Prevention of postoperative peritoneal adhesions: efficacy of povidone.

The appearance and severity of peritoneal adhesions after simple laparotomy and after adhesiolysis were studied in a rabbit model. Adhesions were induced by direct abrasion with latex glove and dry gauze; control rabbits had abrasion only. Study groups had abrasion and treatment with 10% or 25% povidone. Results showed a significant reduction in the number of adhesions and in the severity of adhesions after treatment with povidone. This study supports the further investigation of the efficacy of povidone in preventing postoperative peritoneal adhesions.

[1]  R. Filler,et al.  An assessment of the surgical treatment of adhesive small bowel obstruction in infants and children. , 1981, Journal of pediatric surgery.

[2]  M. Habal,et al.  Peritoneal adhesions: prevention with the use of hydrophilic polymer coatings. , 1980, Archives of surgery.

[3]  I. Cohn,et al.  Intraperitoneal povidone-iodine in experimental canine and murine peritonitis. , 1979, American journal of surgery.

[4]  O. W. Richards,et al.  The merck Index , 1978 .

[5]  E. V. van Hall,et al.  Prevention of peritoneal adhesions by the combined use of spongostan and 32% dextran 70: an experimental study in pigs. , 1978, Fertility and sterility.

[6]  L. Nyhus,et al.  Critical Operative Management of Small Bowel Obstruction , 1978, Annals of surgery.

[7]  H. Kaufman,et al.  Corneal endothelium damage with intraocular lenses: contact adhesion between surgical materials and tissue , 1977, Science.

[8]  Gilmore Oj.  A reappraisal of the use of antiseptics in surgical practice. , 1977 .

[9]  H. Kaufman,et al.  Prevention of endothelial damage from intraocular lens insertion. , 1977, Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology.

[10]  R. Neuwirth,et al.  Effect of thirty-two per cent dextran 70 on peritoneal adhesion formation. , 1975, American journal of obstetrics and gynecology.

[11]  M. Dixon,et al.  Multiple peritoneal adhesions related to starch and gauze fragments. , 1974, Journal of pediatric surgery.

[12]  H. Ellis.  The cause and prevention of postoperative intraperitoneal adhesions. , 1971, Surgery, gynecology & obstetrics.

[13]  T. Nagai,et al.  Dissolution Kinetics of Polyvinylpyrrolidone of Various Molecular Weights , 1970 .

[14]  Mattha Ag,et al.  Rheological studies on dispersions of polyvinylprrolidone. I. General flow characteristics. , 1970 .

[15]  J. Williamson,et al.  The Pathogenesis of Peritoneal Adhesions: An Ultrastructural Study , 1968, Annals of surgery.

[16]  F. Belzer.  The role of venous obstruction in the formation of intra‐abdominal adhesions: An experimental study , 1967, The British journal of surgery.

[17]  R. Baird,et al.  Surgical sponges: a cause of granuloma and adhesion formation. , 1967 .

[18]  H. Fadhli,et al.  Peritoneal adhesions; prevention with povidone and dextran 75. , 1965, Archives of surgery.

[19]  K. Kalambaheti,et al.  PREVENTION OF ADHESIONS WITH POLYVINYLPYRROLIDONE. PRELIMINARY REPORT. , 1964, Archives of surgery.

[20]  T. Hugh,et al.  Postoperative abdominal adhesions. An experimental study of the value of polyvinylpyrrolidone in prophylaxis , 1964, The British journal of surgery.

[21]  Adams Je.  Peritoneal adhesions: an experimental study. , 1913 .