Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma

Background: As different tissue types have distinct capabilities to accumulate protoporphyrin IX, fluorescence diagnosis with aminolevulinic acid‐induced porphyrins (FDAP) could be used to discriminate between different types of tissue. Previous results demonstrated higher fluorescence ratios in squamous cell carcinoma (SCC) compared with actinic keratoses (AKs).

[1]  P. V. D. van de Kerkhof,et al.  Aneuploidy and proliferation in keratinocytic intraepidermal neoplasias , 2007, Experimental dermatology.

[2]  Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells , 2009, The British journal of dermatology.

[3]  Even Angell-Petersen,et al.  Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate. , 2006, The Journal of investigative dermatology.

[4]  P Lehmann,et al.  Preferential Relative Porphyrin Enrichment in Solar Keratoses upon Topical Application of ^‐Aminolevulinic Acid Methylester , 1998, Photochemistry and photobiology.

[5]  S. Gibson,et al.  A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization? , 1998, British Journal of Cancer.

[6]  P. V. D. van de Kerkhof,et al.  Heterogeneity of fluorescence in psoriasis after application of 5‐aminolaevulinic acid: an immunohistochemical study , 2006, The British journal of dermatology.

[7]  P. V. D. van de Kerkhof,et al.  Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid. , 2005, The Journal of investigative dermatology.

[8]  H. S. de Bruijn,et al.  Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate. , 2008, Journal of photochemistry and photobiology. B, Biology.

[9]  J E Hewett,et al.  Malignant potential of actinic keratoses and the controversy over treatment. A patient-oriented perspective. , 1991, Archives of dermatology.

[10]  P. V. D. van de Kerkhof,et al.  Fluorescence diagnosis in keratinocytic intraepidermal neoplasias. , 2007, Journal of the American Academy of Dermatology.

[11]  G. Rennie,et al.  MALIGNANT TRANSFORMATION OF SOLAR KERATOSES TO SQUAMOUS CELL CARCINOMA , 1988, The Lancet.

[12]  R. Marks,et al.  Spontaneous remission of solar keratoses: the case for conservative management , 1986, The British journal of dermatology.

[13]  P. V. D. van de Kerkhof,et al.  The effects of keratolytic pretreatment prior to fluorescence diagnosis and photodynamic therapy with aminolevulinic acid-induced porphyrins in psoriasis , 2010, The Journal of dermatological treatment.

[14]  R. Glogau The risk of progression to invasive disease. , 2000, Journal of the American Academy of Dermatology.

[15]  F. J. Ensell,et al.  ATMOSPHERIC OZONE AND FEMORAL FRACTURES , 1975, The Lancet.

[16]  Stefan Seeger,et al.  Metabolic Characterization of Tumor Cell–specific Protoporphyrin IX Accumulation After Exposure to 5‐Aminolevulinic Acid in Human Colonic Cells ¶ , 2002, Photochemistry and photobiology.

[17]  N. Conrad,et al.  Incipient intraepidermal cutaneous squamous cell carcinoma: a proposal for reclassifying and grading solar (actinic) keratoses. , 1999, Seminars in cutaneous medicine and surgery.

[18]  [Photodiagnostic tests. 3: Fluorescence diagnosis with delta-aminolevulinic acid-induced porphyrins (FDAP) in dermatology]. , 2000, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[19]  B A Lober,et al.  Actinic keratosis is squamous cell carcinoma. , 2000, Journal of the American Academy of Dermatology.

[20]  J Moan,et al.  On the pharmacokinetics of topically applied 5‐aminolevulinic acid and two of its esters , 2001, International journal of cancer.