On Intelligence in Cells: The Case for Whole Cell Biology

Abstract Biology needs revolution. All my adult life, I have been lost with admiration for the achievements in molecular biology and genetics, and I have come to know many of the main proponents. Yet there is an alternative aspect: in studying the minutiae, we have lost sight of the whole cell as organism. Living cells within the body are modelled in this paper as coordinated but essentially autonomous entities. We shall see how independent cells in nature have remarkable abilities to make decisions and take constructive action, which correlate with the definitions of intelligence. We are taught that the brain controls everything that goes on in the body, yet in this paper, we discover that most of the body's cells are invisible to the brain and are indifferent to its regulation. We encounter a novel model of the brain in which the neuron is viewed as an ingenious entity that 'thinks' within itself. The brain is not a 'super computer' but an entire community of them. We shall set the reductionism of molecular biology and the elementary mechanisms of genetics into a more realistic perspective and will recognize that the cell as organism matters above all. In future, whole cell biology should become the focus of the biosciences and the intelligent cell lies at its heart.

[1]  Robert Rosen,et al.  Essays on Life Itself , 1999 .

[2]  Christian de Duve,et al.  A Guided Tour of the Living Cell , 1984 .

[3]  Dorian Aur,et al.  Neuronal spatial learning , 2007, Neural Processing Letters.

[4]  B. Ford.  Microscopical Substantiation of Intelligence in Living Cells , 2008 .

[5]  R. Silverstein.  Max Perutz and the Secret of Life , 2007 .

[6]  Hilary Gonzalez.  A Guided Tour of the Living Cell , 1985, The Yale Journal of Biology and Medicine.

[7]  J. Pickova.  The Measurement and Appraisal of Adult Intelligence , 1959 .

[8]  M. Morange.  The death of molecular biology? , 2008, History and philosophy of the life sciences.

[9]  A Change of Heart , 1997 .

[10]  Stazione zoologica di Napoli.  History and philosophy of the life sciences , 1979 .

[11]  Laura Otis.  Networking: Communicating with Bodies and Machines in the Nineteenth Century , 2001 .

[12]  Toshiyuki Nakagaki,et al.  Indecisive behavior of amoeba crossing an environmental barrier , 2007 .

[13]  H. Muller,et al.  Science and criticism , 1943 .

[14]  H. Gardner,et al.  Frames of Mind: The Theory of Multiple Intelligences , 1983 .

[15]  B. Ford.  Did Physics Matter to the Pioneers of Microscopy , 2009 .

[16]  R. Hooke.  Micrographia: Or Some Physiological Descriptions of Minute Bodies Made by Magnifying Glasses With Observations and Inquiries Thereupon , 2003 .

[17]  H. Whitaker,et al.  Brain, mind, and medicine : essays in eighteenth-century neuroscience , 2007 .

[18]  Lewis Wolpert.  How We Live and Why We Die: The Secret Lives of Cells , 2009 .

[19]  L. Fritz,et al.  A SIGNAL GLYCOPROTEIN WITH α‐d‐MANNOSYL RESIDUES IS INVOLVED IN THE WOUND‐HEALING RESPONSE OF ANTITHAMNION SPARSUM (CERAMIALES, RHODOPHYTA) 1 , 1993 .

[20]  P. Ball.  Cellular memory hints at the origins of intelligence , 2008, Nature.

[21]  Nels. Quevli.  Cell intelligence; the cause of growth, heredity and instinctive actions, illustrating that the cell is a conscious, intelligent being, and, by reason thereof, plans and builds all plants and animals in the same manner By Nels Quevli ... , 1916 .

[22]  S. Waaland.  Evidence for a species-specific cell fusion hormone in red algae , 2005, Protoplasma.

[23]  K. Thompson.  Cognitive and Analytical Psychology Howard Gardner .Frames of Mind: The Theory of Multiple Intelligences. New York, Basic Books, 1983. , 1985 .

[24]  Jeanne Mettner,et al.  A change of heart. , 2008, Minnesota medicine.

[25]  Linda G. Shapiro,et al.  A new neuron spike sorting method using maximal overlap discrete wavelet transform and rotated principal component analysis , 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).

[26]  B. Ford.  Enlightening Neuroscience: Microscopes and Microscopy in the Eighteenth Century , 2007 .

[27]  R. Cleland,et al.  Cell repair through cell fusion in the red algaGriffithsia pacifica , 2005, Protoplasma.

[28]  Olufunmilayo I Oloparde.  Genetics in clinical cancer care: a promise unfulfilled among minority populations. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.