21]  Zhenan Bao,et al.  Air‐Stable n‐Channel Organic Semiconductors Based on Perylene Diimide Derivatives without Strong Electron Withdrawing Groups , 2007 .

[22]  Xuesi Chen,et al.  Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds. , 2006, Journal of biomedical materials research. Part A.

[23]  Kyung Jin Seo,et al.  Bioresorbable Silicon Electronics for Transient Spatio-temporal Mapping of Electrical Activity from the Cerebral Cortex , 2016, Nature materials.

[24]  D. Williams,et al.  Surface properties and biocompatibility of solvent-cast poly[-caprolactone] films. , 2004, Biomaterials.

[25]  A. Fedoročková,et al.  Effects of pH and acid anions on the dissolution kinetics of MgO , 2008 .

[26]  Huanyu Cheng,et al.  Biodegradable elastomers and silicon nanomembranes/nanoribbons for stretchable, transient electronics, and biosensors. , 2015, Nano letters.

[27]  Brajesh Dubey,et al.  Impact of electronic waste disposal on lead concentrations in landfill leachate. , 2008, Environmental science & technology.

[28]  Jae-Woong Jeong,et al.  Materials and Fabrication Processes for Transient and Bioresorbable High‐Performance Electronics , 2013 .

[29]  Eileen Harkin-Jones,et al.  A study on the rate of degradation of the bioabsorbable polymer polyglycolic acid (PGA) , 2006 .

[30]  Biologically inspired graphene-chlorophyll phototransistors with high gain , 2013, 1306.3015.

[31]  J. Riu,et al.  Carbon nanotube field effect transistors for the fast and selective detection of human immunoglobulin G. , 2008, The Analyst.

[32]  M. Skrifvars,et al.  Natural fibres as reinforcement in polylactic acid (PLA) composites , 2003 .

[33]  Michael C. McAlpine,et al.  Graphene-based wireless bacteria detection on tooth enamel , 2012, Nature Communications.

[34]  Heng Pan,et al.  Low‐Cost Manufacturing of Bioresorbable Conductors by Evaporation–Condensation‐Mediated Laser Printing and Sintering of Zn Nanoparticles , 2017, Advanced materials.

[35]  Zhenan Bao,et al.  Fully biodegradable pressure sensor, viscoelastic behavior of PGS dielectric elastomer upon degradation , 2015, 2015 IEEE SENSORS.

[36]  Jeremy Goldman,et al.  A simplified in vivo approach for evaluating the bioabsorbable behavior of candidate stent materials. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[37]  Xian Huang,et al.  Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries , 2014, Advanced materials.

[38]  Rolf Gloor,et al.  Brominated flame retardants in waste electrical and electronic equipment: substance flows in a recycling plant. , 2005, Environmental science & technology.

[39]  D. Kaplan,et al.  Integration of silk protein in organic and light-emitting transistors. , 2011, Organic electronics.

[40]  M. Prabhakaran,et al.  Drug-loaded emulsion electrospun nanofibers: characterization, drug release and in vitro biocompatibility , 2015 .

[41]  Vamsi K Yadavalli,et al.  Conducting polymer-silk biocomposites for flexible and biodegradable electrochemical sensors. , 2016, Biosensors & bioelectronics.

[42]  Hirenkumar K. Makadia,et al.  Poly Lactic-co-Glycolic Acid ( PLGA ) as Biodegradable Controlled Drug Delivery Carrier , 2011 .

[43]  Young Jo Kim,et al.  Self-deployable current sources fabricated from edible materials. , 2013, Journal of materials chemistry. B.

[44]  Peter H Lin,et al.  Current advances in research and clinical applications of PLGA-based nanotechnology , 2009, Expert review of molecular diagnostics.

[45]  J. Rogers,et al.  Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement , 2014, Proceedings of the National Academy of Sciences.

[46]  Huanyu Cheng,et al.  A Physically Transient Form of Silicon Electronics , 2012, Science.

[47]  Yonggang Huang,et al.  Dissolution chemistry and biocompatibility of single-crystalline silicon nanomembranes and associated materials for transient electronics. , 2014, ACS nano.

[48]  Jun-Yong Bak,et al.  Oxide Thin-Film Transistors Fabricated Using Biodegradable Gate Dielectric Layer of Chicken Albumen , 2013 .

[49]  P. Lyu,et al.  Pentacene organic thin-film transistors with solution-based gelatin dielectric , 2013 .

[50]  Huanyu Cheng,et al.  Dissolution chemistry and biocompatibility of silicon- and germanium-based semiconductors for transient electronics. , 2015, ACS applied materials & interfaces.

