Luteotropic role of the decidual tissue in the rat: dependency on intraluteal estradiol.

The decidual tissue (DT) of pregnant and pseudopregnant rats maintains progesterone secretion in the absence of PRL. However, the luteotropic activity of the decidua disappears in the absence of the pituitary or LH. Since the role of LH in the pregnant rat is mediated by estradiol, it was of interest to determine whether the luteotropic role of the DT is dependent upon intraluteal estradiol. Pseudopregnant rats, either hysterectomized or bearing DT, were hypophysectomized on day 9. Within 24 h, a precipitous reduction in serum progesterone was observed in the two groups. The intraluteal concentration of estradiol on day 12 also dropped after hypophysectomy from 4 ± 1 and 2.8 ± 0.5 pg/mg in DT-bearing and hysterectomized animals to 0.4 ± 0.3 and0.2 ± 0.1 pg/mg, respectively. Three days after hypophysectomy, the average weight of the decidualized uteri was 1.1 ± 0.3 g compared to 3.9 ± 0.3 g in intact controls. Insertion of a 1-cm testosterone (T1) capsule in DTbearing rats 24 h before hypophysectomy increa...

[1]  G. Gibori,et al.  Sites of androgen and estradiol production in the second half of pregnancy in the rat. , 1981, Biology of reproduction.

[2]  N. Poyser.  Prostaglandins in reproduction. , 1981 .

[3]  G. Gibori,et al.  Luteotropic action of decidual tissue in the pregnant rat. , 1980, Biology of reproduction.

[4]  P. Terranova.  Relationships among progesterone, androgen, and estradiol in corpora lutea and nonluteal ovarian compartments of pseudopregnant rats: effects of decidual tissue. , 1980, Endocrinology.

[5]  C. Weems.  Prostaglandins F in uterine and ovarian compartments and in plasma from the uterine vein, ovarian artery and vein, and abdominal aorta of pseudopregnant rats with and without deciduomata. , 1979, Prostaglandins.

[6]  J. Richards,et al.  A role for intraluteal estrogen in the mediation of luteinizing hormone action on the rat corpus luteum during pregnancy. , 1978, Endocrinology.

[7]  G. Gibori,et al.  Role of intraluteal estrogen in the regulation of the rat corpus luteum during pregnancy. , 1978, Endocrinology.

[8]  J. Richards,et al.  Dissociation of two distinct luteotropic effects of prolactin: regulation of luteinizing hormone-receptor content and progesterone secretion during pregnancy. , 1978, Endocrinology.

[9]  W. D. de Greef,et al.  Serum concentrations of progesterone, luteinizing hormone, follicle stimulating hormone and prolactin in pseudopregnant rats: effect of decidualization. , 1977, Endocrinology.

[10]  G. Gibori,et al.  The role of estrogen in the regulation of luteal progesterone secretion in the rat after day 12 of pregnancy. , 1977, Endocrinology.

[11]  V. Castracane,et al.  Luteotrophic action of decidual tissue in the rat: comparison of jugular and uterine vein progesterone levels, and the effect of ligation of the utero-ovarian conncections. , 1976, Biology of reproduction.

[12]  P. Keyes,et al.  Synthesis of 17beta-estradiol by isolated ovarian tissues of the pregnant rat: aromatization in the corpus luteum. , 1976, Endocrinology.

[13]  G. Gibori,et al.  The luteotrophic action of decidual tissue: the stimulating effect of decidualization on the serum progesterone level of pseudopregnant rats. , 1975, Endocrinology.

[14]  F. Karsch,et al.  Role of estrogen as initiator of daily LH surges in the ovariectomized rat. , 1975, Endocrinology.

[15]  G. Gibori,et al.  Luteotrophic action of decidual tissue in the rat. , 1974, Endocrinology.

[16]  G. Pepe,et al.  Factors affecting the dependency of LH in the regulation of corpus luteum progesterone secretion in the rat. , 1974, Endocrinology.

[17]  I. Rothchild,et al.  Temporal aspects of the regulation of corpus luteum function by luteinizing hormone, prolactin and placental luteotrophin during the first half of pregnancy in the rat. , 1974, Endocrinology.

[18]  S. Korenman,et al.  Estradiol radioimmunoassay without chromatography: procedure, validation and normal values. , 1974, The Journal of clinical endocrinology and metabolism.

[19]  G. Gibori,et al.  Conversion of testosterone to estrogen by isolated corpora lutea of pregnancy in the rat. , 1973, Biology of reproduction.

[20]  L. Anderson,et al.  Progesterone and Pregn-4-en-20α-ol-3-one in Ovarian Venous Blood During Various Reproductive States in the Rat1 , 1968 .

[21]  L. Anderson,et al.  UTERUS AND LIFE SPAN OF RAT CORPORA LUTEA. , 1964, Endocrinology.

[22]  F. Hisaw,et al.  Sequence of histological changes in the uterus and vagina of the rat during prolongation of pseudopregnancy associated with the presence of deciduomata. , 1953, The American journal of anatomy.