Influence of the Retinal Blood Vessel Topography on the Variability of the Retinal Nerve Fiber Bundle Trajectories in the Human Retina.

PURPOSE To determine the relationship between the retinal blood vessel topography and the retinal nerve fiber bundle (RNFB) trajectories in the human retina. METHODS A previously collected dataset comprising 28 fundus photographs with traced RNFB trajectories was used. For all traced trajectories, the departure from our previously published RNFB trajectory model was calculated. Subsequently, we calculated, per subject, a "mean departure" for the superior-temporal and inferior-temporal region. We measured angles between a line connecting the optic nerve head (ONH) center and the fovea and lines connecting the ONH center and the crossings of the superior and inferior temporal arteries (arterial angles) and veins (venous angles) with circles around the ONH; circle radii were 25%, 50%, and 100% of the ONH center-to-fovea distance. We also defined two angles based on the location of the first arteriovenous crossing. Multiple linear regression analysis was performed with mean departure as dependent variable and refraction, ONH inclination, and vessel angles as independent variables. RESULTS In the superior-temporal region, refraction (P = 0.017), ONH inclination (P = 0.021), and the arterial angle corresponding to the middle circle (P < 0.001) were significant determinants of mean departure. Explained variance was 0.54. In the inferior-temporal region, the arterial angle corresponding to the largest circle (P = 0.002) was significant. Explained variance was 0.32. CONCLUSIONS The retinal blood vessel topography explains a significant part of the RNFB trajectory variability but only if (1) the vessel topography is assessed at an appropriate distance from the ONH and (2) the superior and inferior hemifield are addressed independently.

[1]  R. Asaoka,et al.  Relationship between position of peak retinal nerve fiber layer thickness and retinal arteries on sectoral retinal nerve fiber layer thickness. , 2013, Investigative Ophthalmology and Visual Science.

[2]  Hans C Fledelius,et al.  Optic disc appearance and retinal temporal vessel arcade geometry in high myopia, as based on follow‐up data over 38 years , 2010, Acta ophthalmologica.

[3]  Stephen Doro,et al.  Conformal geometry of the retinal nerve fiber layer , 2008, Proceedings of the National Academy of Sciences.

[4]  J. Paetzold,et al.  A mathematical description of nerve fiber bundle trajectories and their variability in the human retina , 2009, Vision Research.

[5]  Martin Friedlander,et al.  Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina , 2006, Progress in Retinal and Eye Research.

[6]  Jonathan Denniss,et al.  Structure-function mapping: variability and conviction in tracing retinal nerve fiber bundles and comparison to a computational model. , 2014, Investigative ophthalmology & visual science.

[7]  B. Carlson Development of the Peripheral Nervous System , 2014 .

[8]  Michael Pircher,et al.  Retinal nerve fiber bundle tracing and analysis in human eye by polarization sensitive OCT. , 2015, Biomedical optics express.

[9]  Jonathan Denniss,et al.  An anatomically customizable computational model relating the visual field to the optic nerve head in individual eyes. , 2012, Investigative ophthalmology & visual science.

[10]  P. Carmeliet,et al.  Common mechanisms of nerve and blood vessel wiring , 2005, Nature.

[11]  B. Brela,et al.  Position of retinal blood vessels correlates with retinal nerve fibre layer thickness profiles as measured with GDx VCC and ECC , 2010, British Journal of Ophthalmology.

[12]  C. Vass,et al.  Correlation between retinal vessel density profile and circumpapillary RNFL thickness measured with Fourier-domain optical coherence tomography , 2014, British Journal of Ophthalmology.

[13]  J. Provis Development of the Primate Retinal Vasculature , 2001, Progress in Retinal and Eye Research.

[14]  K. Alitalo,et al.  Neural guidance molecules regulate vascular remodeling and vessel navigation. , 2005, Genes & development.

[15]  Makoto Nakamura,et al.  Regional relationship between retinal nerve fiber layer thickness and corresponding visual field sensitivity in glaucomatous eyes. , 2008, Archives of ophthalmology.

[16]  Gabriëlle H S Buitendijk,et al.  Population-based evaluation of retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer as a diagnostic tool for glaucoma. , 2014, Investigative ophthalmology & visual science.

[17]  Richard A. Russell,et al.  The influence of intersubject variability in ocular anatomical variables on the mapping of retinal locations to the retinal nerve fiber layer and optic nerve head. , 2013, Investigative ophthalmology & visual science.

[18]  Nomdo M. Jansonius,et al.  A mathematical model for describing the retinal nerve fiber bundle trajectories in the human eye: average course, variability, and influence of refraction, optic disc size and optic disc position. , 2012, Experimental eye research.

[19]  Paolo Fogagnolo,et al.  Mapping standard automated perimetry to the peripapillary retinal nerve fiber layer in glaucoma. , 2008, Investigative ophthalmology & visual science.

[20]  D. Garway-Heath,et al.  Mapping the visual field to the optic disc in normal tension glaucoma eyes. , 2000, Ophthalmology.

[21]  Francisco Javier Carreras,et al.  Virtual tissue engineering and optic pathways: plotting the course of the axons in the retinal nerve fiber layer. , 2014, Investigative ophthalmology & visual science.

[22]  D. Hood,et al.  Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography , 2008, Journal of glaucoma.

[23]  Andrew Turpin,et al.  Combining ganglion cell topology and data of patients with glaucoma to determine a structure-function map. , 2009, Investigative ophthalmology & visual science.