[51]  Bonsang Gu,et al.  A dielectric-modulated field-effect transistor for biosensing. , 2007, Nature nanotechnology.

[52]  Tsu-Jae King,et al.  Silicon-nitride as a tunnel dielectric for improved SONOS-type flash memory , 2003, IEEE Electron Device Letters.

[53]  Yonggang Huang,et al.  Dissolvable Metals for Transient Electronics , 2014 .

[54]  Susan Mühl,et al.  Bio-Organic Electronics—Overview and Prospects for the Future , 2014 .

[55]  Yufeng Zheng,et al.  In vitro investigation of ultra-pure Zn and its mini-tube as potential bioabsorbable stent material , 2015 .

[56]  Gordon G Wallace,et al.  Biocompatible ionic liquid-biopolymer electrolyte-enabled thin and compact magnesium-air batteries. , 2014, ACS applied materials & interfaces.

[57]  John A Rogers,et al.  Materials for Programmed, Functional Transformation in Transient Electronic Systems , 2015, Advanced materials.

[58]  Mihai Irimia-Vladu,et al.  Indigo ‐ A Natural Pigment for High Performance Ambipolar Organic Field Effect Transistors and Circuits , 2012, Advanced materials.

[59]  X. Zhong,et al.  Novel anti-corrosion silicon dioxide coating prepared by sol–gel method for AZ91D magnesium alloy , 2008 .

[60]  Sumin Yun,et al.  Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases. , 2015, ACS nano.

[61]  Arokia Nathan,et al.  Organic thin-film transistor integration using silicon nitride gate dielectric , 2007 .

[62]  R. Langer,et al.  A tough biodegradable elastomer , 2002, Nature Biotechnology.

[63]  Sumona Sarkar,et al.  Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications. , 2006, Biomaterials.

[64]  R. Carter,et al.  Ultrafast triggered transient energy storage by atomic layer deposition into porous silicon for integrated transient electronics. , 2016, Nanoscale.

[65]  Ron Waksman,et al.  Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries. , 2008, Cardiovascular revascularization medicine : including molecular interventions.

[66]  Guillermo Antonio Ameer,et al.  Novel Citric Acid‐Based Biodegradable Elastomers for Tissue Engineering , 2004 .

[67]  Huanyu Cheng,et al.  Bioresorbable silicon electronic sensors for the brain , 2016, Nature.

[68]  Balakrishnan Ramesh Babu,et al.  Electrical and electronic waste: a global environmental problem. , 2007, Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA.

[69]  Huanyu Cheng,et al.  Dissolution Behaviors and Applications of Silicon Oxides and Nitrides in Transient Electronics , 2014 .

[70]  Ping Yao,et al.  Simultaneous nanoparticle formation and encapsulation driven by hydrophobic interaction of casein-graft-dextran and beta-carotene. , 2007, Journal of colloid and interface science.

[71]  Yufeng Zheng,et al.  Surface characteristics and corrosion behaviour of WE43 magnesium alloy coated by SiC film , 2012 .

[72]  Mihai Irimia-Vladu,et al.  Exotic materials for bio-organic electronics , 2011 .

[73]  Seeram Ramakrishna,et al.  Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[74]  K. Finnie,et al.  Biodegradability of sol–gel silica microparticles for drug delivery , 2009 .

[75]  S. Hackbarth,et al.  Investigation of Polylactic Acid (PLA) Nanoparticles as Drug Delivery Systems for Local Dermatotherapy , 2009, Pharmaceutical Research.

[76]  Myung-Seob Khil,et al.  Characterization of nano-structured poly(ε-caprolactone) nonwoven mats via electrospinning , 2003 .

[77]  Ke Yang,et al.  Biodegradable Materials for Bone Repairs: A Review , 2013 .

[78]  J. Birchall,et al.  The chemistry of aluminum and silicon in relation to Alzheimer's disease. , 1988, Clinical chemistry.

[79]  B. Rosenberg.  The Effect of Oxygen Adsorption on Photo‐ and Semiconduction of β‐Carotene , 1961 .

[80]  Maurizio Prato,et al.  Making carbon nanotubes biocompatible and biodegradable. , 2011, Chemical communications.

[81]  Shizhe Song,et al.  A Possible Biodegradable Magnesium Implant Material , 2007 .

[82]  Xian Huang,et al.  High‐Performance Biodegradable/Transient Electronics on Biodegradable Polymers , 2014, Advanced materials.

[83]  Paul Chen,et al.  Polylactic acid (PLA) synthesis and modifications: a review , 2009 .

[84]  M. Saunders,et al.  Magnesium oxide as a candidate high-κ gate dielectric , 2006 .